Fine-needle biopsy of the pancreas using real-time ultrasonography

Abstract

Percutaneous fine-needle biopsy of the pancreas by real-time ultrasonography was performed in 45 patients with suspected pancreatic carcinoma. True-positive diagnoses were obtained in 27 cases, 11 examinations yielded true-negative results, 3 results were false-negative, 2 were equivocal, and 2 samples were inadequate. The overall success rate was 84.4%. No false-positive cytologic diagnoses were made. Complications were not seen in any of the patients. The results confirm the effectiveness, safety, and relatively low cost of this procedure.

Reliability of Ultrasound-Guided Fine-Needle Biopsy of Pancreatic Masses

“…The present results, with a frequency of false negative samples of 10 per cent, and an accuracy and sensitivity around 90 per cent, correspond well with the figures obtained in other investigations concerning sonographically guided FNB (Table 3) (3,4,9,12,16,17,21,25,28,31,33,36,37). The prevalence of malignant disease in this material was high.…”

Intraoperative fine needle aspiration cytology of pancreatic lesions

“…The introduction of FNA of the pancreas directed by imaging methods permitted evaluation of the patients without laparotomy and open biopsy of the pancreas. Thus, studies [18][19][20][21][22][23] on preoperative FNA cytology under US guidance reported sensitivity from 66.7% to 100% and specificity of 100% in all series but one [21]. The sensitivity of FNA cytology under CT guidance among 318 cases published in six series [24-291 ranged from 67.2% to 83.3%, while the specificity was 100%.…”

“…Pancreatic biopsy for histologic examination is risky and may be associated with the complications such as pancreatitis, fistula, hemorrhage, and pseudocyst formation, and even death [2-51; in many instances, it still does not disclose the malignancy. Instead, fine needle aspiration (FNA) cytology of the pancreas during surgery [I , 3 , 0 1991 Wiley-Liss, Inc. [6][7][8][9][10][11][12][13][14][15][16][17] or under the guidance of imaging methods [18][19][20][21][22][23][24][25][26][27][28][29] was suggested as a safe and accurate method to differentiate malignant from benign pancreatic lesions. Based on acquired experience in ultrasound (US)-guided FNA of pancreatic masses, FNA was applied intraoperatively either as alternative to biopsy or in combination with it.…”