Fine Structure of Lymphogranuloma Venereum Agent and the Effects of Penicillin and 5-Fluorouracil

Interaction of L Cells andChlamydia psittaci: Entry of the Parasite and Host Responses to Its Development

“…The integrity of the C. psittaci-containing phagocytic vacuole is evident from the observations made in this study. The postulated sequence of morphological forms, from the infectious elementary body to the vegetative reticulate body and back to the elementary body, is completely consistent with previous observations made by Bedson and Bland (7), Litwin (27), Higashi (22), and Armstrong and Reed (6). Early difficulties with the resolution of the limiting membrane of the phagocytic vacuole and the wall structure of the chlamydiae were not a problem in this study.…”

Ultrastructural Analysis of the Effects of Penicillin and Chlortetracycline on the Development of a Genital Tract Chlamydia

“…VOL. 3,1971 339 on August 31, 2020 by guest http://iai.asm.org/ Downloaded from KRAMER AND GORDON bodies and stained blue, whereas the elementary bodies that were present in the control cells stained red.…”

“…For this study, strain MRC-1/G of C. trachomatis was chosen as a well-known genital tract isolate (13) to compare with the previously examined strains of different origins. The comparison included the effect of penicillin, which has been described for other isolates (3,14,19,(20)(21)(22). Chlortetracycline is used in the treatment of nongonococcal urethritis, and its effect on the developmental cycle of isolate MRC-1/G was investigated in detail in this study by electron microscopy.…”

Persistent chlamydiae: from cell culture to a paradigm for chlamydial pathogenesis.

“…The exact nature of host-supplied factors and the environmental conditions for typical chlamydial development are unknown. However, deviations from the typical developmental cycle correspond significantly to a variety of alterations in growth conditions, including the presence of antibiotics (3,21,49,59,67,78,119) or host-elaborated factors (10, 66, 107) and deviations in the levels of essential nutrients (1, 25). These conditions generally delay RB maturation, inhibit differentiation to infectious EBs, and are associated with gross morphological alterations of RBs typified by markedly enlarged, atypical chlamydial forms.…”