Fine particulate matter air pollution and subclinical cardiovascular outcomes: A longitudinal study in 15 Chinese cities

Hu, Jialu; Li, Wenshu; Gao, Ya; Zhao, Gang; Jiang, Yu-Long; Wang, Weidong; Cao, Mengying; Zhu, Yixiang; Niu, Yue; Ge, Junbo; Chen, Renjie

doi:10.1016/j.envint.2022.107218

Cited by 20 publications

(6 citation statements)

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“…However, several limitations of the study indoor and outdoor pollution and the bias brought by the study population sample selection 39,40) . Notably, short-term exposure to PM2.5 may induce vascular stiffness in the general population in China and India 41,43) , consistent with our results from studies that included participants with metabolic disorders. In particular, we focused on the population with metabolic disorders, and previous studies suggested a higher susceptibility risk for PM2.5 exposure in these participants 44,45) , which has not been elucidated in China.…”

Section: Discussionsupporting

confidence: 89%

“…The effect of PM2.5 exposure on arterial stiffness has been controversial in the general population [38][39][40][41][42] . We found a consistent and positive association between chronic exposure and PM2.5 and its five chemical constituents, with elevated baPWV representing arterial stiffness in participants with metabolic disorders.…”

Section: Characteristics Of Air Pollutantsmentioning

confidence: 99%

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Long-Term Exposure to Fine Particulate Constituents and Vascular Damage in a Population with Metabolic Abnormality in China

Lin

Huang

Fang

et al. 2023

JAT

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Aim: To date, PM2.5-associated vascular damage in metabolic abnormalities has remained controversial. We knew little about the vascular damage of PM2.5 constituents. Thus, this study aimed to investigate the relationship between long-term exposure to PM2.5 and its constituents and vascular damage in metabolic abnormalities. Methods: A total of 124,387 participants with metabolic abnormalities (defined as at least one metabolic disorder, such as obesity, elevated blood pressure, elevated triglyceride level, elevated fasting glucose level, or low HDL cholesterol level) were recruited in this study from 11 representative centers in China between January 2011 and December 2017. PM2.5 and its constituents (black carbon [BC], organic matter [OM], sulfate [SO4 2− ], nitrate [NO3 − ], and ammonium salts [NH4 ＋ ]) were extracted. Elevated brachial-ankle pulse wave velocity (baPWV) (≥ 1,400 cm/s) and declined ankle-brachial index (ABI) (＜0.9) indicated vascular damage. Multivariable logistic regression and Quantile g-Computation models were utilized to explore the impact on outcomes.Results: Of the 124,387 participants (median age, 49 years), 87,870 (70.64%) were men. One-year lag exposure to PM2.5 and its constituents was significantly associated with vascular damage in single pollutant models. The adjusted odds ratios (OR) for each 1-μg/m 3 increase in PM2.5 was 1.013 (95% CI, 1.012-1.015) and 1.031 (95% CI, 1.025-1.037) for elevated baPWV and decreased ABI, respectively. PM2.5 constituents were also associated with vascular damage in multi-pollutant models. Among the PM2.5 constituents, BC (47.17%), SO4 2− (33.59%), and NH4 ＋ (19.23%) have the highest contribution to elevated baPWV and NO3 − (47.89%) and BC (23.50%) to declined ABI. Conclusion:Chronic exposure to PM2.5 and PM2.5 constituents was related to vascular damage in the abnormal metabolic population in China. The heterogeneous contribution of different PM2.5 constituents to vessel bed damage is worthy of attention when developing targeted strategies.

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Section: Discussionsupporting

confidence: 89%

Section: Characteristics Of Air Pollutantsmentioning

confidence: 99%

Long-Term Exposure to Fine Particulate Constituents and Vascular Damage in a Population with Metabolic Abnormality in China

Lin

Huang

Fang

et al. 2023

JAT

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“…Potential explanations for such differences may be due to self-reported smoking status extracted from questionnaires taken by participants at physical examination centers, which may underestimate the rate of smoking. The study based on multiple healthcheckup centers also showed self-reported smoking rate is 10.7%, which is lower than the rate in national survey [63]. We recognized the bias from underestimated smokers in this study.…”

Section: Discussioncontrasting

confidence: 47%

Association between one-year exposure to air pollution and the prevalence of pulmonary nodules in China

et al. 2023

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Background: PM2.5 is a well-known airborne hazard to cause various diseases. Evidence suggests that air pollution exposure contributes to the occurrence of pulmonary nodules. Pulmonary nodules detected on the CT scans can be malignant or progress to malignant during follow-up. But the evidence of the association between PM2.5 exposure and pulmonary nodules was limited. Objective: To examine potential associations of exposures to PM2.5 and its major chemical constituents with the prevalence of pulmonary nodules.Methods: 16865 participants were investigated from eight physical examination centers in China from 2014 to 2017. The daily concentrations of PM2.5 and its five components were estimated by high-resolution and high-quality spatiotemporal datasets of ground-level air pollutants in China. The logistic regression and the quantile-based g-computation models were used to assess the single and mixture impact of air pollutant PM2.5 and its components on the risk of pulmonary nodules, respectively. Results: Each 1mg/m3 increase in PM2.5 (OR 1.011 (95%CI: 1.007-1.014)) was positively associated with pulmonary nodules. Among five PM2.5 components, in single-pollutant effect models, every 1 μg/m3 increase in OM, BC, and NO3- elevated the risk of pulmonary nodule prevalence by 1.040 (95%CI: 1.025-1.055), 1.314 (95%CI: 1.209-1.407) and 1.021 (95%CI: 1.007-1.035) fold, respectively. In mixture-pollutant effect models, the joint effect of every quintile increase in PM2.5 components was 1.076 (95%CI: 1.023-1.133) fold. Notably, NO3- BC and OM contributed higher risks of pulmonary nodules than other PM2.5 components. And the NO3- particles were identified to have the highest contribution. The impacts of PM2.5 components on pulmonary nodules were consistent across gender and age.Conclusion: These findings provide important evidence for the positive correlation between exposure to PM2.5 and pulmonary nodules in China and identify that NO3- particles have the highest contribution to the risk.

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“…[177] A longitudinal study in Nanjing demonstrated that the short-term exposure to PM 2.5 elevated the fasting blood glucose. [178] It can also induce early cardiovascular effects in general population, in-cluding myocardial injury, increased blood viscosity and vascular stiffness as confirmed in a study performed in 15 cities in China. [179] Long-term exposure to fine particulate matter increases the incidence of hypertension, diabetes and overweight/obesity.…”

Section: Short-term Effect Of Ambient Air Pollution On Cvdmentioning

confidence: 81%

Cardiovascular Risk Factors in China

2024

Journal of Geriatric Cardiology

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The Annual Report on Cardiovascular Health and Diseases in China (2022) intricate landscape of cardiovascular health in China. This section dissects cardiovascular risk factors in China which including hypertension, dyslipidemia, diabetes mellitus, chronic kidney disease, metabolic syndrome and air pollution. Hypertension prevalence has steadily increased in China, with efforts to control it facing challenges in achieving optimal rates, especially in rural areas. Interventions like salt substitutes and intensive blood pressure control show promise but need improvement. Abnormal lipid levels, indicative of dyslipidemia, have risen significantly, posing a risk for cardiovascular diseases. Despite efforts, many patients struggle to achieve target lipid levels, necessitating improved treatment strategies. Both type 1 and type 2 diabetes mellitus affect millions of adults in China, with long-term complications adding to the disease burden. Early intervention and effective management are crucial to mitigate its impact. Prevalent among older adults, chronic kidney disease is associated with diabetes mellitus, hypertension, and cardiovascular diseases, necessitating comprehensive management approaches. The prevalence of metabolic syndrome, characterized by a cluster of risk factors, has increased in both adults and adolescents, calling for lifestyle modifications and public health interventions. Ambient and household air pollution remain significant environmental risk factors, despite some improvements in air quality. Continued efforts to reduce emissions are essential for mitigating associated health risks. Addressing these risk factors requires a multifaceted approach, including public health initiatives, policy interventions, and individual-level strategies to promote healthy lifestyles and reduce environmental exposures. Surveillance and research efforts are crucial for monitoring trends and developing effective strategies to lessen the burden of cardiovascular diseases in China.CARDIOVASCULAR

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Fine particulate matter air pollution and subclinical cardiovascular outcomes: A longitudinal study in 15 Chinese cities

Cited by 20 publications

References 49 publications

Long-Term Exposure to Fine Particulate Constituents and Vascular Damage in a Population with Metabolic Abnormality in China

Long-Term Exposure to Fine Particulate Constituents and Vascular Damage in a Population with Metabolic Abnormality in China

Association between one-year exposure to air pollution and the prevalence of pulmonary nodules in China

Cardiovascular Risk Factors in China

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