Fine Needle Aspiration of Malignant Bone Lesions

Kabukçuoğlu, Fevziye; Kabukçuoğlu, Yavuz; Kuzgun, Unal; Evren, İ̇smail

doi:10.1159/000331962

Cited by 32 publications

(31 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Non-Hodgkin's lymphoma and metastatic malignancy could be differentiated from Ewing's sarcoma according to these cytomorphologic features. 12,17,18 Positive PAS reaction, seen in most cases in this study, was also an important feature for distinction. 12,17 Differentiation of low-grade CS from chondroma is said to be a difficult task, particularly in certain peripheral bone lesions in which benign chondroma tends to show nuclear atypia and pleomorphism.…”

supporting

confidence: 55%

“…12,17,18 Positive PAS reaction, seen in most cases in this study, was also an important feature for distinction. 12,17 Differentiation of low-grade CS from chondroma is said to be a difficult task, particularly in certain peripheral bone lesions in which benign chondroma tends to show nuclear atypia and pleomorphism. 14,15 Although such nuclear pleomorphism was evident in a few cases of peripheral bone lesions in this study, chondroma in general could be distinguished from low-grade CS ( Figure 6A and B).…”

supporting

confidence: 55%

“…Other studies have mentioned the cytologic categorization of these lesions to correctly point out the primary with variable accuracy. 17,19,20 Cytology smears of myeloma in this series showed typical plasma cells so that correct diagnosis could be made in all of the cases. 17 Serum and urine electrophoresis was helpful in the diagnosis.…”

mentioning

confidence: 69%

See 2 more Smart Citations

Fine Needle Aspiration Cytology of Bone Tumors

2007

View full text Add to dashboard Cite

supporting

confidence: 55%

supporting

confidence: 55%

See 1 more Smart Citation

Fine Needle Aspiration Cytology of Bone Tumors

2007

View full text Add to dashboard Cite

“…DISCUSSION Most studies evaluating the utility of FNA as a diagnostic procedure for osseous lesions have involved predominantly adult patients, in which secondary (metastatic) lesions are more common. In prior studies, FNA alone is reported to have a diagnostic accuracy ranging from 80% 2,8,9 to close to 90% [10][11][12] with osseous lesions. Accuracy is reported as being greater for bone metastases possibly because of prediagnostic clinical suspicion and characteristic radiologic manifestations.…”

Section: Resultsmentioning

confidence: 99%

Optimal Diagnostic Yield Achieved With On-site Pathology Evaluation of Fine-Needle Aspiration–Assisted Core Biopsies for Pediatric Osseous Lesions: A Single-Center Experience

Patel

Kinnear

Quintanilla³

et al. 2017

Archives of Pathology &Amp; Laboratory Medicine

View full text Add to dashboard Cite

Context.-Image-guided, fine-needle aspiration-assisted core needle biopsy with an on-site evaluation by a pathologist (FNACBP) of osseous lesions is not a common practice in pediatric institutions.Objectives.-To evaluate the diagnostic adequacy and accuracy of FNACBP for pediatric osseous lesions and to compare the adequacy with procedures that do not use fine-needle aspiration.Design.-Six-year, retrospective review of 144 consecutive children biopsied for osseous lesions with and without fine-needle aspiration assistance.Results.-Pathologic diagnosis was achieved in 79% (57 of 72) of the core biopsies without an on-site evaluation, 78% (32 of 41) of the open biopsies (9 with intraoperative consultation), and 97% (30 of 31) of the FNACBPs as the initial diagnostic procedure. Three FNACBP cases were preceded by nondiagnostic open biopsies. Among 34 lesions sampled by FNACBP, 33 (97%) succeeded with diagnostic tissue, with most (30 of 33; 91%) being neoplasms, including 16 malignant (48%), 13 benign (39%), and 1 indeterminate (3%) lesions. The mostcommon diagnoses were osteosarcoma (9 of 33; 27%) and Langerhans cell histiocytosis (7 of 33; 21%). In cases with follow-up information available, 93% (28 of 30) of the FNACBP-rendered diagnoses were clinically useful, allowing initiation of appropriate therapy. The FNACBP procedure had 100% specificity, sensitivity, and positive predictive value for all 14 malignant lesions, with the sensitivity being 88% in benign lesions. Most FNACBP procedures (32 of 34; 94%) yielded adequate material for ancillary testing. A gradual upward trend was observed for the choice of FNACBP as an initial diagnostic procedure for osseous lesions.Conclusions.-The FNACBP procedure yields sufficient material for diagnosis and ancillary studies in pediatric, osseous lesions and may be considered an initial-diagnostic procedure of choice.

show abstract

“…Aspiration cytology of osteosarcoma most often reveals an abundance of large, pleomorphic spindle cells with prominent nucleoli. 8 The differential diagnosis may be more difficult in the early reactive and proliferative phase of callus since mitoses and atypical fibroblasts may complicate the cytologic picture. Cartilage may become apparent in the callus but remain limited in amount in the callus of otherwise healthy adults.…”

Section: Discussionmentioning

confidence: 99%