Fine Needle Aspiration Cytology of Sclerosing Lobular Hyperplasia of the Breast

Jain, Megha; Arora, Vinod; Singh, Navjeevan; Bhatia, Arati

doi:10.1159/000328301

Cited by 9 publications

(10 citation statements)

References 4 publications

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“…In a previous report, fineneedle aspiration cytology of the SLH was not conclusive [4]. An experienced cytologist may differentiate it from other benign epithelial tumor by the cytologic features [8]. In our report, all cases were confirmed by surgical biopsy.…”

Section: Discussioncontrasting

confidence: 41%

Sclerosing lobular hyperplasia: sonographic pathologic correlation

Cho

Park

et al. 2002

Eur Radiol

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The objective was to evaluate the sonographic findings of sclerosing lobular hyperplasia (SLH) of the breast and to correlate the sonographic findings and the pathologic features. This study consisted of 9 patients with pathologically proven sclerosing lobular hyperplasia who had undergone a preoperative imaging study. We retrospectively reviewed 9 ultrasonograms and 6 mammograms. In each patient mammographic findings including, shape and margin, and ultrasonographic findings including the size, length-to-anteroposterior ratio, shape, margin, internal echo pattern, and the presence and location of internal echogenic septum, were evaluated. Histopathologic correlations focused on characteristic imaging findings. Of the 6 mammograms, 4 cases showed a lobular (3 of 6) or an oval shaped mass (1 of 6) with a partly obscured margin (4 of 6). The remaining 2 cases showed heterogeneously dense breast without visible mass. Ultrasonograms showed a lobular (5 of 9) or an oval (4 of 9) shaped mass with a circumscribed margin (9 of 9). The mean length/anteroposterior ratio was 1.98. Intratumoral echogenic septum was present in 8 cases. Six cases had a peripherally arising septum. Histopathologic review revealed that this septum was correlated to interlobular sclerosis. A peripherally arising intratumoral echogenic septum on ultrasonography seen in SLH might be explained by the interlobular sclerosis.

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Section: Discussioncontrasting

confidence: 41%

Sclerosing lobular hyperplasia: sonographic pathologic correlation

Cho

Park

et al. 2002

Eur Radiol

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“…Fibroadenomas are benign neoplasms that constitute 50-76% of breast masses in children and adolescents [2,5,7,[12][13][14][15][16]. Fibroadenomas have high cellularity and a biphasic pattern consisting of epithelial and stromal components.…”

Section: Discussionmentioning

confidence: 99%

“…Sclerosing lobular hyperplasia is a benign tumor that resembles fibroadenoma clinically and is found up to the age of 35 years. These tumors have not been found to have malignant potential [15]. Fibroadenoma is three times as common as sclerosing lobular hyperplasia [15].…”

Section: Discussionmentioning

confidence: 99%

Role of Breast Sonography in Imaging of Adolescents with Palpable Solid Breast Masses

Vade

Lafita²,

Ward³

et al. 2008

American Journal of Roentgenology

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Sonography was not useful for predicting the histologic diagnosis of all solid benign breast masses in adolescent patients. The Stavros sonographic criteria, however, were useful for predicting benignity in 65% of the breast masses on which histopathologic examination was performed. Tissue biopsy may be performed on solid breast masses that do not meet the criteria for benign masses according to the Stavros sonographic criteria.

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“…9 In all of them almost all of the NN showed strong p63 immunoreactivity. 9 NN are an important criterion in the diagnosis of fibroadenoma, 1,2,3 Phyllodes tumor, 11,12 fibrocystic mastopathy, 1 pseudoangiomatous stromal hyperplasia, 13 sclerosing lobular hyperplasia, 14 benign papillary lesions, 1,15 papillary adenoma of the nipple, 15 gynecomastia, 16 and other benign diseases. Occasionally, they may also be observed in aspirates from breast carcinomas.…”

Section: Discussionmentioning

confidence: 99%

Naked nuclei revisited: p63 Immunoexpression

Reis‐Filho

Albergaria

Milanezi

et al. 2002

Diagnostic Cytopathology

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The presence of naked nuclei (NN) in cytological preparations of fibroadenomas is a well-known finding. Regardless of their importance on the differential diagnosis of fibroadenoma and other benign lesions of the breast, the origin of NN remains elusive. Despite previous efforts to characterize them, the lack of a reliable nuclear marker for myoepithelial cells impaired definitive conclusions. We performed a systematic evaluation of p63 expression in cytological and histological preparations of 10 fibroadenoma specimens. We observed that in histological sections, p63 was restricted to the nuclei of myoepithelial/basal cells in lobules and ducts of normal breast. In fibroadenomas, p63 decorated the nuclei of myoepithelial cells in the periphery of epithelial duct-like formations and slit-like formations. No p63 immunoreactivity was observed in stromal or epithelial cells. In cytological samples, almost all NN and cells surrounding epithelial cell clusters were stained; no stromal cell admixed with fibrillary matrix or epithelial cell was stained with p63. Based on our findings, we strongly suggest that most, if not all, NN are myoepithelial in origin.

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Fine Needle Aspiration Cytology of Sclerosing Lobular Hyperplasia of the Breast

Cited by 9 publications

References 4 publications

Sclerosing lobular hyperplasia: sonographic pathologic correlation

Sclerosing lobular hyperplasia: sonographic pathologic correlation

Role of Breast Sonography in Imaging of Adolescents with Palpable Solid Breast Masses

Naked nuclei revisited: p63 Immunoexpression

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