Fine Structure and Cytochemistry of the Mammalian Pars Intermedia

Stoeckel, M. E.; Schmitt, Gisela; Porte, A

doi:10.1002/9780470720646.ch7

Cited by 28 publications

(2 citation statements)

References 45 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Some authors suggest that these cells belong to the folliculostellate cells for which the S100 protein is the best marker (Cocchia and Miani 1980;Nakajima et al 1980;Allaerts and Vankelecom 2005). GFAP-immunopositive stellate cells have also been mentioned in this area (Stoeckel et al 1981;. Berardi et al (1999) even found laminin immunoreactivity covering the melanotrope cells of the intermediate lobe.…”

Section: Glial Markers In the Neurohypophysismentioning

confidence: 99%

Components of the Basal Lamina and Dystrophin–Dystroglycan Complex in the Neurointermediate Lobe of Rat Pituitary Gland: Different Localizations of β-Dystroglycan, Dystrobrevins, α1-Syntrophin, and Aquaporin-4

Pócsai

Bagyura

Kálmán

2010

J Histochem Cytochem.

View full text Add to dashboard Cite

The so-called neurointermediate lobe is composed of the intermediate and neural lobes of the pituitary. The present immunohistochemical study investigated components of the basal lamina (laminin, agrin, and perlecan), the dystrophin-dystroglycan complex (dystrophin, beta-dystroglycan, alpha1-dystrobrevin, beta-dystrobrevin, utrophin, and alpha1-syntrophin), and the aquaporins (aquaporin-4 and -9). Glia markers (GFAP, S100, and glutamine synthetase) and components of connective tissue (collagen type I and fibronectin) were also labeled. In the neurohypophysis, immunostaining of basal lamina delineated meningeal invaginations. In these invaginations, vessels were seen to penetrate the organ without submerging into its parenchyma. On the parenchymal side of the invaginations, beta-dystroglycan was detected, whereas utrophin was detected in the walls of vessels. Immunostaining of alpha1-dystrobrevin and alpha1-syntrophin did not delineate the vessels. The cells of the intermediate lobe were fully immunoreactive to alpha1-dystrobrevin and alpha1-syntrophin, whereas components of the basal lamina delineated the contours of the cells. GFAP-immunoreactive processes surrounded them. Aquaporin-4 localized at the periphery of the neurohypophysis, mainly adjacent to the intermediate lobe but not along the vessels. It colocalized only partially with GFAP and not at all with alpha1-syntrophin. Aquaporin-9 was not detected. These results emphasize the possibility that the components of the dystrophin-dystroglycan complex localize differently and raise the question about the roles of dystrobrevins, alpha1-syntrophin, and aquaporin-4 in the functions of the intermediate and neural lobes, respectively.

show abstract

Section: Glial Markers In the Neurohypophysismentioning

confidence: 99%

Components of the Basal Lamina and Dystrophin–Dystroglycan Complex in the Neurointermediate Lobe of Rat Pituitary Gland: Different Localizations of β-Dystroglycan, Dystrobrevins, α1-Syntrophin, and Aquaporin-4

Pócsai

Bagyura

Kálmán

2010

J Histochem Cytochem.

View full text Add to dashboard Cite

show abstract

“…The pars intermedia of the frog pituitary presents several particular features that make it a very suitable model for investigating the process of neuroendocrine communication. In contrast to the intermediate lobe of mammals, which generally contains a certain proportion of corticotrope cells, 15,16 the frog pars intermedia is composed only of melanotrope cells. 17 Although two subpopulations of endocrine cells with distinct biochemical and functional characteristics coexist in the pars intermedia of the European green frog Rana ridibunda , 18,19 all endocrine cells of the intermediate lobe belong to the melanotrope phenotype.…”

Section: The Intermediate Lobe Of the Frog Pituitary As A Model Of Nementioning

confidence: 99%

The Pituitary‐Skin Connection in Amphibians: Reciprocal Regulation of Melanotrope Cells and Dermal Melanocytes

Vaudry

Chartrel

Desrues

et al. 1999

Annals of the New York Academy of Sciences

View full text Add to dashboard Cite

In amphibians, ␣ -MSH secreted by the pars intermedia of the pituitary plays a pivotal role in the process of skin color adaptation. Reciprocally, the skin of amphibians contains a number of regulatory peptides, some of which have been found to regulate the activity of pituitary melanotrope cells. In particular, the skin of certain species of amphibians harbours considerable amounts of thyrotropin-releasing hormone, a highly potent stimulator of ␣ -MSH release. Recently, we have isolated and sequenced from the skin of the frog Phyllomedusa bicolor -a novel peptide named skin peptide tyrosine tyrosine (SPYY), which exhibits 94% similarity with PYY from the frog Rana ridibunda. For concentrations ranging from 5 ؋ 10 -10 to 10 -7 M, SPYY induces a dose-related inhibition of ␣ -MSH secretion. At a dose of 10 -7 M, SPYY totally abolished ␣ -MSH release. These data strongly suggest the existence of a regulatory loop between the pars intermedia of the pituitary and the skin in amphibians.

show abstract

Regulation of GFAP expression in glial‐like cells of the rat pituitary intermediate lobe by lactation, salt‐loading, and adrenalectomy

Gary

Chronwall

1995

Glia

View full text Add to dashboard Cite

Glial-like cells in rat pituitary intermediate lobe were localized and characterized by immunohistochemistry with antisera against glial fibrillary acidic protein (GFAP) and S-100. Individual GFAP immunoreactive (IR) cells possessed several processes that often branched into secondary and tertiary processes, terminating with end-feet. The GFAP-immunopositive cell population was distributed in specific rostrocaudal and dorsoventral patterns. The distribution and numbers of cells differed between male and female rats. Examination of altered physiological states, e.g., adrenalectomy, lactation, and salt-loading, revealed state-specific changes in the appearance and distribution of GFAP-IR cells. Adrenalectomy and lactation increased GFAP-IR glial-like cell numbers, whereas salt-loading decreased their numbers and the typical pattern of distribution. By contrast, S-100-expressing cells were evenly distributed in male and female rats, and its expression was not affected by the experimental conditions. Double-label immunocytochemistry indicated that GFAP-IR cells are a subpopulation of S-100-IR cells. These results suggest that cells normally expressing only S-100 may be induced to express GFAP under altered physiologic conditions.

show abstract

Fine Structure and Cytochemistry of the Mammalian Pars Intermedia

Cited by 28 publications

References 45 publications

Components of the Basal Lamina and Dystrophin–Dystroglycan Complex in the Neurointermediate Lobe of Rat Pituitary Gland: Different Localizations of β-Dystroglycan, Dystrobrevins, α1-Syntrophin, and Aquaporin-4

Components of the Basal Lamina and Dystrophin–Dystroglycan Complex in the Neurointermediate Lobe of Rat Pituitary Gland: Different Localizations of β-Dystroglycan, Dystrobrevins, α1-Syntrophin, and Aquaporin-4

The Pituitary‐Skin Connection in Amphibians: Reciprocal Regulation of Melanotrope Cells and Dermal Melanocytes

Regulation of GFAP expression in glial‐like cells of the rat pituitary intermediate lobe by lactation, salt‐loading, and adrenalectomy

Contact Info

Product

Resources

About