Fine Needle Aspiration Diagnosis of Carotid Body Tumor in a Case of Multiple Paragangliomas Presenting with Facial Palsy

Naniwadekar, M R; Jagtap, Sunil Vitthalrao; Kshirsagar, Ashok Y; Shinagare, Shweta; Tata, Hoshedar Ramyar; Sahoo, Kulamani

doi:10.1159/000325191

Cited by 7 publications

(5 citation statements)

References 4 publications

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“…Physicians should delay the use of corticosteroids given the spontaneous improvement of the carotid inflammation in most cases after discontinuation of the causative treatment. 1 Four diagnostic criteria are necessary for the diagnosis of TIPIC 4 : occurrence of pain in the area of the carotid bifurcation, of acute onset (1), visualization of perivascular infiltrative tissue on imaging (2), exclusion of different vascular or nonvascular entities based on imaging findings (3), and improvement of clinical and imaging findings within 2 weeks spontaneous or with the use of anti-inflammatory medication (4). Our patient met the four criteria.…”

Section: Discussionmentioning

confidence: 99%

“…In carotid occlusion, rare cause of multiple paraganglioma of carotid is to be ruled out. 4 Recent guidelines were established by the Society for Vascular Surgery for management of extracranial cerebrovascular disease. These guidelines concern management of carotid stenosis in stroke prevention, and indication of invasive technique should consider neurological symptoms, degree of carotid stenosis, medical comorbidities, and vascular and morphological features.…”

Section: Discussionmentioning

confidence: 99%

“…The differential diagnosis of acute cervical pain includes nonvascular and vascular causes such as carotid dissection, carotid occlusion, or vasculitis. In carotid occlusion, rare cause of multiple paraganglioma of carotid is to be ruled out 4 …”

Section: Discussionmentioning

confidence: 99%

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G‐CSF‐induced TIPIC syndrome and large vessel vasculitis: A case report

Arnould,

Miranda,

Mignon

et al. 2023

Clinical Case Reports

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Key Clinical MessageWe report a rare adverse event of transient perivascular inflammation of the carotid artery syndrome induced by granulocyte colony‐stimulating factor injections. Recognition of this syndrome is important for physicians, to avoid the exposure of the causative medication, rule out differential diagnosis and delay the use of corticosteroids given the spontaneous improvement after discontinuation of the causative medication.AbstractA 73 year‐old Caucasian woman presented with odynophagia, carotidynia, and fever 5 days following a granulocyte colony‐stimulating factor (G‐CSF) injection for chemotherapy‐induced neutropenia in the setting of myelodysplastic syndrome. Examination showed painful swelling of the neck. Lab results showed inflammation with CRP 328 mg/L. A CT‐scan revealed tissue infiltration thickening surrounding the left internal carotid artery, the carotid bifurcation, and the common carotid artery, as well as circumferential thickening of the aortic arch. Ultrasound of the left internal carotid artery found isoechoic wall thickening. Symptoms drastically improved without steroids in a short time period. Horton's disease, Takayasu's diseases, and infectious vasculitis were not retained due to the short time delay of symptoms onset, atypical echogenicity, and spontaneous improvement. A diagnosis of G‐CSF‐induced large vessel vasculitis transient perivascular inflammation of the carotid artery (TIPIC) syndrome was made. Seven days later, ultrasound control showed diminished thickening infiltration. G‐CSF TIPIC is a rare adverse event that should be kept in mind in patients under G‐CSF.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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G‐CSF‐induced TIPIC syndrome and large vessel vasculitis: A case report

Arnould,

Miranda,

Mignon

et al. 2023

Clinical Case Reports

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“…When compared with the knobby oval- to spindle-shaped tumor cells of SFT/HPC, the cytology of glomus tumor or glomangiopericytoma is characterized by a fine vasculature surrounded by monotonous round cells with punched out nuclei and amphophilic cytoplasm with an indistinct cell border. Paraganglioma cytology also shows round cells with moderate nuclear pleomorphism and fine granular cytoplasm enveloped by thin vessels [17].…”

Section: Discussionmentioning

confidence: 99%

Frozen Cytology of Meningeal Malignant Solitary Fibrous Tumor/Hemangiopericytoma

Kang

Kim

Chung

et al. 2019

J Pathol Transl Med

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A 51-year-old woman presented with severe dizziness. The brain magnetic resonance image revealed a 5.5 cm multiloculated mass with a thick rim in the left temporal lobe. Cytological examination of frozen diagnosis of the mass showed hypercellular sheets of round and rhabdoid cells in a hemorrhagic background, and two mitotic figures were observed. Histologically, the excised dura-based mass consisted of predominantly round cells with small foci of rhabdoid tumor cells in a pseudoalveolar pattern in a hemorrhagic background, and the cells showed nuclear positivity for signal transducer and activator of transcription 6 as well as frequent mitosis. The mass was diagnosed as a grade 3 solitary fibrous tumor (SFT)/hemangiopericytoma (HPC). The cytological diagnosis of SFT/HPC is challenging because of the heterogeneous cytological findings, such as histological heterogeneity, and because there are no standardized cytological criteria for malignant SFT/HPC. Cytological findings, such as singly scattered small cells, hypercellularity, rare ropy collagen, and round and rhabdoid cells with pseudoalveolar pattern, may assist in the diagnosis of malignant SFT/HPC.

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“…Follicular neoplasms have in common high cellularity, scant or absent colloid, and follicular cells with enlarged nuclei arranged in syncytial groups, displaying nuclear crowding and overlapping. The follicular arrangement of the tumor cells may suggest a follicular neoplasm, but in follicular neoplasms, the cells are more closely packed and the nuclei are more uniform in size …”

Section: Discussionmentioning

confidence: 99%

Thyroid Paraganglioma Diagnosed by Fine‐Needle Aspiration Biopsy, Correlated With Histopathological Findings: Report of a Case

Cetin

Gozde

Yilmaz

2016

Diagnostic Cytopathology

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Thyroid paragangliomas are rare neuroendocrine tumors. They are difficult to diagnosis by fine-needle aspiration biopsy (FNAB) and can be misdiagnosed as other types of thyroid disease. Here, we present an unusual case of primary thyroid paraganglioma diagnosed by FNAB. A 66-year-old woman presented with multinodular goiter. Ultrasound (US)-guided FNAB of the 3 cm nodule in the superior portion of the right lobe of the thyroid was performed. The cytological smears showed single cells or loose clusters of round to ovoid cells with oval granular nuclei. To differentiate between thyroid paraganglioma and other thyroid neoplasms, cell block material from the FNAB specimen was immunohistochemically stained with antibodies to thyroglobulin, calcitonin (CT), AE1-AE3, carcinoembryonic antigen (CEA), synaptophysin, chromogranin A (CH-A), neuron-specific enolase (NSE), thyroid transcription factor-1 (TTF-1), parathyroid hormone (PTH), and S-100. Immunohistochemical staining was positive for synaptophysin, CH-A, NSE, and S-100, and negative for thyroglobulin, CT, AE1-AE3, PTH, CEA, and TTF-1. Congo red staining was also negative. Paraganglioma and other neuroendocrine neoplasms were considered in the differential diagnosis. A total thyroidectomy was performed, and a final diagnosis of paraganglioma was made. Paraganglioma is a rare neuroendocrine tumor of the thyroid and should be considered in the differential diagnosis based on cytology of thyroid neuroendocrine tumors. Immunohistochemistry should be performed when making a diagnosis of thyroid paraganglioma, particularly when evaluating fine-needle aspiration smears. Diagn. Cytopathol. 2016;44:643-647. © 2016 Wiley Periodicals, Inc.

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Fine Needle Aspiration Diagnosis of Carotid Body Tumor in a Case of Multiple Paragangliomas Presenting with Facial Palsy

Cited by 7 publications

References 4 publications

G‐CSF‐induced TIPIC syndrome and large vessel vasculitis: A case report

G‐CSF‐induced TIPIC syndrome and large vessel vasculitis: A case report

Frozen Cytology of Meningeal Malignant Solitary Fibrous Tumor/Hemangiopericytoma

Thyroid Paraganglioma Diagnosed by Fine‐Needle Aspiration Biopsy, Correlated With Histopathological Findings: Report of a Case

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