Fine-needle aspiration cytology of Kikuchi Fujimoto disease

Hasan, Mehboob; Zaheer, Sufian; Sofi, Lateef Ahmed; Parvez, Anjum

doi:10.4103/0970-9371.54870

Cited by 4 publications

(1 citation statement)

References 5 publications

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“…However, Hasan et al . reported that, with clear symptoms and characteristic features of KFD in FNAC results, the diagnosis of KFD may be established without lymphadenectomy [ 12 ]. Yu et al .…”

Section: Discussionmentioning

confidence: 99%

A white man with Kikuchi-Fujimoto disease mimicking lymphoma, preceded by frequent episodes of tonsillitis: a case report

et al. 2017

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BackgroundKikuchi-Fujimoto disease is a very rare cause of benign lymphadenopathy affecting mainly young Asiatic females. Little is known about the causative agent of Kikuchi-Fujimoto disease; however, there are hypotheses of infectious, autoimmune, or hyperimmune background of the disease that have not yet been confirmed in the conducted studies. Frequent episodes of tonsillitis preceding the onset of Kikuchi-Fujimoto disease have not been described as yet.Case presentationA 23-year-old white man with a history of over 20 episodes of tonsillitis in the preceding 2 years was admitted to our hospital because of cervical unilateral lymphadenopathy, fever, night sweating, weight loss, and fatigue. On admission, slight tenderness of cervical lymph nodes and asymmetric palate tonsil enlargement were noted. Owing to the patient’s general symptoms and history of malignancy in his close family, a malignant disease such as lymphoma was suspected. Histopathological examination of the excised lymph node revealed areas of coagulative necrosis with abundant karyorrhectic debris, with histiocytes and lymphocytes observed at the margins of the necrotic areas. The microscopic examination led to an unexpected diagnosis of Kikuchi-Fujimoto disease. The patient was treated symptomatically. All of the patient’s symptoms, excluding tonsil enlargement, retreated within 2 months.ConclusionsIn the differential diagnosis of cervical lymphadenopathy in patients with frequent episodes of tonsillitis, Kikuchi-Fujimoto disease should be taken into account. Kikuchi-Fujimoto disease may convincingly mimic symptoms characteristic of lymphoma.

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Section: Discussionmentioning

confidence: 99%

A white man with Kikuchi-Fujimoto disease mimicking lymphoma, preceded by frequent episodes of tonsillitis: a case report

et al. 2017

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Diagnosing Kikuchi's disease on fine needle aspiration biopsy

2019

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ObjectiveTo investigate the diagnostic utility of fine needle aspiration (FNA) smear, cell block (CB), flow cytometry (FC) and tuberculosis polymerase chain reaction (Tb‐PCR) analysis for Kikuchi's disease (KD).MethodsA total of 173 FNA biopsy samples were collected using a Youyi aspirator. KD was diagnosed by FNA smear, with or without, CB, FC and Tb‐PCR.ResultsOut of 173 patients, 131 (75.7%) were female and 126 (72.8%) aged 21‐40 years. Of these, 171 patients (98.8%) presented with painful enlarged cervical lymph nodes. All cytological samples identified intracellular apoptotic debris embedded in the cytoplasm of crescentic and phagocytic macrophages. In 24 cell‐blocks (CBs), clusters of CD123 positive plasmacytoid monocytes were observed in KD. FC and CBs showed non‐specific lymphoid hyperplasia in nine cases with suspicious lymphoma. Tb‐PCR was negative in five cases with suspicion of tuberculosis.ConclusionsIn summary, FNA biopsy is a fast, reliable, and relatively inexpensive diagnosis tool for KD. CB preparation is an important adjunct method for the diagnosis of KD.

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Kikuchi-Fujimoto disease on aspiration cytology: diagnostic dilemma and clinicopathologial correlation – A retrospective study in a tertiary care hospital

Dixit¹,

S²,

P³

et al. 2019

ACHR

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Kikuchi -Fujimoto disease (KFD), also known as Histiocytic necrotizing lymphadenitis is a benign, uncommon, self-limited disease of unknown etiology. Young females are primarily affected and it manifests primarily as cervical lymphadenopathy with tenderness at times. Kikuchi and Fujimoto, way back in 1972, reported it from Japan, independently and simultaneously, as a type of lymphadenitis associated with numerous histiocytes and extensive nuclear debris. The present study aims to study the key cytomorphological features of KFD along with its clinicopathological correlation. Materials and Methods: This present study was carried out in a tertiary care hospital for a period of one year. The cases that were diagnosed as KFD on Fine needle aspiration cytology (FNAC) and whose follow up histopathology was confirmatory were included in the present study. Papanicolaou stain (PAP stain), Hematoxylin and eosin stain (H&E), and May-Grunwald Giemsa stain (MGG stain) was done on smears. Following cytological features were evaluated; cellularity, crescentic histiocytes, plasmocytoid monocytes, karyorrhectic debris and intra and extra cytoplasm apoptotic bodies. Result: Females in the age group of 31-40 years were most commonly affected with cervical lymphadenopathy as the presenting feature. The most common clinical diagnosis rendered by clinicians was tuberculosis. Karyorrhexis, crescentic histiocytes and plasmacytoid monocytes were the key cytological features. Conclusion:This study emphasizes on the key cytological features of the rare entity of KFD and its clinicopathological correlation. Knowledge and timely diagnosis of this rare entity avoids unnecessary surgical intervention and helps in timely management.

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Fine-needle aspiration cytology of Kikuchi Fujimoto disease

Cited by 4 publications

References 5 publications

A white man with Kikuchi-Fujimoto disease mimicking lymphoma, preceded by frequent episodes of tonsillitis: a case report

A white man with Kikuchi-Fujimoto disease mimicking lymphoma, preceded by frequent episodes of tonsillitis: a case report

Diagnosing Kikuchi's disease on fine needle aspiration biopsy

Kikuchi-Fujimoto disease on aspiration cytology: diagnostic dilemma and clinicopathologial correlation – A retrospective study in a tertiary care hospital

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