Fine needle aspiration cytology of follicular variant of papillary carcinoma of thyroid

Powari, Manish; Dey, Pranab; Saikia, Uma Nahar

doi:10.1046/j.1365-2303.2003.00056.x

Cited by 30 publications

(27 citation statements)

References 5 publications

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“…It has been reported to cause a large proportion of false-negative results in thyroid FNA, with sensitivities ranging from 9 to 37%, and it has been shown that its cytological findings more likely fall into the lower-risk category in comparison to the classical variant [7,9,11,13,14,15]. …”

Section: Discussionmentioning

confidence: 99%

Cytological Diagnosis of Follicular Variant of Papillary Thyroid Carcinoma before and after the Bethesda System for Reporting Thyroid Cytopathology

et al. 2016

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Background: The follicular variant of papillary thyroid carcinoma (FVPTC) is the second most common subtype of papillary carcinoma after the classical variant. The Bethesda System for Reporting Thyroid Cytopathology (TBSRTC) has been introduced to standardize the practice of thyroid fine needle aspiration (FNA) reporting. We evaluated the impact of TBSRTC on the FNA interpretation of histologically proven FVPTCs. Method: Cytology reports of 455 histologically proven FVPTCs were reviewed. The rate of each TBSRTC category was compared between pre- and post-TBSRTC eras. Results: The distribution of FNA diagnoses for pre-TBSRTC cases included suspicious for follicular neoplasm (SFN; n = 51, 28.7%), papillary thyroid carcinoma (PTC; n = 47, 26.4%), suspicious for malignancy (SFM; n = 32, 18%), atypia of undetermined significance (AUS; n = 23, 13%), benign (n = 18, 10.1%), and nondiagnostic (ND; n = 7, 4%). Post-TBSRTC diagnoses were: AUS (n = 68, 24.6%), PTC (n = 64, 23.1%), SFM (n = 50, 18%), SFN and benign (n = 42, 15.2%) and ND (n = 11, 4%). SFN rate decreased significantly from 28.7 to 15.2% (p = 0.001) and AUS increased from 12.9 to 24.5% (p = 0.003). Conclusion: Following implementation of TBSRTC, the frequency of AUS diagnoses on FNA prior to surgical resection increased. Given that the rate of FVPTC diagnoses on thyroidectomy increased over the same period, this suggests that the use of AUS has resulted in greater surgical resection of FVPTC.

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Section: Discussionmentioning

confidence: 99%

Cytological Diagnosis of Follicular Variant of Papillary Thyroid Carcinoma before and after the Bethesda System for Reporting Thyroid Cytopathology

et al. 2016

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“…Unlike papillary thyroid carcinoma, preoperative diagnosis of follicular thyroid carcinoma with FNAC is difficult [17,19]. Capsule and vascular invasion are the main characteristic differences between thyroid follicular adenoma and carcinoma.…”

Section: Discussionmentioning

confidence: 99%

Follicular Thyroid Carcinomas with Lung Metastases: A 23-Year Retrospective Study

Lin

Chao

2004

Endocr J

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Abstract. Limited clinical information is specified in the presentations, results of treatment and prognostic factors of follicular thyroid carcinoma with lung metastases. In order to better characterize the information, we retrospectively analyzed the data of 2,003 thyroid cancer patients who received treatment and follow-up at the Chang Gung Memorial Hospital during the period from January 1979 to December 2002. There were 1,516 cases of papillary and 272 cases of follicular thyroid carcinomas. In the study, lung metastases of the follicular thyroid carcinomas were defined as postoperative or follow-up chest X-ray, diagnostic or therapeutic 131 I scan with positive finding of lung metastases. Serum thyroglobulin (Tg) levels under thyroxine treatment of patients with lung metastases had to be over 1.5 ng/mL. Of the follicular thyroid carcinomas, there were 70 (25.7%) with lung metastases including 50 females (mean age 54.1 ± 12.6 years old) and 20 males (mean age 59.4 ± 12.0 years old). Of the 70 patients, there were 53 patients (75.7%) who presented with lung metastases at the time of diagnosis. Of the 70 patients of follicular thyroid carcinoma with lung metastases, 30 patients (42.9%) died at the end of the follow-up, and only 4 patients improved to disease free status. The 5, 10, 15, and 20 year survival rates in these patients were 68.5%, 54.0%, 41.6%, 27.7%, respectively. Age, post-operative Tg level and tumor size are important prognostic factors which are demonstrated to be significantly different statistically between lung metastases group and the group of the patients without distant metastasis. Otherwise, only the tumor size and accumulative dose of 131 I therapy demonstrate a significant difference between survival and mortality groups. Seventeen of the 70 patients developed lung metastases during the follow-up period. Mean period between diagnosis and recurrence of these patients was 3.6 ± 0.9 years. Over 75% of follicular thyroid carcinoma with lung metastases was diagnosed at the time of presentation. Forty percent (28/70 cases) of the follicular thyroid carcinoma with lung metastases had history of thyroid surgery in this study. If lung metastases are diagnosed in follicular thyroid carcinoma, it will be followed by a poor prognosis. Older patients, higher postoperative Tg, and larger tumor size in follicular thyroid carcinoma need aggressive postoperative treatment. MOST well differentiated thyroid cancer cases progress slowly in their clinical courses [1][2][3]. Around 8 to 33% of the follicular thyroid carcinoma patients presented with distant metastases at the time of diagnosis [4][5][6]. In our recent study, 33.7% of the follicular thyroid cancer cases presented with distant metastases during the follow-up period [7]. When comparing the clinical presentations of the follicular thyroid cancer with other series, a relatively high incidence of the distant metastases was noted [3,6,7]. Hematogenous spreading had been known as the main way of distant metastases in follicular thyroid carcinoma. T...

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“…According to Powari et al, [17] FVPTC should be considered in the diagnosis if the smears show high cellularity, syncytial clusters and follicular arrangement and thick colloid. Shih SR et al, [15] concluded in their study that it was difficult to differentiate FVPTC from classic PTC in FNAC and when follicular structures were seen in smears, careful search for nuclear features should be done.…”

Section: Discussionmentioning

confidence: 99%

Follicular Variant of Papillary Thyroid Carcinoma: Cytological Indicators of Diagnostic Value

Manimaran

Karthikeyan²,

Khan

et al. 2014

JCDR

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Fine needle aspiration cytology of follicular variant of papillary carcinoma of thyroid

Cited by 30 publications

References 5 publications

Cytological Diagnosis of Follicular Variant of Papillary Thyroid Carcinoma before and after the Bethesda System for Reporting Thyroid Cytopathology

Cytological Diagnosis of Follicular Variant of Papillary Thyroid Carcinoma before and after the Bethesda System for Reporting Thyroid Cytopathology

Follicular Thyroid Carcinomas with Lung Metastases: A 23-Year Retrospective Study

Follicular Variant of Papillary Thyroid Carcinoma: Cytological Indicators of Diagnostic Value

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