Fine Needle Aspiration Cytology of Papillary Endothelial Hyperplasia

Novak, Joseph A.; Ferguson, David; Komorowski, Richard

doi:10.1159/000331163

Cited by 14 publications

(35 citation statements)

References 5 publications

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“…The published cytologic literature describes a varied morphology leading to frequent misdiagnoses [3,4,5,6,7,8]. The case reported by García-Macías et al [4] was cytologically diagnosed as vascular mesenchymal tumor of suspected malignancy because of the polymorphic (two type) population of cells, prominent nucleoli, and occasional mitotic figures.…”

Section: Discussionmentioning

confidence: 99%

“…A 63-year-old man having an intraorbital mass with nerve symptomatology was misdiagnosed as having SCC because of cellular atypia and a past history of SCC [7]. Also, in the case reported by Novak et al [3], papillary endothelial hyperplasia arising in a hematoma was misdiagnosed as metastatic SCC because of moderate cellularity and cellular atypia. In a recent report, FNA from a palate swelling was misdiagnosed as adenoid cystic carcinoma because of the presence of small round hyperchromatic cells surrounding hyaline cores [8].…”

Section: Discussionmentioning

confidence: 99%

“…It presents clinically as a small, firm, superficial mass most commonly in veins of the head and neck or limbs. Fine-needle aspiration (FNA) findings of this lesion have been described as isolated case reports in the literature [3,4,5,6,7,8]. In the majority of cases a definite diagnosis of IPEH could not be made cytologically.…”

Section: Novel Insightsmentioning

confidence: 99%

“…In the majority of cases a definite diagnosis of IPEH could not be made cytologically. This lesion has been variously misdiagnosed as malignant vascular tumor [4], squamous cell carcinoma (SCC) [3,7], metastatic embryonal carcinoma [6], and adenoid cystic carcinoma [8]. …”

Section: Novel Insightsmentioning

confidence: 99%

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Cytologic Diagnosis of Intravascular Papillary Endothelial Hyperplasia: A Report of Two Cases and Review of Cytologic Literature

Handa¹,

Khurana²,

Singhal³

et al. 2012

Acta Cytologica

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Background: Intravascular papillary endothelial hyperplasia (IPEH), previously known as ‘Masson’s hemangioma’, is a reactive endothelial proliferation that occurs most commonly in the vessels of the head, neck, and extremities. The cytologic findings of the lesion are varied and depend on the age of the lesion. Cases: Case 1 is a 61-year-old man who presented with a swelling on the medial aspect of the forearm. The clinical diagnosis was lipoma. Cytologic smears showed spindle cells tagging onto a rich capillary network and smaller round cells arranged around hyaline cores. The cytologic diagnosis was benign vascular tumor. On histolopathogic examination a diagnosis of IPEH was given. Case 2 is a 45-year-old man who presented with swelling on the dorsal aspect of the wrist. The cytologic diagnosis of giant cell tumor was made based on the presence of scattered spindled cells and multinucleate giant cells. The giant cells had various shapes like round or crescent and had 10–25 nuclei. The lesion was excised and a diagnosis of IPEH was rendered. Conclusion: These two cases highlight the varied cytomorphology of IPEH making the pinpoint diagnosis of this lesion difficult on cytologic smears.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Novel Insightsmentioning

confidence: 99%

Section: Novel Insightsmentioning

confidence: 99%

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Cytologic Diagnosis of Intravascular Papillary Endothelial Hyperplasia: A Report of Two Cases and Review of Cytologic Literature

Handa¹,

Khurana²,

Singhal³

et al. 2012

Acta Cytologica

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“…Histopathological examination in the first patient revealed not only an organized hemorrhage with granulation tissue and newly formed bone trabeculae but also foci of papillary endothelial hyperplasia as in organized thrombosis [12]. The difference between our cases and those reported previously is not only the age of the children but also the extent of the lysis of the calvarial bone.…”

Section: Discussionmentioning

confidence: 53%

Progressive Osteolytic Calvarial Lesions in Children after Minor Head Injury

Hermann¹,

Hong²,

Brandis

et al. 2011

Pediatr Neurosurg

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Objective: Osteolytic lesions of the skull in children have a broad differential diagnosis including congenital, inflammatory and neoplastic lesions. Progressive osteolysis of the skull secondary to head trauma is rare and has been poorly characterized. Methods: The pediatric database at our hospital was screened for children with osteolytic lesions who had a previous mild head injury without fracture or dural tears. We identified 2 children with circumscribed progressive cranial osteolysis after minor head trauma detected by CT and MRI scans. Three additional cases were found in a review of the published literature. Results: Ten children with an osteolytic skull lesion treated between January 1998 and February 2008 were identified in our pediatric database. In 2 children there was evidence of previous mild head injury without a skull fracture. Trauma had occurred 7 and 2 months prior to presentation, respectively. The inner table of the skull was intact in both cases. In 1 case, surgery was performed, and in the other case, a wait-and-see strategy was adopted. Pathological examination in case 1 revealed an organized hemorrhage with focal papillary endothelial hyperplasia. Conclusions: Progressive osteolytic calvarial lesions may occur in both infants and adolescents after mild head injury. They involve either only the diploe and outer table of the skull or both the inner and outer tables. These lesions might be due to intradiploic or subgaleal hematomas triggering an inflammatory process. While surgical resection can be considered to confirm a histopathological diagnosis and to exclude other diagnoses, spontaneous reossification is possible.

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Intravascular papillary endothelial hyperplasia of the neck masquerading as malignancy on fine‐needle aspiration cytology

Suh¹,

Shin²,

Park³

2003

Diagnostic Cytopathology

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Papillary endothelial hyperplasia (PEH) is an exuberant, usually intravascular endothelial proliferation that, in many respects, mimics angiosarcoma. A case of PEH originally suggestive of embryonal carcinoma by fine-needle aspiration is presented. A 12-year-old boy presented with a palpable mass on the right side of the neck. The mass was subsequently aspirated. Cytopathologic features showed cohesive sheets of polygonal pleomorphic cells with vesicular nuclei and prominent multiple nucleoli in a hemorrhagic background. Cytologic findings were strongly suggestive of metastatic embryonal carcinoma. There was no evidence of a primary lesion. After the mass was surgically excised, the pathologic findings showed PEH. A retrospective immunocytochemical stain for factor VIII-related antigen on a destained ethanol-fixed smear confirmed the endothelial nature of the polygonal cells. A vascular lesion should be considered, especially when atypical polygonal cells in a hemorrhagic background are present, as they were in this case.

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Fine Needle Aspiration Cytology of Papillary Endothelial Hyperplasia

Cited by 14 publications

References 5 publications

Cytologic Diagnosis of Intravascular Papillary Endothelial Hyperplasia: A Report of Two Cases and Review of Cytologic Literature

Cytologic Diagnosis of Intravascular Papillary Endothelial Hyperplasia: A Report of Two Cases and Review of Cytologic Literature

Progressive Osteolytic Calvarial Lesions in Children after Minor Head Injury

Intravascular papillary endothelial hyperplasia of the neck masquerading as malignancy on fine‐needle aspiration cytology

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