Fine needle aspiration cytology of lung lesions: a clinicopathological and cytopathological review of 150 cases with emphasis on the relation between the number of passes and the incidence of pneumothorax

Halloush, Ruba A; Khasawneh, Faisal A; Saleh, Husain; Soubani, Ayman O.; Piskorowski, Thomas; Al‐Abbadi, Mousa A.

doi:10.1111/j.1365-2303.2007.00410.x

Cited by 25 publications

(23 citation statements)

References 31 publications

(77 reference statements)

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“…An experienced team can minimize the number of passages needed 33,34 and, in our series, satisfactory material was usually obtained at the first pass (243 out of 311). Other authors took two to five aspirates, which meant a higher pneumothorax rate; 35,36 the rate could be minimized by limiting the procedure to a single aspirate, 16 although Halloush recently found no association between the number of passes and its occurrence 37 . Tan et al.…”

Section: Discussionmentioning

confidence: 99%

“…Other authors took two to five aspirates, which meant a higher pneumothorax rate; 35,36 the rate could be minimized by limiting the procedure to a single aspirate, 16 although Halloush recently found no association between the number of passes and its occurrence. 37 Tan et al observed that pneumothorax risk could be reduced by avoiding pulmonary fissures and multiple punctures. 6 Our results are in agreement with Tan et al and Stewart and Stewart, 16 who found 29% rate of pnuemothorax in the third pass, as opposed to less than 1% in the first and second passes.…”

Section: Discussionmentioning

confidence: 99%

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Role and accuracy of rapid on‐site evaluation of CT‐guided fine needle aspiration cytology of lung nodules

et al. 2010

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Role and accuracy of rapid on‐site evaluation of CT‐guided fine needle aspiration cytology of lung nodules

et al. 2010

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“…[1][2][3] The FNA method became particularly attractive for the diagnosis of deep-seated tumor masses that otherwise would have required open procedures to obtain biopsy material. [1][2][3] In particular, because of patient safety considerations, FNA has continued to be an important method for obtaining a diagnosis in masses that involve the lung [4][5][6][7] and pancreas. [8][9][10][11][12][13] For pulmonary neoplasms, such as nonsmall cell carcinoma (NSCLC) and small cell undifferentiated carcinoma (SCLC), the risk of causing a significant pneumothorax when an incisional or larger bore, rigid-needle biopsy has favored the use of the safer FNA technique.…”

Section: Introductionmentioning

confidence: 99%

Clinical next‐generation sequencing successfully applied to fine‐needle aspirations of pulmonary and pancreatic neoplasms

Young

Wang²,

He³

et al. 2013

Cancer Cytopathology

114

116

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BACKGROUND: Next-generation sequencing was performed on pulmonary and pancreatic fine-needle aspirations (FNAs) and on paired FNAs and resected primary tumors from the same patient. METHODS: DNA was isolated in formalin-fixed, paraffin-embedded cell blocks from 16 pulmonary FNAs, 23 pancreatic FNAs, and 5 resected pancreatic primary tumors.Next-generation sequencing was performed for 4561 exons of 287 cancer-related genes and for 47 introns of 19 genes on indexed, adaptor-ligated, hybridization-captured libraries using a proprietary sequencing system (the Illumina HiSeq 2000). RESULTS: Genomic profiles were generated successfully from 16 of 16 (100%) pulmonary FNAs, which included 14 nonsmall cell lung cancers (NSCLCs) and 2 small cell lung cancers (SCLCs). The NSCLC group included 6 adenocarcinomas, 5 squamous cell carcinomas, and 3 NSCLCs not otherwise specified. Genomic profiles were successfully obtained from 23 of 23 (100%) pancreatic FNAs and from 5 of 5 (100%) matched pancreatic primary tumors, which included 17 ductal adenocarcinomas, 3 mucinous adenocarcinomas, 2 adenocarcinomas NOS, and 1 neuroendocrine tumor. Eightyone genomic alterations were identified in the 16 pulmonary FNAs (average, 5.1 genomic alterations per patient); and the most common genomic alterations were TP53, RB1, SOX2, PIK3CA, and KRAS. Eighty-seven genomic alterations were identified in the 23 pancreatic tumor FNAs (average, 3.8 genomic alterations per patient); and the most common genomic alterations were KRAS, TP53, CDKN2A/B, SMAD4, and PTEN. Among the pancreatic tumors, there was 100% concordance of 20 genomic alterations that were identified in 5 patient-matched FNA and surgical primary tumor pairs. CONCLUSIONS:The authors were able to perform next-generation sequencing reliably on FNAs of pulmonary and pancreatic tumors, and the genomic alterations discovered correlated well with those identified in matched resected pancreatic tumors. Cancer (Cancer Cytopathol) 2013;121:688-94.

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“…Among the possible complications, pneumothorax is by far the most frequent; its reported rate ranges widely from 22% to 45% (48)(49)(50). Cox et al demonstrated, with a study about the variables that affected the risk of pneumothorax during FNAB, how the only variables that have proved to be statistically significant were the dimensions of the nodules and the evidence of emphysema (51).…”

Section: Discussionmentioning

confidence: 99%

CT-guided fine-needle aspiration biopsy of solitary pulmonary nodules under 15 mm in diameter: time for an afterthought?

Tosi¹,

Mendogni²,

Palleschi³

et al. 2019

J. Thorac. Dis

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Background: Many studies on fine-needle aspiration biopsy (FNAB) for undetermined pulmonary nodules reported that diagnostic accuracy tended to decline, whereas complication prevalence raised as the size of nodule decreased. Reconsideration on the effectiveness of FNAB would be appropriate considering the dramatic increase in the identification of small nodules with screening programs and new demands of target therapies. The aim of this study was to verify the efficacy of FNAB in pulmonary nodules smaller than 15 mm. Methods: A retrospective, cohort study was conducted on patients with undetermined solitary pulmonary nodules (SPNs) who underwent computer tomography (CT) guided FNAB at our Institution from January 2012 to December 2014. Patients with SPNs with diameter up to 15 mm were considered; inclusion criteria comprised ASA 3, FEV1 <70% of predicted, cardiac comorbidity or previous chest surgery. FNAB diagnostic performance and clinical efficacy were calculated. Results: Out of 225 patients referred for FNAB, 68 covered inclusion criteria. Forty-nine out of 68 smears (72%) were adequate for diagnosis. Specificity was 100% (95% CI: 77-100%), sensitivity was 100% (95% CI: 90-100%). Positive and negative predictive values were 1.0 (95% CI: 0.9-1.0) and 1.0 (95% CI: 0.77-1.0) respectively. A post-biopsy pneumothorax was detected in 27 cases (39%); the pneumothorax rate was significantly affected by the number of passages (P=0.01). Conclusions: The satisfactory results of our study lead to reconsidering FNAB in patients with pulmonary nodules below 15 mm in diameter, especially in order to avoid unnecessary surgery.

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Fine needle aspiration cytology of lung lesions: a clinicopathological and cytopathological review of 150 cases with emphasis on the relation between the number of passes and the incidence of pneumothorax

Cited by 25 publications

References 31 publications

Role and accuracy of rapid on‐site evaluation of CT‐guided fine needle aspiration cytology of lung nodules

Role and accuracy of rapid on‐site evaluation of CT‐guided fine needle aspiration cytology of lung nodules

Clinical next‐generation sequencing successfully applied to fine‐needle aspirations of pulmonary and pancreatic neoplasms

CT-guided fine-needle aspiration biopsy of solitary pulmonary nodules under 15 mm in diameter: time for an afterthought?

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