Peripheral primitive neuroectodermal tumors
(PNET) are usually located in bone or soft tissue in
children or young adults but can also appear at a more
advanced age. Case Report: A 60-year-old woman was
admitted to our hospital presenting with a tumor of the
right breast. Imaging studies led to the diagnosis of suspected
benign lesion. Cytologic examination showed
atypical cells. The biopsy showed a tumor composed of
medium-sized tumor cells with round and ovoid vesicular
nuclei and ill-defined cellular margins. The growth
pattern was mainly solid in cell clusters. Focally sinusoidal,
blood-filled spaces were present. Cytogenetic examination
of 20 metaphases showed the karyotype
46,XX,t(11;22)(q24,q12)/46,XX. Mastectomy was performed,
and adjuvant chemotherapy and radiotherapy
were given. After a follow-up of 72 month, the patient is
alive without evidence of disease. Conclusion: The adjuvant
therapy (VACA regime) seems to lead, independently
from tumor localization and patient age, to longer disease-
free survival.