Fine-needle aspiration cytology of recurrent epithelioid sarcoma of the foot: Role of immonocytochemistry in definitive diagnosis

Kulkarni, M. L.; Deshmukh, Sanjay D; Patil, Vinod R; Khandeparkar, Siddhi Gaurish Sinai

doi:10.4103/0970-9371.151131

Cited by 6 publications

(14 citation statements)

References 8 publications

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“…Dispersed neoplastic cells were dominant, followed by loosely cohesive cell clusters. The main cell population in the majority of cases was formed by large, round, or polygonal cells, in between which spindle cells were observed in some cases . Only in single cases were spindle cells noted to be the main population .…”

Section: Discussionmentioning

confidence: 94%

“…Some cases presented with conspicuous nucleoli . In some cases, rhabdoid cells were identified, but these were dominant in single smears only . In one case, numerous stripped nuclei were observed .…”

Section: Discussionmentioning

confidence: 96%

“…In a sizeable number of the reports, the nuclei were located eccentrically, which determined the plasmacytoid appearance of the cells, and in some cases the cells were binucleated or multinucleated . Some cases presented with conspicuous nucleoli . In some cases, rhabdoid cells were identified, but these were dominant in single smears only .…”

Section: Discussionmentioning

confidence: 99%

“…To our knowledge to date, fewer than 50 ES cases diagnosed using fine‐needle aspiration (FNA) have been reported in the literature and diagnosed using fine‐needle aspiration (FNA), but only a few were classified as being of classic or proximal type.…”

Section: Introductionmentioning

confidence: 99%

“…To our knowledge to date, fewer than 50 ES cases diagnosed using fine-needle aspiration (FNA) have been reported in the literature [7][8][9][10][11][12][13][14][15][16][17][18] but only a few 10,12,15,17,18 were classified as being of classic or proximal type.…”

Section: Introductionmentioning

confidence: 99%

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FNA of epithelioid sarcoma: Curie Institute experience and critical review of the literature

Gajdzis

Laé

Klijanienko

2018

Cancer Cytopathology

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BACKGROUND Epithelioid sarcoma (ES) is a rare mesenchymal tumor that is divided into 2 types: classic and proximal. To the authors’ knowledge, ES has been poorly studied in cytology, with fewer than 50 cases reported to date. The objective of the current study was to analyze the cytological and immunohistochemical information regarding 5 cases of ES. METHODS Five cases of ES were analyzed: 4 of proximal type and 1 of classic type. The cases were taken from 4 female patients and 1 male patient. The patients ranged in age from 10 to 75 years. RESULTS All smears obtained from the proximal type of ES were found to be hypercellular with a necrotic and inflammatory background. Smears from classic‐type ES were hypocellular with a hemorrhagic background. Large, dispersed epithelioid cells and loosely cohesive groups of cells were most frequently noted in all cases. All cases of proximal‐type ES demonstrated rhabdoid cells and marked nuclear atypia, but in only one case were rhabdoid cells found to be dominant. ES diagnoses were confirmed by immunohistochemistry in histological material. In 4 cases, epithelial marker expression was noted, whereas CD34 was found to be positive in only the classic type of ES. In 2 cases, total loss of SMARCB1/INI1 nuclear expression was observed. In the 2 SMARCB1/INI1–positive cases, loss of SMARCA2/BRM expression was observed in one case and partial loss was observed in the other case. CONCLUSIONS The proximal type of ES differs from the classic type by the presence of rhabdoid cells and marked nuclear atypia. A specific immunohistochemical profile demonstrating loss of SMARCB1/INI1 or other proteins from the SWI/SNF complex also may be indicative of this diagnosis.

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Section: Discussionmentioning

confidence: 94%

Section: Discussionmentioning

confidence: 96%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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FNA of epithelioid sarcoma: Curie Institute experience and critical review of the literature

Gajdzis

Laé

Klijanienko

2018

Cancer Cytopathology

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Spectrum of cytopathologic features of epithelioid sarcoma in a series of 7 uncommon cases with immunohistochemical results, including loss of INI1/SMARCB1 in two test cases

Rekhi

Singh

2016

Diagnostic Cytopathology

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Diagnosis of an epithelioid sarcoma (ES) is challenging on fine needle aspiration cytology (FNAC) smears. There are few documented series describing cytopathologic features and immunostaining results of ESs. The present study describes cytopathologic features of seven cases of ES. All seven tumors occurred in males within age-range of 22-61 years; in sites, such as forearm (n = 3), hand (n = 2), thigh (n = 1), and inguinal region (n = 1). FNAC was performed for metastatic lesions (n = 5), recurrent lesions (n = 4), as well as for a primary diagnosis (n = 1). FNAC smears in most cases were moderate to hypercellular, composed of polygonal cells(seven cases) and spindle cells(three cases), arranged in loosely cohesive groups, non-overlapping clusters, and scattered singly, containing moderate to abundant cytoplasm, defined cell borders, vesicular nuclei, and discernible nucleoli. Variable cytopathologic features identified in certain cases were "rhabdoid-like" intracytoplasmic inclusions (n = 5), giant cells (n = 3), and interspersed scanty, metachromatic stroma (n = 4). Histopathologic examination revealed two cases of conventional-type ES, three of proximal/large cell-type ES, and two cases of mixed-type ES, displaying features of conventional and proximal subtypes. By immunohistochemistry (IHC), tumor cells were positive for cytokeratin (CK)(4/5), epithelial membrane antigen (EMA) (6/6), panCK (1/1), vimentin (3/3), and CD34 (7/7). Tumor cells were completely negative for INI1/SMARCB1 (0/2) and CD31 (0/5). In our settings, FNAC was mostly performed in recurrent and/or metastatic cases of ES, and rarely for a primary diagnosis of ES. Important cytopathologic features of ESs include loosely cohesive, non-overlapping clusters of polygonal cells with variable "rhabdoid-like" and spindle cells. Optimal diagnostic IHC markers in such cases include CK, EMA, AE1AE3, CD34, and INI1/SMARCB1. Clinical correlation is imperative in all cases. Diagn. Cytopathol. 2016;44:636-642. © 2016 Wiley Periodicals, Inc.

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Metastatic hepatocellular carcinoma masquerading as soft tissue sarcoma: A diagnostic challenge

Gochhait

Dehuri

Rangarajan

et al. 2018

Diagnostic Cytopathology

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Fine-needle aspiration cytology of recurrent epithelioid sarcoma of the foot: Role of immonocytochemistry in definitive diagnosis

Cited by 6 publications

References 8 publications

FNA of epithelioid sarcoma: Curie Institute experience and critical review of the literature

FNA of epithelioid sarcoma: Curie Institute experience and critical review of the literature

Spectrum of cytopathologic features of epithelioid sarcoma in a series of 7 uncommon cases with immunohistochemical results, including loss of INI1/SMARCB1 in two test cases

Metastatic hepatocellular carcinoma masquerading as soft tissue sarcoma: A diagnostic challenge

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