Fine needle aspiration cytology of bone tumours--the experience from the National Orthopaedic and Lagos University Teaching Hospitals, Lagos, Nigeria

Abstract

BackgroundDue to difficulty in confirming clinical suspicions of malignancy in patients presenting with bone tumours, the cost of surgical biopsies where hospital charges are borne almost entirely by patients, competition with bone setters and healing homes with high rate of loss to follow up; we set out to find if sufficient material could be obtained to arrive at reliable tissue diagnosis in patients with clinical and radiological evidence of bone tumours in our hospitals.MethodsAfter initial clinical and plain radiographic examinations, patients were sent for fine needle aspirations. Aspirations were carried out with size 23G needles of varying lengths with 10 ml syringes in a syringe holder (CAMECO, Sebre Medical, Vellinge, Sweden). The aspirates were air dried, stained by the MGG method and examined microscopically. Histology was performed on patients who had subsequent surgical biopsy. These were then correlated with the cytology reports.ResultsOut of 96 patients evaluated, [57 males, 39 females, Mean age 31.52 years, Age Range 4–76 years,] material sufficient for diagnosis was obtained in 90 patients. Cytological diagnosis of benign lesions was made in 40 patients and malignant in 47. Of these, 27 were metastases, osteogenic sarcoma 16, giant cell tumour 19, infection 11. Histology was obtained in 41 patients. Correct diagnosis of benignity was made in 17 out of 18 cases, malignancy in 21 out of 22 cases. One non-diagnostic case was malignant. The accuracy of specific cytological diagnosis was 36/41 (87.8%) and incorrect in 5/41 (12.2%).ConclusionWe conclude that FNAC can be useful in the pre-operative assessment of bone tumours especially where other diagnostic modalities are unavailable.

A Correlative Study of Fnac and Radiological Imaging of Bony Lesion In the Tertiary Health Centre Rims, Ranchi, Jharkhand: A Prospective Study

“…Accuracy of FNAC to diagnose true benign and malignant neoplastic lesion was found to be 84%. sensitivity and positive predictive value found to be 80% and 86.9% respectively which are (10) more than the study done by Ramana S.V et al , but lesser (9) than other studies like Obiageli E Nnodu O E et al and Jain (11) Vet al .…”

Imprint cytology of osteosarcoma of the jaw: a case report

“…The cytological exam permitted the diagnosis of a malignant mesenchymal tumor highly suggestive of osteosarcoma within a short period of time and even before the biopsy result. In addition, the imprint method permitted the collection of cells of excellent quality for analysis and more refined visualization of cellular aspects than in biopsy material, considering that the cells suffer modifications during the process of decalcification of the material [ 11 - 14 ].…”

Accuracy of plain radiographs in diagnosing biopsy-proven malignant bone lesions

“…Previous studies that have examined pre-biopsy imaging demonstrated a poor positive predictive value for malignancy (50% – 75%). 17,18,19,20,21,22,23 On the contrary, other studies have shown higher sensitivities and specificities when including MRI and computer-aided detection. 24,25,26,27 Given the paucity of literature on this topic locally, this study was implemented to test a radiologist’s interpretation of plain radiographs against a histopathological diagnosis.…”