Fine structure of taste buds of rabbit foliate papillae

Murray, Raymond G.; Murray, Assia

doi:10.1016/s0022-5320(67)80224-7

Cited by 118 publications

(65 citation statements)

References 25 publications

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“…2D, arrow). The microvilli of the supporting (type I) cells appear to take up a position intermediate between those of the type II and type III cells [44]. The actin-bundling proteins villin and fimbrin/plastin have been detected in the microvilli of supporting (type I) and sensory (type II) cells in taste buds [46].…”

Section: Espins In the Microvillar Processes Of Other Sensory Cellsmentioning

confidence: 99%

“…Tastant molecules bind to G protein-coupled receptors in the plasma membrane overlying their relatively short, thick microvilli, which project into the lower half of the taste pit. The PABs of type II cell microvilli often extend rootlets deep into the taste cells [44] (fig. 2D, arrowheads).…”

Section: Espins In the Microvillar Processes Of Other Sensory Cellsmentioning

confidence: 99%

“…2D, arrowheads). Type III cells appear to represent a relatively minor population of taste bud cells and are believed to display a single blunt apical microvillus that projects far up into the taste pore [41,44,45] (fig. 2D, arrow).…”

Section: Espins In the Microvillar Processes Of Other Sensory Cellsmentioning

confidence: 99%

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Espins and the actin cytoskeleton of hair cell stereocilia and sensory cell microvilli

Sekerková

Zheng

Loomis

et al. 2006

Cell. Mol. Life Sci.

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The espins are novel actin-bundling proteins that are produced in multiple isoforms from a single gene. They are present at high concentration in the parallel actin bundle of hair cell stereocilia and are the target of deafness mutations in mice and humans. Espins are also enriched in the microvilli of taste receptor cells, solitary chemoreceptor cells, vomeronasal sensory neurons and Merkel cells, suggesting that espins play important roles in the microvillar projections of vertebrate sensory cells. Espins are potent actin-bundling proteins that are not inhibited by Ca 2+ . In cells, they efficiently elongate parallel actin bundles and, thereby, help determine the steady-state length of microvilli and stereocilia. Espins bind actin monomer via their WH2 domain and can assemble actin bundles in cells. Certain espin isoforms can also bind phosphatidylinositol 4,5-bisphosphate, profilins or SH3 proteins. These biological activities distinguish espins from other actin-bundling proteins and may make them well-suited to sensory cells. KeywordsEspin; actin; hair cell; stereocilia; microvilli; sensory; deafness; taste The stereocilia and microvilli of vertebrate sensory cells and their actinbundling proteinsMany classes of vertebrate sensory cells detect chemical or mechanical stimuli through microvilli or their derivatives, such as stereocilia. These relatively long-lived, fingerlike specializations of the plasma membrane are built around a common cytoskeletal element -the parallel actin bundle (PAB) [1]. PABs consist of tightly packed collections of actin filaments cross-linked by actin-bundling proteins. The filaments are aligned along their longitudinal axis and display a uniform polarity with respect to their preferred ends for actin monomer addition, which in microvilli and stereocilia is positioned at the distal tip. The PAB displays hallmarks of a supramolecular scaffold that determines the placement, dimensions, flexibility and signaling properties of microvilli and stereocilia. Although filopodia also contain a PAB at their core and are believed to sense the local environment, they are considerably more dynamic and differ significantly from microvilli and stereocilia in their molecular composition and biogenesis [2].

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Section: Espins In the Microvillar Processes Of Other Sensory Cellsmentioning

confidence: 99%

Section: Espins In the Microvillar Processes Of Other Sensory Cellsmentioning

confidence: 99%

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Espins and the actin cytoskeleton of hair cell stereocilia and sensory cell microvilli

Sekerková

Zheng

Loomis

et al. 2006

Cell. Mol. Life Sci.

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“…Previous papers on the fine structure of taste buds demonstrated the occurrence of tight junctions and desmosomes in them (DE LORENZO, 1958;SCALZI, 1966;MURRAY andMURRAY, 1967, 1970;MILLER and CHAUDHRY, 1976). But the existence and distribution of gap junctions in the buds have not been clarified yet.…”

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confidence: 99%

Taste Buds in the Vallate Papillae of the Rat Studied with Freeze-Fracture Preparation

Akisaka

Oda

1978

Arch. Histol. Jap., Arch. Histol. Jpn

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“…The ultrastructure of taste bud has been studied and thoroughly described in a number of amphibian and avian species (Farbman and Yonkers 1971;and others), in laboratory mammals (Farbman 1965a;Murray et al 1969Murray et al , 1972Fujimoto and Murray 1970;Takeda and Hoshino 1975;Takeda 1976;and others) and also in man (Takeda 1972;Paran et aI. 1975;etc.…”

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confidence: 99%

The Ultrastructure of Taste Buds in the Newborn Pig

Tichý¹

1992

Acta Vet. Brno

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Tichy, F.: The Ultrastructure of Taste Buds in the Newborn Pig. ACta 'vet. Brno, 61,1992: 171-177. . . Taste buds localized on circumvallate papillae of the porcine tongue were investigated for the occurrence of dark, light and receptor cells and the stage of their differentiation, the morphology of the taste pore area, the occurrence and distrioution of intragemmal nerve endings and the way in which these are connected with each cell type.It was observed that, as early as two days after birth, the porcine taste buds included all three cell types. These were elongated towards the taste pore. Their apical parts, however, did not come up to level with the epithelial surface nor were they shaped into microvilli typical of the bud ultrastructure described in adult animals of other mammalian species. The cytoplasm of the dark cells had only a low amount of dark secretory granules and the receptor cells showed only occasional occurrence of dark vesicles. The dark, light and receptor cells were connected with nerve fibres and the way of contact was different in each cell type.Taste bud, taste pore, gustatory nerve. ultrastructureThe ultrastructure of taste bud has been studied and thoroughly described in a number of amphibian and avian species (Farbman and Yonkers 1971; and others), in laboratory mammals (Farbman 1965a;Murray et al. 1969Murray et al. , 1972Fujimoto and Murray 1970;Takeda and Hoshino 1975;Takeda 1976; and others) and also in man (Takeda 1972; Paran et aI. 1975; etc.) The results of ultrsstructura1 studies of taste buds have revealed considerable differences which are species-specific and also related to the position of the bud in the lingual mucosa (B e i dler

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Fine structure of taste buds of rabbit foliate papillae

Cited by 118 publications

References 25 publications

Espins and the actin cytoskeleton of hair cell stereocilia and sensory cell microvilli

Espins and the actin cytoskeleton of hair cell stereocilia and sensory cell microvilli

Taste Buds in the Vallate Papillae of the Rat Studied with Freeze-Fracture Preparation

The Ultrastructure of Taste Buds in the Newborn Pig

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