Fine needle aspiration cytology of undifferentiated embryonal sarcoma of the liver

Gupta, Charu; Iyer, V. K.; Kaushal, Seema; Agarwala, Sandeep; Mathur, Sandeep

doi:10.1111/j.1365-2303.2009.00732.x

Cited by 9 publications

(8 citation statements)

References 10 publications

(20 reference statements)

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“…HB is the most common primary hepatic tumor of childhood but needs to be distinguished from other rarer pediatric liver tumors . The diagnosis of HB can be suspected on the basis of clinical presentation, radiological features, and raised serum AFP levels.…”

Section: Discussionmentioning

confidence: 99%

“…Cytokeratin and AFP levels are not useful; hence, an acinar arrangement and EMH are the main features apart from the finer morphological details of embryonal cells described previously. The presence of bizarre giant cells is very rare and is described more commonly in undifferentiated embryonal sarcoma of the liver (a tumor with a mesenchymal morphology that also shows mucoid material and tumor cell spindling) or HCC . The small cell undifferentiated type of HB is diagnosed if cytokeratin is positive, AFP is low, and SALL4 is negative; this contrasts with embryonal cells, which are also cytokeratin positive but show an AFP elevation, an acinar arrangement, and strong SALL4 positivity.…”

Section: Discussionmentioning

confidence: 99%

“…HB is the most common primary hepatic tumor of childhood but needs to be distinguished from other rarer pediatric liver tumors. 3,11,[15][16][17] The diagnosis of HB can be suspected on the basis of clinical presentation, radiological features, and raised serum AFP levels. However, a precise pathological diagnosis, including tumor subtyping and prognostic morphological features, is essential for therapeutic purposes.…”

Section: Discussionmentioning

confidence: 99%

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Cytomorphology of hepatoblastoma with histological correlation and role of SALL4 immunocytochemistry in its diagnosis, subtyping, and prognostication

Nakra

Roy

Yadav

et al. 2019

Cancer Cytopathology

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Background Hepatoblastoma (HB) is the most common malignant pediatric liver tumor, and cytology material is often the only tissue available for evaluation before definitive therapy. Subcategorization of HB based on cytomorphological features thus carries an important role in its prognostication. Spalt‐like transcription factor 4 (SALL4), a marker of embryonic stem cells that is also found in the fetal liver, is reactivated in certain liver tumors. Limited studies have evaluated its role in HB. This study was aimed at evaluating the cytomorphological features of HB and assessing the utility of SALL4 immunocytochemistry (ICC) in its subtyping and prognostication. Methods Pretherapy fine‐needle aspiration smears from patients diagnosed with HB over a period of 9 years were retrieved. Aspirates were subclassified on the basis of the cytomorphology and were correlated with the histology wherever it was available. ICC for SALL4 was performed in 33 cases, and nuclear staining was considered positive. Results A total of 53 HB cases were included with 30 available postchemotherapy resection specimens. All the patients were diagnosed as epithelial HB on cytology, and the cases were subclassified as pure fetal (9 of 53), pure embryonal (2 of 53), or combined epithelial HB (42 of 53). There was good concordance between cytology and histology for subtyping. SALL4 immunostaining displayed strong and diffuse nuclear positivity in the embryonal component while focal and weak to negative staining in fetal cells. Conclusions Fine‐needle aspiration cytology serves as a rapid and effective tool for a correct diagnosis of HB before the implementation of chemotherapy, and SALL4 may serve as a useful diagnostic and prognostic marker.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Cytomorphology of hepatoblastoma with histological correlation and role of SALL4 immunocytochemistry in its diagnosis, subtyping, and prognostication

Nakra

Roy

Yadav

et al. 2019

Cancer Cytopathology

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“…Liver FNAC in most pediatric cases is done for urgent diagnosis and early therapeutic intervention. 1,2 Mesenchymal hamartomas are a part of non-vascular mesenchymal tumours and tumour-like lesions. They are the second most common benign hepatic tumours occurring exclusively during infancy and childhood.…”

Section: Discussionmentioning

confidence: 99%

“…These require radical surgical excision to avoid local recurrence and possible malignant transformation. 1,2 Benign liver masses have always been a diagnostic challenge in cytology. Diagnosis of such entities require meticulous examination and a sound knowledge of the cytological features of the benign entities presenting as large liver masses in children is essential for the same.…”

Section: Introductionmentioning

confidence: 99%

Fine needle aspiration cytology of mesenchymal hamartoma of liver mimicking hepatoblastoma: A case report

Thakur

Yadav

Agarwala

et al. 2021

Diagnostic Cytopathology

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Fine-needle aspiration cytology (FNAC) is an effective tool for early and quick diagnosis of malignant and metastatic liver masses. However, diagnosing a benign liver tumor on cytology is a challenging task as they are rarely assessed on cytology and also due to the limitations of the procedure. Mesenchymal hamartoma is an uncommon benign pediatric liver tumor and difficult to diagnose on cytology. We describe here a case of a child who presented with a huge liver mass and clinical suspicion of hepatoblastoma. The child underwent blind FNA, and was diagnosed as mesenchymal hamartoma based on the cytological features. A biopsy was performed subsequently which confirmed the same and then he underwent surgical resection of the tumor.The patient had an uneventful recovery and is disease free on follow up.

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Liver

Bode‐Lesniewska¹,

Domański²

2013

Atlas of Fine Needle Aspiration Cytology

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Fine needle aspiration cytology of undifferentiated embryonal sarcoma of the liver

Cited by 9 publications

References 10 publications

Cytomorphology of hepatoblastoma with histological correlation and role of SALL4 immunocytochemistry in its diagnosis, subtyping, and prognostication

Cytomorphology of hepatoblastoma with histological correlation and role of SALL4 immunocytochemistry in its diagnosis, subtyping, and prognostication

Fine needle aspiration cytology of mesenchymal hamartoma of liver mimicking hepatoblastoma: A case report

Liver

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