Fine needle aspiration in the diagnosis and classification of hepatoblastoma

Vlajnic, Tatjana; Brisse, H.; Aerts, Isabelle; Fréneaux, Paul; Fabrè, Monique; Klijanienko, Jerzy

doi:10.1002/dc.23642

Cited by 19 publications

(20 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Necrosis was present in cases, regardless of their subtype. Similar cytoplasmic vacuolization was also reported by Vlajnic et al, but necrosis, apoptosis, and mitotic figures were not seen in the fetal component in comparison with the embryonal component. Certain unusual features such as the presence of mast cells, foamy macrophages, and plasmacytoid morphology for fetal cells were observed that have not been reported in the literature.…”

Section: Discussionsupporting

confidence: 88%

“…In the current study, various architectural patterns were identified in HB: trabecular and perivascular patterns were more common in fetal HB, whereas acinar and cluster formation was more common in embryonal HB, as observed in previous studies . The identification of the arrangement of tumor cells in HB aids in differentiating it from childhood HCC.…”

Section: Discussionsupporting

confidence: 79%

“…The identification of the arrangement of tumor cells in HB aids in differentiating it from childhood HCC. Studies have shown the presence of homogeneous, acellular, osteoid‐like material, small fragments of immature bone, and small fascicles of benign spindle cells in fine‐needle aspiration smears . We found a mesenchymal component in the form of spindle cell fragments in approximately 17% of the aspirates; however, an osteoid‐like material was not detected in any of the cases.…”

Section: Discussioncontrasting

confidence: 47%

“…Hepatoblastoma (HB) is the most common primary hepatic tumor of childhood affecting mainly infants and young children . Radiological findings are fairly characteristic for the diagnosis of HB in a background of elevated serum α‐fetoprotein (AFP) . However, fine‐needle aspiration cytology (FNAC) or biopsy is required for a confirmation of the diagnosis and also to rule out other pediatric liver tumors .…”

Section: Introductionmentioning

confidence: 99%

“…Compared with core biopsy, which for subtyping requires multiple needle cores, FNAC is a rapid and safe alternative and samples more tissue from different sites easily. The identification of other pediatric liver tumors such as hepatocellular carcinoma (HCC) can sometimes be difficult in biopsies even with available immunohistochemistry …”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Cytomorphology of hepatoblastoma with histological correlation and role of SALL4 immunocytochemistry in its diagnosis, subtyping, and prognostication

Nakra

Roy

Yadav

et al. 2019

Cancer Cytopathology

View full text Add to dashboard Cite

Background Hepatoblastoma (HB) is the most common malignant pediatric liver tumor, and cytology material is often the only tissue available for evaluation before definitive therapy. Subcategorization of HB based on cytomorphological features thus carries an important role in its prognostication. Spalt‐like transcription factor 4 (SALL4), a marker of embryonic stem cells that is also found in the fetal liver, is reactivated in certain liver tumors. Limited studies have evaluated its role in HB. This study was aimed at evaluating the cytomorphological features of HB and assessing the utility of SALL4 immunocytochemistry (ICC) in its subtyping and prognostication. Methods Pretherapy fine‐needle aspiration smears from patients diagnosed with HB over a period of 9 years were retrieved. Aspirates were subclassified on the basis of the cytomorphology and were correlated with the histology wherever it was available. ICC for SALL4 was performed in 33 cases, and nuclear staining was considered positive. Results A total of 53 HB cases were included with 30 available postchemotherapy resection specimens. All the patients were diagnosed as epithelial HB on cytology, and the cases were subclassified as pure fetal (9 of 53), pure embryonal (2 of 53), or combined epithelial HB (42 of 53). There was good concordance between cytology and histology for subtyping. SALL4 immunostaining displayed strong and diffuse nuclear positivity in the embryonal component while focal and weak to negative staining in fetal cells. Conclusions Fine‐needle aspiration cytology serves as a rapid and effective tool for a correct diagnosis of HB before the implementation of chemotherapy, and SALL4 may serve as a useful diagnostic and prognostic marker.

show abstract

Section: Discussionsupporting

confidence: 88%

Section: Discussionsupporting

confidence: 79%

Section: Discussioncontrasting

confidence: 47%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Cytomorphology of hepatoblastoma with histological correlation and role of SALL4 immunocytochemistry in its diagnosis, subtyping, and prognostication

Nakra

Roy

Yadav

et al. 2019

Cancer Cytopathology

View full text Add to dashboard Cite

show abstract

Cytologic features of malignant rhabdoid tumor of the liver: A case report and literature review

Liu

Bruner

Yang

2021

Diagnostic Cytopathology

View full text Add to dashboard Cite

As one of the SMARCB1‐deficient tumors, malignant rhabdoid tumor (MRT) of the liver is a rare and aggressive malignancy, typically in young children below the age of 3 years. The diagnosis of MRT of the liver is challenging both clinically and pathologically due to the rarity of the tumor and misdiagnosing it as a hepatoblastoma is not uncommon. Although MRT of the liver and hepatoblastoma share some similar clinical and morphological features, their prognosis and the clinical management are significantly different. Therefore, an accurate diagnosis of MRT or hepatoblastoma is critical for patient care. Here we report a case of an 8‐month‐old female with MRT of the liver diagnosed by fine needle aspiration and core biopsy. The cytologic and histological features, the results of immunohistochemical studies, and clinical follow‐up information are presented. Recent literature regarding the diagnosis and treatment of this tumor were reviewed.

show abstract

Malignant rhabdoid tumour of liver: Conundrum on ascitic fluid

Sharma

Thirunavukkarasu

Nalwa

et al. 2023

Diagnostic Cytopathology

View full text Add to dashboard Cite

Ascitic fluid analysis is an important tool for diagnosis and staging. Cytological analysis is routinely done as a part of workup for ascites. This is challenging in paediatric malignancies where multiple differentials need to be considered at times with limited cellularity. We present a case of malignant rhabdoid tumour of liver in a young child presenting with abdominal lump and ascites. The diagnosis was offered on ascitic fluid cytology based on cytomorphology, supporting immunohistochemistry and later confirmed on biopsy. This report briefly discusses its differentials and approach to diagnosis.

show abstract

Fine needle aspiration in the diagnosis and classification of hepatoblastoma

Abstract: FNA allows to accurately diagnose HBL and recognize its histological subtypes. On the basis of high concordance between cytological and histological diagnosis, FNA is validated as an alternative diagnostic method to CNB. Diagn. Cytopathol. 2017;45:91-100. © 2016 Wiley Periodicals, Inc.

Cited by 19 publications

References 32 publications

Cytomorphology of hepatoblastoma with histological correlation and role of SALL4 immunocytochemistry in its diagnosis, subtyping, and prognostication

Cytomorphology of hepatoblastoma with histological correlation and role of SALL4 immunocytochemistry in its diagnosis, subtyping, and prognostication

Cytologic features of malignant rhabdoid tumor of the liver: A case report and literature review

Malignant rhabdoid tumour of liver: Conundrum on ascitic fluid

Contact Info

Product

Resources

About