Fine needle aspiration cytology of a granular cell tumour of the oesophagus

Prematilleke, I.; Piris, J; Shah, Ketan

doi:10.1111/j.1365-2303.2004.00126.x

Cited by 5 publications

(4 citation statements)

References 4 publications

(7 reference statements)

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“…EUS‐guided tissue acquisition is an accepted method for tissue diagnosis of GI subepithelial tumors. EUS‐guided FNA has been advocated for the diagnosis of GCT in one case report 14 . Both EUS FNA procedures in the current series were nondiagnostic.…”

Section: Discussionmentioning

confidence: 63%

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Endoscopic diagnosis and resection of esophageal granular cell tumors

Zhong

Katzka

Smyrk

et al. 2011

Diseases of the Esophagus

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Granular cell tumors (GCT) are uncommon neoplasms. There is controversy regarding the endoscopic diagnosis and treatment of esophageal GCT. We studied the endoscopic diagnosis and management of esophageal GCT among 23 patients identified in a single-institution pathology database. Medical records, pathology, and endoscopic images were reviewed. All patients underwent endoscopy and endoscopic ultrasonography (EUS), and endoscopic resection was performed in 10 patients. Seven of 23 patients had more than one esophageal GCT. Only six lesions exhibited a classic yellow discoloration. Among patients with a single GCT, three, four, and nine lesions were located in the proximal, middle, and distal esophagus, respectively. EUS showed hypoechoic, smooth-edged lesions usually confined to deep mucosa and submucosa. Standard forceps biopsy was diagnostic in 19 of 23 patients (83%). Ten GCT ≤ 10 mm in diameter underwent successful endoscopic mucosal resection without complication. The endoscopic appearance, location, and number of esophageal GCT are highly variable. Histological proof is still necessary for the differential diagnosis of this rare neoplasm. Endoscopic forceps biopsy is usually diagnostic. Endoscopic resection appears safe and effective in selected cases with lesions ≤ 10 mm.

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Section: Discussionmentioning

confidence: 63%

“…Several previous case reports including one case series describe the safety and efficacy of endoscopic resection 7–13 . One series describes the EUS characteristics of GCT, but only one case report has addressed the utility of EUS‐guided aspiration or biopsy for diagnosis 14 …”

Section: Introductionmentioning

confidence: 99%

Endoscopic diagnosis and resection of esophageal granular cell tumors

Zhong

Katzka

Smyrk

et al. 2011

Diseases of the Esophagus

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“…The cytologic findings of granular cell tumors have been previously described in organs such as esophagus, breast, tongue, bronchus, and skin [13-15]. Typically smears are composed of large round or polygonal cells with indistinct cytoplasmic borders, abundant PAS positive and S-100 positive cytoplasmic granules, and small round dark eccentric nuclei.…”

Section: Discussionmentioning

confidence: 98%

Preoperative diagnosis of a mediastinal granular cell tumor by EUS-FNA : A case report and review of the literature

et al. 2005

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We report the first case of a posterior mediastinal granular cell tumor initially diagnosed on cytologic material obtained via endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) in a 51-year-old male with a prior history of colon cancer. Aspirates obtained were cellular and composed of polygonal cells with abundant granular cytoplasm and small, round dark nuclei. An immunoperoxidase stain performed on the cell block for antibodies to S-100 protein showed strong, diffuse staining of the cytoplasmic granules. Electron microscopy performed on the cell block revealed numerous cytoplasmic lysosomes. This is the first case report in the English literature of a definitive preoperative diagnosis of a mediastinal granular cell tumor utilizing material obtained via EUS-FNA.

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“…Lesions >4 cm increase the risk to around 2-4% [2]. Cytologic or histopathologic evaluation staining for S-100 can be helpful in differentiating this tumor [75]. For asymptomatic GCTs that are not excised, surveillance with EUS every 1-2 years is recommended to monitor changes in size.…”

Section: Lipomamentioning

confidence: 99%

Role of Endoscopic Ultrasound in Subepithelial Lesions (SELs)

Al-Lehibi¹,

Bamakhrama²

2017

Endoscopic Ultrasound - From Usual to Special

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A subepithelial lesion (SET) is defined as a lesion, bulge or impression visible within the lumen of the gastrointestinal tract that is covered by normally appearing mucosa and usually found incidentally during routine endoscopy. Such a lesion could be either an intramural mass or an impression caused by extramural structures. The old terminology has recently been replaced by the term "subepithelial lesion" because intramural lesions may arise and can be located in any layer of the GI wall underneath the epithelium. The most common SELs are gastrointestinal stromal tumors (GISTs), leiomyomas, lipomas, granular cell tumors (GCTs), pancreatic rests and carcinoid tumors. The prognosis varies from benign to potentially malignant. While the majority of the lesions are considered benign, some tumors such as GISTs and carcinoids have a strong propensity for malignant transformation. Endoscopic ultrasonography (EUS) is the most accurate diagnostic method for distinguishing between extraluminal compressions and intramural lesions and plays a critical role in the detection and management of SELs. This is because EUS can reveal the precise sonographic nature of the lesion even though sometimes there are complex cases, which are difficult to diagnose by EUS alone. Performing routine biopsies and obtaining tissue samples for diagnosis can be difficult because SELs are located beneath the normal epithelial layer. Mostly, EUS allows the practitioner to extract an optimal tissue sample since it allows fine-needle aspiration (FNA) and fine-needle biopsy (FNB) both of which provide good results. With immunocytochemical staining, all these techniques increase the accuracy of the diagnosis. Evaluation of subepithelial lesions by means of EUS imaging will provide further characterization of the lesion to help guide us in appropriate differential diagnosis and further management. In this chapter, we provide a systematic EUS-guided approach to the diagnosis, management and later surveillance for SELs, as well as presenting updated diagnostic techniques that may help physicians to appropriately manage these subepithelial lesions.

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Fine needle aspiration cytology of a granular cell tumour of the oesophagus

Cited by 5 publications

References 4 publications

Endoscopic diagnosis and resection of esophageal granular cell tumors

Endoscopic diagnosis and resection of esophageal granular cell tumors

Preoperative diagnosis of a mediastinal granular cell tumor by EUS-FNA : A case report and review of the literature

Role of Endoscopic Ultrasound in Subepithelial Lesions (SELs)

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