Fine Needle Aspiration of Metastatic Epithelioid Angiosarcoma

Fulciniti, Franco; Mattia, Diana Di; Bove, Patrizia; Mastro, Angelo Antonio; Chiara, Annarosaria De; Botti, Gerardo; Petrillo, Antonella; Apice, Gaetano

doi:10.1159/000325607

Cited by 20 publications

(13 citation statements)

References 28 publications

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“…The presence of mitotic figures may be more suggestive of EAS versus lower-grade tumors, but they do not appear to be a consistent characteristic among EAS. While many reports do not specifically mention the presence or absence of mitotic figures, mitotic figures were identified in cases in which they were mentioned [29,30]. Common features among many studies include the epithelioid nature of the neoplastic cells as well as the eccentric placement of the nucleus.…”

Section: Discussionmentioning

confidence: 99%

Cytopathologic Characteristics of Epithelioid Vascular Malignancies

et al. 2014

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Objectives: Epithelioid hemangioendothelioma (EHE) and epithelioid angiosarcoma (EAS) are rare vascular neoplasms that share many morphological characteristics on histology but demonstrate different clinical behavior. Given the many reported clinical and morphological features shared between EAS and EHE, we examined all cases of EAS and EHE diagnosed primarily on fine needle aspiration (FNA) at our three institutions that were confirmed by a tissue diagnosis. Study Design: A total of 29 cases from 25 patients were identified: 15 EHE from 11 patients and 14 EAS from 14 patients. Results: Many cytomorphological features existed on a spectrum that overlapped considerably between EAS and EHE cases. Common features between the two entities include epithelioid morphology and eccentrically placed nucleus. Intracytoplasmic lumens (ICL), a morphological feature that may suggest vascular origin, can be found in both entities but are not always present. Conclusions: Given the general absence of vascular cytomorphological features, such as ICL, the proper classification of these tumors depends on the successful use of immunoperoxidase markers such as factor VIII-related antigen, ERG, or CD31 as well as a high index of suspicion. The distinction between EAS and EHE on FNA alone is treacherous at best.

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Section: Discussionmentioning

confidence: 99%

Cytopathologic Characteristics of Epithelioid Vascular Malignancies

et al. 2014

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“…Sometimes, on fine needle aspiration cytology (FNAC) samples, these vascular neoplasms yield a final report of ‘inadequate’ material or may closely mimic a number of different lesions, potentially causing an erroneous cytopathologic diagnosis [15,16]. For this reason, a definitive diagnosis of the angiosarcoma is based mainly on characteristic histopathological features of a malignant vascular tumor and must be supported by detailed investigations (immunopositivity for vascular markers for example, CD31, CD34, factor VIII related antigen, and absence of epithelial markers).…”

Section: Discussionmentioning

confidence: 99%

Primary thyroid angiosarcoma: an unusual localization

Petronella

Scorzelli

Luise³

et al. 2012

World J Surg Onc

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The finding of thyroid nodules is a very common occurrence in routine clinical practice. Approximately 5% to 7% of the entire population have thyroid nodules. Vascular lesions are one of the most controversial issues in thyroid pathology. These include benign lesions such as hemangiomas and, rarely, malignant tumors such as angiosarcomas or undifferentiated angiosarcomatoid carcinomas. In particular, angiosarcoma of the thyroid gland is a rare, highly aggressive malignant vascular tumor and in Italy the greatest geographical incidence of this lesion is witnessed near the Alps. Here, a case of thyroid angiosarcoma in a 71-year-old man with a history of goiter for about 20 years is described. The unusual localization of this lesion, the difficulties in reaching a definitive diagnosis for this particular histological type of primary tumor and a history of long-standing multinodular goiter in thyroid of an older man from outside the Alpine region prompted us to report this case of thyroid angiosarcoma mainly to discuss surgical, histopathological and immunohistochemical features.

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“…It has been more frequently reported in other sites such as the skin 6, uterus 7, small intestine 8, lung 9, thyroid 10, and central nervous system and orbit 11. About 100 cases of secondary angiosarcoma of the breast after breast-conserving therapy have been reported, but primary eas of the breast is rare 12.…”

Section: Introductionmentioning

confidence: 99%

Primary Epithelioid Angiosarcoma of the Breast Masquerading as Carcinoma

et al. 2010

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Here we report a case of primary epithelioid angiosarcoma (eas) of the breast occurring in a 30-year-old woman. Following fine-needle asspiration cytology (fnac) and tru-cut biopsy, the patient was initially diagnosed with mammary carcinoma and thereafter underwent modified radical mastectomy. Postoperative histopathologic examination and immunohistochemistry revealed a diagnosis of primary epithelioid angiosarcoma of the breast. The patient received postoperative radiotherapy to the chest wall and was started on adjuvant thalidomide. Preoperatively, eas can be mistaken for carcinoma because it is difficult to appreciate the typical morphology on fnac or tru-cut biopsy. Indeed, this is an area of potential diagnostic error because, nowadays, neoadjuvant therapy is often instituted after core biopsy of a breast mass. This case is being reported not only for its diagnostic difficulty, but also because of its rarity in English literature.

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Fine Needle Aspiration of Metastatic Epithelioid Angiosarcoma

Cited by 20 publications

References 28 publications

Cytopathologic Characteristics of Epithelioid Vascular Malignancies

Cytopathologic Characteristics of Epithelioid Vascular Malignancies

Primary thyroid angiosarcoma: an unusual localization

Primary Epithelioid Angiosarcoma of the Breast Masquerading as Carcinoma

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