Fine Needle Aspiration Cytology of Eccrine Spiradenoma of Back: Report of a Rare Case

Sinha, Anuradha; Pal, Subrata; Phukan, Jyoti Prakash

doi:10.4103/0974-2727.141519

Cited by 13 publications

(16 citation statements)

References 7 publications

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“…[2345] Most of these have been reported in adult female patients, presenting with painful nodules, similar to the present case. On cytologic examination, presence of small hyaline bodies reminiscent of stromal matrix and basement membrane material within cohesive clusters of banal, round to oval cells, including relatively darker, myoepithelial cells and scattered lymphocytes constituted as diagnostic clues for a skin adnexal tumor, over ES, even though both tumors display round cells with rosette formations.…”

Section: Discussionsupporting

confidence: 82%

“…[123456] Rarely, cases of multiple eccrine spiradenomas have been reported. [7] The present case is the first report of multiple eccrine spiradenomas, identified as an “adnexal tumor” on FNAC smears.…”

Section: Discussionmentioning

confidence: 99%

“…On cytologic examination, presence of small hyaline bodies reminiscent of stromal matrix and basement membrane material within cohesive clusters of banal, round to oval cells, including relatively darker, myoepithelial cells and scattered lymphocytes constituted as diagnostic clues for a skin adnexal tumor, over ES, even though both tumors display round cells with rosette formations. [2345] In addition, ES comprises tumor cells with coarse nuclear chromatin. While diagnosis of an adnexal tumor can be made on FNAC smears, its subcategorization is difficult, in view of overlapping morphological features.…”

Section: Discussionmentioning

confidence: 99%

“…[1] However, there is limited literature on the FNAC of skin adnexal tumors, including eccrine spiradenomas. [23456]…”

Section: Introductionmentioning

confidence: 99%

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Cytopathologic features of an unusual case of multiple eccrine spiradenomas misdiagnosed as a malignant round cell tumor

Rekhi

Agarwal

2017

J Cytol

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A 28-year-old lady presented with multiple swellings in her left shoulder, associated with intermittent pain since last one and a half years. Radiologic imaging revealed multiple, well-defined, subcutaneous lesions in her left supraclavicular region. Fine needle aspiration cytology (FNAC) smears were initially reported as Ewing sarcoma, elsewhere. On review, the smears showed cohesive clusters of round-to-oval cells with scant cytoplasm, which were focally arranged in an acinar-rosetting pattern around hyaline “droplets/bodies,” along with few scattered lymphocytes against a background of red blood cells. The diagnosis considered was adnexal tumor. Subsequent biopsy from the multiple lesions confirmed the diagnosis of eccrine spiradenoma. By immunohistochemistry, tumor cells were positive for CK7, epithelial membrane antigen (focally), S100 protein, and tyrosine-protein kinase Kit(C-KIT) /Cluster of differentiation (CD117). This case underscores the value of FNAC in skin adnexal tumors and constitutes as the first case report of multiple eccrine spiradenomas, initially misdiagnosed as Ewing sarcoma. Literature review of similar reported cases with treatment implications are presented.

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Section: Discussionsupporting

confidence: 82%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

“…[1] However, there is limited literature on the FNAC of skin adnexal tumors, including eccrine spiradenomas. [23456]…”

Section: Introductionmentioning

confidence: 99%

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Cytopathologic features of an unusual case of multiple eccrine spiradenomas misdiagnosed as a malignant round cell tumor

Rekhi

Agarwal

2017

J Cytol

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“…9 Another differential diagnosis of cytological diagnosis of cylindroma is eccrine spiradenoma. 10 Cytology of eccrine spiradenoma contains epithelial, myoepithelial cells, and lymphocytes. The epithelial cells are arranged in a rosette like pattern but it lacks magenta coloured hyaline globules.…”

Section: Introductionmentioning

confidence: 99%

Fine needle aspiration cytology of cylindroma of scalp: A case report

Pal

Bose

Sikder

et al. 2016

Diagnostic Cytopathology

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Cylindromas are uncommon benign adnexal tumor. Multiple cylindromas are commonly genetically inherited and also known as "turban tumor." Cytology of dermal cylindroma is rarely discussed in previous literature. We have diagnosed a case of dermal cylindroma of scalp in an elderly female patient by fine needle aspiration cytology of the lesion and further confirmation was done by histopathology. Cytology consists of many clusters of small round to oval basaloid cells surrounded and attached with magenta coloured acellular hyaline material. The cells have very scanty cytoplasm and dark, round to oval hyperchromatic nuclei without any nuclear membrane irregularity. Histopathology revealed nests of tumor cells separated by dense pink, PAS positive basement membrane material with a jigsaw puzzle appearance. Cytology of cylindroma should be differentiated from adenoid cystic carcinoma and other benign adnexal tumor like spiradenoma. We have discussed the case of cylindroma of scalp diagnosed by cytology and confirmed by histopathology. Diagn. Cytopathol. 2016;44:1082-1084. © 2016 Wiley Periodicals, Inc.

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Ψ Multiple eccrine spiradenomas with a zosteriform pattern—Report of a rare case diagnosed on fine needle aspiration cytology

Agnihotri

Kothari

Naik

2017

Diagnostic Cytopathology

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FNAC, eccrine spiradenoma, multipleEccrine spiradenoma (ES) is an uncommon benign adnexal neoplasm arising from intra-dermal part of the duct of eccrine gland. 1 The committed sites are trunk, extremities and head and neck. 1 It usually presents as a tender dermal solitary nodule and rarely as multifocal with a linear zosteriform or blaschkoid distribution. 2 There are a few isolated references of multiple ES diagnosed on histopathology and only a single documented case on cytology. This case of multiple ES with a zosteriform pattern; diagnosed on fine needle aspiration cytology (FNAC) is reported for its rarity and classical clinical as well as cytological features.A 35-year-old woman presented with painful, gradually increasing swellings on the right lower extremity since approximately ten years. FIG URE 1 A: Clinical picture: Multiple, discrete, well-circumscribed, subcutaneous nodules with bluish hue, in a linear dermatomal distribution over the calf region. B: Cohesive clusters of basaloid cells with interspersed metachromatic hyaline bodies (Giemsa stain, 1003). C: Acinar arrangement of tumor cells around spherical hyaline droplet and scattered spindle cells resembling myoepithelial cells (Giemsa stain, 4003). D: Triad of epithelial-myoepithelial-lymphocytic cells. Basaloid cells showing round nuclei with inconspicuous nucleoli and scant cytoplasm. (Papanicolaou stain, 4003). E: Cluster of matured lymphocytes (Giemsa stain, 4003) She gave a history of excision of similar lesions in the past, details of which were however not available. The patient was concerned that the lesions had increased in number and size lately.Physical examination revealed multiple, discrete, well-circumscribed, subcutaneous nodules in a linear dermatomal distribution over the right calf region ( Figure 1A). The nodules ranged from 0.5 to 2 cm in size and were firm, tender and fixed to the skin. Few lesions also showed slight bluish hue of the overlying skin. Clinical impression was multiple lipofibromas. FNAC was performed from multiple nodules. Papanicolaou and Giemsa stained smears were prepared which were moderately cellular, comprising of cells in cohesive clusters, sheets, and acinar pattern ( Figure 1B). At places, cells were arranged around metachromatic/magenta spherical hyaline bodies ( Figure 1C). The cells were basaloid with scant cytoplasm, round to oval nuclei and inconspicuous nucleoli ( Figure 1D).Background showed scattered spindle cells with darker nuclei resembling

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Fine Needle Aspiration Cytology of Eccrine Spiradenoma of Back: Report of a Rare Case

Cited by 13 publications

References 7 publications

Cytopathologic features of an unusual case of multiple eccrine spiradenomas misdiagnosed as a malignant round cell tumor

Cytopathologic features of an unusual case of multiple eccrine spiradenomas misdiagnosed as a malignant round cell tumor

Fine needle aspiration cytology of cylindroma of scalp: A case report

Ψ Multiple eccrine spiradenomas with a zosteriform pattern—Report of a rare case diagnosed on fine needle aspiration cytology

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