Fine structure of artificial splits in femoral condylar cartilage of the rat: A scanning electron microscopic study

OʼConnor, Patricia; Bland, Christine; Gardner, D. L.

doi:10.1002/path.1711320207

Cited by 8 publications

(1 citation statement)

References 12 publications

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“…5b) was aligned perpendicular to the cartilage surface along the z ‐direction (the direction of the surface normal axis). The transverse y ‐bundle is highly consistent with the results in one of our previous studies (23), which represents the nonrandom distribution of the horizontal fibrils in the SZ cartilage and relates in some way to the split‐line appearance of the cartilage surface (1, 3, 27–32). The identification of the vertical z ‐bundle in the SZ cartilage, which was the strongest near the cartilage surface (the smallest ratio in Fig.…”

Section: Discussionsupporting

confidence: 89%

Good outcome and valve function despite medtronic‐corevalve underexpansion

Jilaihawi

Asgar

Bonan

2010

Cathet Cardio Intervent

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An 80-year old nun with severe calcific aortic stenosis and a bicuspid aortic valve was referred for transcatheter aortic valve implantation. She was declined for conventional surgery on the basis of poor left ventricular function, frailty, and a logistic EuroSCORE of 29.66. A 29-mm Medtronic-Corevalve bioprosthesis was implanted by transfemoral route. The inflow portion of the stent frame was grossly underexpanded. However, aortic valve area at 1.3 cm(2) was more than satisfactory for a body surface area of 1.29 m(2) (indexed area 1.0 cm(2)/m(2), peak gradient 23, and mean 16 mmHg). There was an early sustained improvement in New York Heart Association (NYHA) status, and there was no change in valvular function at 2 year follow-up. This case highlights that gross underexpansion of the Medtronic-Corevalve stent frame is compatible with good bioprosthetic function and excellent symptomatic recovery.

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Section: Discussionsupporting

confidence: 89%

Good outcome and valve function despite medtronic‐corevalve underexpansion

Jilaihawi

Asgar

Bonan

2010

Cathet Cardio Intervent

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Further studies on the anisotropic distribution of collagen in articular cartilage by μMRI

Zheng¹,

Xia²,

Badar³

2010

Magnetic Resonance in Med

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To further study the anisotropic distribution of the collagen matrix in articular cartilage, microscopic magnetic resonance imaging experiments were carried out on articular cartilages from the central load-bearing area of three canine humeral heads at 13 mm resolution across the depth of tissue. Quantitative T 2 images were acquired when the tissue blocks were rotated, relative to B 0 , along two orthogonal directions, both perpendicular to the normal axis of the articular surface. The T 2 relaxation rate (R 2 ) was modeled, by three fibril structural configurations (solid cone, funnel, and fan), to represent the anisotropy of the collagen fibrils in cartilage from the articular surface to the cartilage/bone interface. A set of complex and depth-dependent characteristics of collagen distribution was found in articular cartilage. In particular, there were two anisotropic components in the superficial zone and an asymmetrical component in the radial zone of cartilage. A complex model of the three-dimensional fibril architecture in articular cartilage is proposed, which has a leaf-like or layer-like structure in the radial zone, arises in a radial manner from the subchondral bone, spreads and arches passing the isotropic transitional zone, and exhibits two distinct anisotropic components (vertical and transverse) Structural architecture of articular cartilage plays a critical role in the biomechanical functions and morphological properties of the tissue as a load-bearing material in joints (1-6), whose degradation is the hallmark of clinical joint diseases such as osteoarthritis. As the collagen fibril is the principal macromolecule that provides a depth-dependent structural integrity to articular cartilage (7), continuing efforts have been focused on the specific features of the three-dimensional (3D) collagen structure in cartilage. Histologically, the collagen matrix in noncalcified cartilage is commonly considered to contain three structural zones from the articular surface to the cartilage bone interface, namely, the superficial zone (SZ) with the collagen fibrils parallel with the tissue surface, the transitional zone (TZ) with mostly random fibrils, and the radial zone (RZ) with the perpendicular fibrils anchored to the underlining bone. These depth-dependent features of the collagen matrix become the fundamental components in several fibril models in literature, including the arcade model (8), where the collagen fibrils arise in a radial manner from the subchondral bone, pass toward the surface through the TZ obliquely, and return to the bone; the columnar arrangement (9,10), where the collagens are arranged in a columnar manner, that could be traced from the calcified cartilage to their oblique orientation in the tangential tissue matching the concept of the arcade model; and the leaf model (3,5,10,11), where the collagens are arranged in a series of closely packed layers or leaves in the RZ and arches in the TZ to form the horizontally orientated leaves in the SZ.The structural orientation of collagen ...

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Orientation Mechanisms of Collagen

Ito¹,

Tepic²

1997

Hefte Zur Zeitschrift „Der Unfallchirurg“

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Fine structure of artificial splits in femoral condylar cartilage of the rat: A scanning electron microscopic study

Cited by 8 publications

References 12 publications

Good outcome and valve function despite medtronic‐corevalve underexpansion

Good outcome and valve function despite medtronic‐corevalve underexpansion

Further studies on the anisotropic distribution of collagen in articular cartilage by μMRI

Orientation Mechanisms of Collagen

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