Fine-needle aspiration of the thyroid and correlation with histopathology in a contemporary series of 240 patients

Sclabas, Guido M.; Staerkel, Gregg; Shapiro, Suzanne E.; Fornage, Bruno D.; Sherman, Steven I.; Vassillopoulou-Sellin, Rena; Lee, Jeffrey E.; Evans, Douglas B.

doi:10.1016/j.amjsurg.2003.08.015

Cited by 245 publications

(195 citation statements)

References 22 publications

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“…These features can be seen in aspirates from Hashimoto's thyroiditis, nodular hyperplasia, follicular adenoma, and Hurthle cell adenoma. 20 The 6.1% false-negative rate for malignancy in our study was similar to that reported in the literature (2-7%) [10][11][12][13]21,22 and is generally attributed to cytologic misdiagnoses, often in the setting of a follicular variant of a papillary carcinoma. Cytologic diagnosis of this entity can be difficult due to the paucity of nuclear features of papillary carcinomas and the overlapping features with other follicular neoplasms.…”

Section: Discussionsupporting

confidence: 78%

“…This is slightly higher than other recently reported false-positive rates ranging from 4% to 8%. 10,13,14 The main reason for this higher false-positive rate is attributed to the presence of several morphologic features mimicking papillary carcinoma such as intranuclear inclusions, nuclear groove, papillary architecture, and concomitant absence of colloid in the aspirates. These features can be seen in aspirates from Hashimoto's thyroiditis, nodular hyperplasia, follicular adenoma, and Hurthle cell adenoma.…”

Section: Discussionmentioning

confidence: 99%

“…[7][8][9] Despite the increased diagnostic accuracy, USguided FNA still has limitations, such as falsepositive and false-negative results, as well as inadequate sampling. [10][11][12][13][14] In addition, the distinction between a follicular malignancy, such as a follicular carcinoma or a follicular variant of papillary carcinoma, from benign lesions, such as a follicular adenoma or nodular adenomatous goiter, is very limited on cytologic grounds. 15,16 In this study, we analyzed our results of US-guided FNA of thyroid nodules and focused on the discrepancies between cytologic and final pathologic results.…”

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confidence: 99%

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Sonographically guided fine needle aspiration of thyroid nodule: Discrepancies between cytologic and histopathologic findings

Lee

Kim

et al. 2007

J of Clinical Ultrasound

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Purpose. To analyze the discrepancies between the cytologic results of sonographically (US)-guided fine needle aspiration (FNA) of thyroid nodules and final histopathologic results and to discuss the limitations of US-guided FNA.Materials and Methods. The results of US-guided FNAs performed by a single experienced radiologist in 315 thyroid nodules in 292 patients (246 women, 46 men aged 12-79 years) were retrospectively correlated with their surgical pathologic results. The FNA results were classified as nondiagnostic, indeterminate, negative, or positive, whereas final pathologic diagnoses were classified as malignant or benign.Results. The FNA results were nondiagnostic in 31 cases (9.8%), indeterminate in 97 cases (30.8%), and determinate in 187 cases (59.4%). Of the 187 conclusive cases, 169 (90.4%) were concordant with the final pathologic results, whereas 18 (9.6%) were discordant with 14 false-positive and 4 false-negative results. These discrepancies were caused by atypical nuclear features. Among the 97 indeterminate and 31 nondiagnostic cases, a malignancy was found in 14 (14.4%) and 8 (25.8%) cases, respectively. In addition, 10 papillary carcinomas, which were not visualized on sonograms, were detected incidentally in thyroidectomy specimens.Conclusion. The diagnostic accuracy of US-guided FNA of thyroid nodule has limitations that should be minimized by careful interpretation of the cytologic findings and accurate sampling. V V C 2007 Wiley Periodicals, Inc.

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Section: Discussionsupporting

confidence: 78%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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Sonographically guided fine needle aspiration of thyroid nodule: Discrepancies between cytologic and histopathologic findings

Lee

Kim

et al. 2007

J of Clinical Ultrasound

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“…Among solitary thyroid nodules with an indeterminate ("suspicious," "follicular neoplasm," or Hürthle cell neoplasm) biopsy, the risk of malignancy is approximately 20% (90)(91)(92). For solitary nodules that are repeatedly nondiagnostic on biopsy, the risk of malignancy is unknown but is probably closer to 5%-10% (29).…”

Section: What Is the Appropriate Operation For Differentiated Thyroidmentioning

confidence: 99%

Management Guidelines for Patients with Thyroid Nodules and Differentiated Thyroid Cancer: The American Thyroid Association Guidelines Taskforce

Cooper

Doherty

Haugen

et al. 2006

Thyroid

1,894

937

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“…Thyroid nodules are common in the general population and palpable thyroid nodules are present in 4% to 7% of the adult population [1,2]. Autopsy studies have demonstrated a high prevalence of benign nodular thyroid disease [3].…”

Section: Introductionmentioning

confidence: 99%

The Factors Related with Postoperative Complications in Benign Nodular Thyroid Surgery

et al. 2010

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Thyroid gland is an important endocrine organ because of its functions. Although the morbidity and mortality of thyroid surgery have decreased markedly, serious complications may still occur. The aim of this retrospective study was to identify the factors influencing the complications in benign nodular thyroid surgery. A total of 332 patients who underwent thyroid surgery between April 2004 and May 2008 were evaluated retrospectively to identify the factors influencing the complications. We found that in surgery lasting more than 90 minutes the risk of permanent recurrent laryngeal nerve (RLN) injury was high, daily drainage more than 50 cc increases the risk of seroma formation, retrosternal goiter surgery have higher risk for bleeding. The flap edema rates were high found in the operations made by resident surgeon and patients with size 3-4 thyroid glands. Low complication rates can be achieved after thyroidectomy with better knowledge of the surgical anatomy of the neck, thyroid pathology and required surgical treatment.

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Fine-needle aspiration of the thyroid and correlation with histopathology in a contemporary series of 240 patients

Cited by 245 publications

References 22 publications

Sonographically guided fine needle aspiration of thyroid nodule: Discrepancies between cytologic and histopathologic findings

Sonographically guided fine needle aspiration of thyroid nodule: Discrepancies between cytologic and histopathologic findings

Management Guidelines for Patients with Thyroid Nodules and Differentiated Thyroid Cancer: The American Thyroid Association Guidelines Taskforce

The Factors Related with Postoperative Complications in Benign Nodular Thyroid Surgery

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