Fine structure of the ventral and dorsal lobes of the prostate in the young adult syrian hamster, <i>Mesocricetus auratus</i>

Toma, Jean G.; Buzzell, Gerald R.

doi:10.1002/aja.1001810203

Cited by 16 publications

(10 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Whole mounts of hamster prostate glands reveal that a similar situation exists in the hamster dorsal (but not ventral) lobe (unpublished obser¬ vations). In the dorsal lobe ofthe prostate, distended tubules empty into the urethra and, although secretory in nature (Toma & Buzzell, 1988), their main role is to collect and store secretion produced in the folded tubules and to pass this secretion on to the urethra. These distinctions were not apparent in the ventral lobes ofthe hamster prostate (Toma & Buzzell, 1988).…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Architecture of the dorsal and ventral lobes of the prostate of the Syrian hamster, Mesocricetus auratus, after regrowth from short day-induced regression

Buzzell

1989

Reproduction

View full text Add to dashboard Cite

The structures of the dorsal and ventral lobes of the prostate of 4 groups of Syrian hamsters were studied by a stereological approach. Groups studied were young hamsters (kept in long-day photoperiods for 4 weeks) in their first breeding season, older hamsters (kept in short-day photoperiods for 24 weeks so that their prostates had regressed and regrown) in their second breeding season, and two groups of older hamsters in an extended first breeding season (either because they were kept in long days for 24 weeks or because they were pinealectomized before being put into short-day photoperiods for 24 weeks). There were very few differences between groups, but generally dorsal prostates of older hamsters in their second breeding season closely resembled those of young hamsters in their first breeding season. More differences were noted between either of these two groups and older hamsters in an extended first breeding season than between these two groups. The differences noted generally involved increases in the amount of smooth muscle in the walls of secretory tubules in the dorsal prostates of hamsters in an extended first breeding season. This may be associated with the fact that these glands had not regressed and regrown. Ventral prostates were very similar in all 4 groups, which may reflect the fact that they normally regress very little in short days.

show abstract

Section: Discussionmentioning

confidence: 99%

“…Distended tubules were judged to have no mucosal folds which projected more than halfway to the centre of the tubule. This degree of folding and distension was not apparent in the ventral lobe (Toma & Buzzell, 1988), and so, in this gland, all tubules were treated alike. The tracings were then measured on a digitizing pad.…”

Section: Methodsmentioning

confidence: 98%

Architecture of the dorsal and ventral lobes of the prostate of the Syrian hamster, Mesocricetus auratus, after regrowth from short day-induced regression

Buzzell

1989

Reproduction

View full text Add to dashboard Cite

show abstract

“…Finasteride is used for treatment of BPH in men in a 5mg dose daily 15 . The prostate stroma of hMa is composed of loose connective tissue where the prostatic acinous are attached 10 . In men, the prostate stroma is rich in fibermuscular tissue.…”

Section: Discussionmentioning

confidence: 99%

“…The anatomic relations in prostate of hMa are well understood 10 ( Figures 1-3), turning possible the study of medication that affect this gland.…”

Section: Introductionmentioning

confidence: 99%

Effect of finasteride on serum prostate-specific antigen (PSA) and on prostate of hamster Mesocricetus auratus (hMa)

et al. 2010

View full text Add to dashboard Cite

Effect of finasteride on serum prostate-specific antigen (PSA) and on prostate of hamster Mesocricetus auratus (hMa) ABSTRACT Purpose: Evaluate the effects of finasteride on the serum PSA and on the prostate of hamster-Mesocricetus auratus(hMa). Methods: Twenty hMa male adults were split in groups control and experimental (n=10). Animals of the experimental group received 7.14ng/mL of finasteride, subcutaneously (SC) on the back three times per week, during 90 days. The finasteride dose was equivalent to 5.0mg administered to a 70kg man. At the end of the experiment the mean age for the animals in the control group was 15.2±1.13months and for the experimental group was 17.7±0.67 months. There was a statistically significant difference between mean ages of both groups (t value=5.98; p=0.001). The animals of the control group weighted 129.0±18.8g and the experimental group weighted 145.0±15.5g, t=1.88 e p=0.0514. The serum PSA was assessed through ELISA method. Prostates of those animals were collected and processed to histology and morphometry: the diameter of the acinous glands and the acinous epithelium, apoptosis, AgNORs and cellularity were assessed in both groups. Results: Serum PSA decreased in the experimental group, 0.003ng/mL versus 0.763ng/mL, H= 7.982 e p= 0.0047. Decrease in the acinous area occurred in animals that received finasteride, 238.000±24.600 µm 2 versus 398.600±55.320 µm 2 ; t= 2.653; p= 0.0122. A remarkable decrease in the area of the acinous epithelium occurred in the animals that received finasteride, 111.900±12.820 µm 2 versus 160.400±18.430 µm 2 t= 2.162; p= 0.0361. AgNORs were less expressed in finasteride treated animals, 2.846±0.877 versus 3.68 ±1.07 argyrophilic clusters for µm 2 , p= < 0.0001. Apoptosis was more intense in the experimental group, 53.62±1.389 than in controls, 14.76 ± 2.137, p= 0.0408. However, there was no statistical difference in the cellularity between both groups, 74.75±5.5 cells, in controls versus 65.07±13.24, in treated animals, p=0.5105. Conclusions: Use of finasteride decreased serum PSA and several histological parameters of the Hamster's prostate, such as lumen area, acinous and epithelium area, and AgNORs expression. Finasteride increased apoptosis in the prostate acinous cells although no significant difference in the cellularity could be found between the two groups of animals under study.

show abstract

“…The anatomy, histology and physiology of the prostate of the hamster -Mesocricetus auratus (HMA) -were described by Toma et al 5 , allowing the realization of experiments with these animals with medications that can act in this gland.…”

mentioning

confidence: 99%

O impacto na expressão agnors e apoptose na próstata do hamster-mesocricetus auratus (HMA) submetido à aplicação de finasterida

Vidigal¹,

Silva²,

Vidigal³

2011

Rev. Col. Bras. Cir.

View full text Add to dashboard Cite

ABSTRACT ABSTRACT ABSTRACTObjective Objective Objective Objective Objective: To evaluate the impact on the AgNORs expression and apoptosis in the prostate of the hamster-Mesocricetus auratus (HMA) submitted to the application of finasteride. Methods Methods Methods Methods Methods: Twenty male rodents of the species HMA (n = 20) were randomly assigned to groups of ten animals: Finasteride group (n = 10) and the Control group (n = 10). In the finasteride group 7.14 ng / mL finasteride was subcutaneously (SC) administered on the back of the animals three times a week for 90 days. AgNOR expression was evaluated as a marker of cell proliferation and apoptosis as a marker of cell death. Results Results ResultsResults Results: The expression of AgNORs was lower in the finasteride group, 2.846 ± 0.877 vs. 3.68 ± 1.07 argyrophilic regions per square micrometer (µm2) in the control group, p = <0.0001. Apoptosis was more frequent in the finasteride group, 53.62 ± 1.389 versus 14.76 ± 2.13 per µm2 in the control group, p = 0. . Investigations in animals with markers of proliferation and cell death may be of interest to corroborate these results.The anatomy, histology and physiology of the prostate of the hamster -Mesocricetus auratus (HMA) -were described by Toma et al. 5, allowing the realization of experiments with these animals with medications that can act in this gland.Vidigal et al. 6 studied the prostates of the HMA, when they had the opportunity to know the anatomy and histology of this gland. Combining theory with practice, they realized that these rodents were suitable for the development of research as experimental animals.The objective of this study therefore is to assess the impact on AgNOR expression (Argyrophilic Nuclear Organizer Regions), a marker of cell proliferation, apoptosis and cell death in the prostate of HMA submitted to finasteride treatment. We studied 20 adult HMA rodents randomly selected from those available in a vivarium, aged one year, divided into two groups: finasteride group, consisting of ten animals (n = 10); and control group, also formed by ten animals (n = 10). METHODS METHODS METHODS METHODS METHODS Experimental designThe hamsters were purchased from the animal house of the Institute of Biological Sciences, Federal University of Minas Gerais (ICB-UFMG), Belo Horizonte, Minas Gerais, Brazil. The finasteride group weighed 145 ± 15.27 g, and control group 129 ± 18.82 g.The animals were housed in plastic cages measuring 40cmx60cmx20cm (two animals per unit) and lined with wood shavings. They were fed ad libitum with chow prepared for hamsters and sunflower seeds, peanuts Vidigal Vidigal Vidigal Vidigal Vidigal The impact in the agnors expression and apoptosis in the prostate of hamster-mesocricetus auratus (HMA) submitted to finasteride application 335 Rev. Col. Bras. Cir. 2011; 38(5): 334-337 and corn. Water was offered to the animals in suction fountains. They were exposed to indirect light from 6 am to 18h and darkness for twelve hours at a temperature of 21° C.The...

show abstract

Fine structure of the ventral and dorsal lobes of the prostate in the young adult syrian hamster, Mesocricetus auratus

Cited by 16 publications

References 20 publications

Architecture of the dorsal and ventral lobes of the prostate of the Syrian hamster, Mesocricetus auratus, after regrowth from short day-induced regression

Architecture of the dorsal and ventral lobes of the prostate of the Syrian hamster, Mesocricetus auratus, after regrowth from short day-induced regression

Effect of finasteride on serum prostate-specific antigen (PSA) and on prostate of hamster Mesocricetus auratus (hMa)

O impacto na expressão agnors e apoptose na próstata do hamster-mesocricetus auratus (HMA) submetido à aplicação de finasterida

Contact Info

Product

Resources

About