Fine Needle Aspiration Diagnosis of Transitional Cell Carcinoma Metastatic to the Brain

Girgis, Safwat; Ramzy, Ibrahim; Baer, S.; Schwartz, Mary R.

doi:10.1159/000330984

Cited by 8 publications

(3 citation statements)

References 7 publications

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“…89 In a case report of FNA of a brain metastasis of transitional cell Ca, apoptotic bodies were frequently seen. 90 Thyroid p53 was investigated in 15 thyroid FNAs (polyclonal antiserum CM-1). One of one follicular carcinoma, one of two papillary carcinomas were p53 positive.…”

Section: Urinary Tractmentioning

confidence: 99%

Evaluation of apoptosis in cytologic specimens

Shtilbans¹,

Burstein

2010

Diagnostic Cytopathology

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A hallmark of neoplasia is dysregulated apoptosis, programmed cell death. Apoptosis is crucial for normal tissue homeostasis. Dysregulation of apoptotic pathways leads to reduced cytocidal responses to chemotherapeutic drugs or radiation and is a frequent contributor to therapeutic resistance in cancer. The literature pertaining to detection of apoptotic pathway constituents in cytologic specimens is reviewed herein. Virtually all methods for detecting apoptosis, including classic cytomorphologic evaluation, TUNEL assay, immunocytochemistry, and gene sequence analysis, may be applied to cytologic samples as well as tissue. Components of both intrinsic and extrinsic apoptotic pathways have been studied, including many reports examining p53 and bcl-2, as well as studies of caspase inhibitory proteins XIAP and survivin, death receptors and ligands such as Fas, Fas-ligand, and TRAIL. p53 undergoes oncogenic alteration more than any other protein; its immunocytochemical detection almost always connotes loss of its physiologic role as an inducer of apoptosis in response to a damaged genome. Several reports establish cytologic sampling as being as useful as tissue sampling. In one respect cytologic sampling is superior to tissue sampling in particular, by allowing clinicians to repeat sampling of the same tumor before and after administration of therapy; a number of reports use this approach to attempt to predict tumor response by assaying the effect of chemotherapy on the induction of apoptosis.

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Section: Urinary Tractmentioning

confidence: 99%

Evaluation of apoptosis in cytologic specimens

Shtilbans¹,

Burstein

2010

Diagnostic Cytopathology

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“…Of these, the clinical presentation of central nervous system symptoms from intracranial metastasis preceded the diagnosis of urinary bladder cancer in 11 cases (20.4%). [1214171929404471747882] The distribution among all cases tended to be skewed toward males and single or solitary lesions over multiple metastases. Metastasis to the frontal lobe seemed to be the most common location of single or solitary lesions, followed by the temporal and parietal lobes.…”

Section: Discussionmentioning

confidence: 99%

Solitary cerebral metastasis from transitional cell carcinoma after a 14-year remission of urinary bladder cancer treated with gemcitabine: Case report and literature review

Jm¹,

Ms²,

Z³

et al. 2012

Surg Neurol Int

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Background:Brain metastases are the most common adult brain tumors, frequently arising from primary tumors in the lung, breast, skin, kidneys, and colon. Transitional cell carcinoma (TCC), the most common type of urinary bladder cancer, is a rare cause of brain metastasis with an ominous prognosis.Case Description:A 68-year-old female presented with right-sided paresis and focal motor seizures of her right upper and lower extremities 14 years after being diagnosed and treated for primary TCC of the urinary bladder with gemcitabine-based chemotherapy. MRI imaging revealed a 3.1 × 3.1 × 2.7 cm heterogeneously enhancing mass located along the posterior aspect of the left frontal convexity. The lesion was accessed using a transsulcal approach and was surgically debulked along the motor cortex with motor strip mapping, followed by adjuvant whole-brain radiation therapy. Pathological examination confirmed metastatic carcinoma with features of TCC, a rare entity among metastatic brain tumors.Conclusion:Brain metastases may present several years later in patients with TCC of the urinary bladder who have been treated with surgery and chemotherapy. Chemotherapeutic agents that penetrate the blood–brain barrier, such as gemcitabine, may delay development of cerebral metastasis from primary TCC of the urinary bladder.

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“…In a case report of FNA of a brain metastasis of transitional cell Ca, apoptotic bodies were frequently seen 90…”

Section: Apoptosis In Cytological Specimens From Specific Tissuesmentioning

confidence: 99%

Chemotherapy with rituximab followed by high‐dose therapy and autologous stem cell transplantation in patients with mantle cell lymphoma

Thiéblemont

Antal

Lacotte‐Thierry

et al. 2005

Cancer

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A hallmark of neoplasia is dysregulated apoptosis, programmed cell death. Apoptosis is crucial for normal tissue homeostasis. Dysregulation of apoptotic pathways leads to reduced cytocidal responses to chemotherapeutic drugs or radiation and is a frequent contributor to therapeutic resistance in cancer. The literature pertaining to detection of apoptotic pathway constituents in cytologic specimens is reviewed herein. Virtually all methods for detecting apoptosis, including classic cytomorphologic evaluation, TUNEL assay, immunocytochemistry, and gene sequence analysis, may be applied to cytologic samples as well as tissue. Components of both intrinsic and extrinsic apoptotic pathways have been studied, including many reports examining p53 and bcl‐2, as well as studies of caspase inhibitory proteins XIAP and survivin, death receptors and ligands such as Fas, Fas‐ligand, and TRAIL. p53 undergoes oncogenic alteration more than any other protein; its immunocytochemical detection almost always connotes loss of its physiologic role as an inducer of apoptosis in response to a damaged genome. Several reports establish cytologic sampling as being as useful as tissue sampling. In one respect cytologic sampling is superior to tissue sampling in particular, by allowing clinicians to repeat sampling of the same tumor before and after administration of therapy; a number of reports use this approach to attempt to predict tumor response by assaying the effect of chemotherapy on the induction of apoptosis. Diagn. Cytopathol. 2010;38:685–697. © 2010 Wiley‐Liss, Inc.

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Fine Needle Aspiration Diagnosis of Transitional Cell Carcinoma Metastatic to the Brain

Cited by 8 publications

References 7 publications

Evaluation of apoptosis in cytologic specimens

Evaluation of apoptosis in cytologic specimens

Solitary cerebral metastasis from transitional cell carcinoma after a 14-year remission of urinary bladder cancer treated with gemcitabine: Case report and literature review

Chemotherapy with rituximab followed by high‐dose therapy and autologous stem cell transplantation in patients with mantle cell lymphoma

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