Fine‐needle aspiration cytology of neoplastic cysts of the pancreas

Jones, Edward C.; Suen, Kenneth C.; Grant, Dennis R.; Chan, Norman

doi:10.1002/dc.2840030313

Cited by 56 publications

(22 citation statements)

References 17 publications

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“…This was due to the presence of upper gastrointestinal tract contamination, a diagnostic pitfall that frequently occurs with EUS-guided FNA as the needle passes through the stomach or the duodenum. Retrospectively, findings were consistent with what had previously been described by Jones et al 31 The specimen was relatively acellular, with few sheets of cuboidal cells with pale to clear glycogen-containing cytoplasm. The nuclei were bland and centrally located and had inconspicuous nucleoli.…”

Section: Discussionsupporting

confidence: 78%

Fine Needle Aspiration Biopsy for Preoperative Workup of Pancreatic Cystic Neoplasms

Delatour¹,

Policarpio‐Nicolas²,

Yazdi³

et al. 2007

Acta Cytologica

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Section: Discussionsupporting

confidence: 78%

Fine Needle Aspiration Biopsy for Preoperative Workup of Pancreatic Cystic Neoplasms

Delatour¹,

Policarpio‐Nicolas²,

Yazdi³

et al. 2007

Acta Cytologica

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“…FNA of fluid within SCA microcysts can be challenging. When obtained, the fluid is usually thin, and cytological analysis reveals cuboidal glycogen-staining cells in 50% of cases (26)(27)(28). Given their benign nature, SCA should be resected only if symptomatic, or if the diagnosis remains in doubt.…”

Section: Serous Cystadenomamentioning

confidence: 99%

ACG Practice Guidelines for the Diagnosis and Management of Neoplastic Pancreatic Cysts

Khalid¹,

Brugge²

2007

Am J Gastroenterology

290

197

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The diagnosis and management of pancreatic cystic lesions is a common problem. At least 1% of hospitalized patients at major medical centers will have a pancreatic cystic lesion on cross sectional imaging. Up to a quarter of all pancreata examined in an autopsy series contained a pancreatic cyst, 16% of which were lined by an "atypical" epithelium and 3% of which had progressed to carcinoma-in-situ (high grade dysplasia). in the past, it was thought these cystic lesions were benign, but increasing evidence points to the cystic lesions as being the origin of some pancreatic malignancies.The most important clinical tools in the diagnosis and management of pancreatic cystic lesions are cross sectional imaging, endoscopic ultrasound, and cyst fluid analysis. The most important differential diagnosis is distinguishing mucinous (pre-malignant) and non-mucinous cystic lesions. The findings of a macrocystic lesion containing viscous fluid rich in CEA are supportive of a diagnosis of a mucinous lesion. Serous lesion are the most common non-mucinous cyst and are characterized by a microcystic morphology, non-viscous fluid and a low concentration of CEA in the cyst fluid.The following document includes a description of neoplastic pancreatic cysts, a critical review of relevant diagnostic tests, and a discussion of treatment options. We have proposed a set of guidelines for the diagnonis and management of patients with neoplastic pancreatic cysts. The guidelines are based on published data backed by an analysis of the quality of the data and are designed to address the most frequent and important clinical scenarios. In addition to providing a summary of the diagnostic data, we offer diagnostic and management suggestions based on 13 common clinical problems. Although the field is rapidly evolving, a set of core principles is provided based on a balance between the risk of malignancy and the benefit of pancreatic resection.

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“…This did not include reports of the use of FNA for the diagnosis that lack a description of the cytomorphologic features of the case(s). These reports are collected, reviewed and compared with the current findings [6,7,8,9,10,11,12,13,14,15,16,17,18,19,20,21]. …”

Section: Methodsmentioning

confidence: 99%

Serous Cystadenoma of the Pancreas with Endoscopic Ultrasound Fine Needle Aspiration Biopsy and Surgical Correlation

Collins

2013

Acta Cytologica

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Objectives: Endoscopic ultrasound (EUS) fine needle aspiration (FNA) biopsies are commonly used to diagnose tumors of the pancreas. Serous cystadenoma (SCA) is a benign neoplasm that is uncommon and accounts for 1-2% of all pancreatic neoplasms. Study Design: Surgically excised SCAs with preoperative EUS FNA biopsy over a 10-year span were identified. Clinical data were collected, and cytomorphologic features reviewed retrospectively and correlated with surgical excision data. Original cytopathologic diagnoses and retrospectively reviewed cytomorphology features were recorded. Results: Seventeen patients were identified. Original EUS FNA interpretation included 1 ‘unsatisfactory', 9 ‘negative for malignancy' and 7 ‘atypical' or greater; however, all cases were categorized as benign/negative or nondiagnostic on retrospective review. The cases were hypocellular and possessed variable (rare to few-moderate) groups of bland cuboidal epithelial cells embedded in granular debris. Mucosal sampling was present (7/17) and cell blocks were acellular (5/17). Conclusion: This is a large series of pancreas SCAs subjected exclusively to EUS FNA biopsy where all cases had surgical excision confirmation. The 17 cases had hypocellular aspirate smears with the majority showing few bland epithelial cells; however, this can limit definitive diagnosis based on the cytomorphologic evaluation alone. The aspirate smear pattern of EUS FNA of SCAs of the pancreas supports a benign/negative or nondiagnostic categorization.

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Fine‐needle aspiration cytology of neoplastic cysts of the pancreas

Cited by 56 publications

References 17 publications

Fine Needle Aspiration Biopsy for Preoperative Workup of Pancreatic Cystic Neoplasms

Fine Needle Aspiration Biopsy for Preoperative Workup of Pancreatic Cystic Neoplasms

ACG Practice Guidelines for the Diagnosis and Management of Neoplastic Pancreatic Cysts

Serous Cystadenoma of the Pancreas with Endoscopic Ultrasound Fine Needle Aspiration Biopsy and Surgical Correlation

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