Fine particulate matter (PM2.5) inhibits ciliogenesis by increasing SPRR3 expression via c-Jun activation in RPE cells and skin keratinocytes

Bae, Ji-Eun; Choi, Hyunjung; Shin, Dong Woon; Park, Na Yeon; Kim, Joon Bum; Jo, Doo Sin; Cho, Min Ji; Lyu, Jung Ho; Chang, Jeong Ho; Lee, Eunjoo H.; Lee, Tae Ryong; Kim, Hyoung-June; Cho, Dong‐Hyung

doi:10.1038/s41598-019-40670-y

Cited by 23 publications

(22 citation statements)

References 52 publications

(50 reference statements)

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“…SPRR3 was shown to be upregulated in keratinocytes treated with PM 2.5 [132]. SPRR3 upregulation has been shown to decrease ciliogenesis in vitro [140], which is responsible for suppressing skin pigmentation in melanocytes [151].…”

Section: Physical Barriermentioning

confidence: 97%

“…Additionally, markers for proliferation, such as Ki67, 5-bromo-2′-deoxyuridine (BrdU) incorporation, and proliferating cell nuclear antigen (PCNA), were shown to be decreased upon PM exposure [125,130]. Reduced expression of differentiation and proliferation markers was also shown in 2D models, i.e., HaCaT and NHEK cells [122,125,127,140,141,143,144].…”

Section: Physical Barriermentioning

confidence: 98%

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Impact of airborne particulate matter on skin: a systematic review from epidemiology to in vitro studies

Dijkhoff¹,

Drašler²,

Karakoçak³

et al. 2020

Part Fibre Toxicol

115

116

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Background: Air pollution is killing close to 5 million people a year, and harming billions more. Air pollution levels remain extremely high in many parts of the world, and air pollution-associated premature deaths have been reported for urbanized areas, particularly linked to the presence of airborne nano-sized and ultrafine particles. Main text: To date, most of the research studies did focus on the adverse effects of air pollution on the human cardiovascular and respiratory systems. Although the skin is in direct contact with air pollutants, their damaging effects on the skin are still under investigation. Epidemiological data suggested a correlation between exposure to air pollutants and aggravation of symptoms of chronic immunological skin diseases. In this study, a systematic literature review was conducted to understand the current knowledge on the effects of airborne particulate matter on human skin. It aims at providing a deeper understanding of the interactions between air pollutants and skin to further assess their potential risks for human health. Conclusion: Particulate matter was shown to induce a skin barrier dysfunction and provoke the formation of reactive oxygen species through direct and indirect mechanisms, leading to oxidative stress and induced activation of the inflammatory cascade in human skin. Moreover, a positive correlation was reported between extrinsic aging and atopic eczema relative risk with increasing particulate matter exposure.

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Section: Physical Barriermentioning

confidence: 97%

Section: Physical Barriermentioning

confidence: 98%

Impact of airborne particulate matter on skin: a systematic review from epidemiology to in vitro studies

Dijkhoff¹,

Drašler²,

Karakoçak³

et al. 2020

Part Fibre Toxicol

115

116

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show abstract

“…Skin is the largest organ of the human body, as well as the primary organ which is exposed to outdoor contaminants. Exposure to PM causes epithelium damage, and endothelial dysfunction has been reported previously [8,9,38]. PM induce skin damages or diseases mainly through stimulating inflammatory response and oxidative stress [5,39].…”

Section: Discussionmentioning

confidence: 78%

Protective Effect of Diphlorethohydroxycarmalol Isolated from Ishige okamurae Against Particulate Matter-Induced Skin Damage by Regulation of NF-κB, AP-1, and MAPKs Signaling Pathways In Vitro in Human Dermal Fibroblasts

Wang

Kim

et al. 2020

Molecules

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Particulate matters (PM), the main contributor to air pollution, have become a serious issue that threatens human’s health. Skin is the largest organ in humans, as well as the primary organ exposed to PM. Overexposure of PM induces skin damage. Diphlorethohydroxycarmalol (DPHC), an algal polyphenol with the potential of skin protection, has been isolated from the edible brown seaweed Ishige okamurae. The purpose of the present study is to investigate the protective effect of DPHC against PM (ERM-CZ100)-induced skin damage in human dermal fibroblasts (HDF) cells. The results indicated that DPHC significantly and dose-dependently reduced intracellular reactive oxygen species generation in HDF cells. In addition, DPHC significantly induced collagen synthesis and inhibited collagenase activity in ERM-CZ100-stimulated HDF cells. Further study demonstrated that DPHC remarkably reduced the expression of human matrix metalloproteinases through regulation of nuclear factor kappa B, activator protein 1, and mitogen-activated protein kinases signaling pathways in ERM-CZ100-stimulated HDF cells. This study suggested that DPHC is a potential candidate to protect skins against PM-induced damage, and it could be used as an ingredient in pharmaceutical and cosmeceutical industries.

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“…However, the mechanisms of how PM induces and aggravates eczema in humans have not yet been elucidated. It is likely that PM induces the disruption of the epidermis by modulating the structural proteins including small proline-rich (SPRR) family, occludens-1 (ZO-1), keratins, laggrin, and claudin-1 [39][40][41][42][43][44][45] , thereby resulting in both increased epithelial and endothelial barrier permeability 46 .Moreover, a previous study reported that the penetration of PM was observed in both intact and barrier-disrupted skin in vivo, resulting in in ammatory responses 47 . Current scienti c opinions on the down-stream mechanisms through which air pollutants affect skin health mainly include: 1) elevation of oxidative stress via exogenous and endogenous reactive oxygen species (ROS) generation, which is a series of a highly reactive chemical substances.…”

Section: Discussionmentioning

confidence: 99%

Short-term Exposure of PM2.5 and PM10 Increases the Number of Outpatients with Eczema in Guangzhou: A Time-Series Study

Ji¹,

Yang²,

Xu³

et al. 2020

Preprint

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Background: The worldwide prevalence of eczema has continued to rise over the past decades.This has led to emphasis on the association between air pollution and eczema. This study investigated the relationship between daily exposure to air pollution and the number of eczema outpatient visits in Guangzhou with the overarching goal of providing novel insights on the interventions for eczema aggravation and prevention.Methods: Daily air pollution data, meteorological data, and number of eczema outpatients were obtained from 18th January 2013 to 31st December 2018 in Guangzhou. A generalized additive model with Poisson distribution was used to assess the association between the number of eczema outpatient visits and short-term exposure of PM2.5 and PM10. In addition, the effect of PM2.5 and PM10 by age (<65 years, ≥65 years) and gender was evaluated. Results: A total of 293,343 eczema outpatient visits were recorded. The obtained results indicated that a 10μg/m3 increase of the same day/ lag 1 day/ lag 2 days PM2.5 was associated with increments of 2.33%(RR=1.0233, 95%CI: 1.0206-1.0260, P<0.001), 1.81% (RR=1.0181, 95%CI: 1.0153-1.0209, P<0.001), and 0.95%(RR=1.0095, 95%CI: 1.0068-1.0123, P<0.001) in eczema outpatients risk, respectively. On the other hand, a 10μg/m3 increase of PM10 was associated with eczema outpatients risk increments of 1.97%(RR=1.0197, 95%CI: 1.0177-1.0217, P<0.001), 1.65%(RR=1.0165, 95%CI: 1.0145-1.0186, P<0.001), and 0.98%(RR=1.0098, 95%CI: 1.0078-1.0118, P<0.001), respectively. Furthermore, the effects of PM on the increment of eczema were similar in the male and female groups. Results obtained after age stratification analyses indicated that the strongest positive association between PM2.5 exposure and eczema were observed at lag 0 day with the percent changes being 4.72% (95%CI, 4.18-5.28%, P<0.001), 1.92%(95%CI: 1.65-2.19%, P<0.001) and 3.34% (95%CI, 2.9- 3.78%, P<0.001) in <12 years old, ≥12 and <65years old, and ≥65 years old groups, respectively. Conclusion: Short-term exposure of PM2.5 and PM10 increases the number of eczema outpatients especially among children and the elderly. This study has provided a further understanding of the relationship between air pollutants and eczema, which will benefit disease prevention and lower the health burden.

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Fine particulate matter (PM2.5) inhibits ciliogenesis by increasing SPRR3 expression via c-Jun activation in RPE cells and skin keratinocytes

Cited by 23 publications

References 52 publications

Impact of airborne particulate matter on skin: a systematic review from epidemiology to in vitro studies

Impact of airborne particulate matter on skin: a systematic review from epidemiology to in vitro studies

Protective Effect of Diphlorethohydroxycarmalol Isolated from Ishige okamurae Against Particulate Matter-Induced Skin Damage by Regulation of NF-κB, AP-1, and MAPKs Signaling Pathways In Vitro in Human Dermal Fibroblasts

Short-term Exposure of PM2.5 and PM10 Increases the Number of Outpatients with Eczema in Guangzhou: A Time-Series Study

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