Fine needle aspiration cytology of primary lymphoma of the thyroid: a report of 17 cases

Sangalli, Gabriele; Serio, Giovanni; Zampatti, C; Lomuscio, G; Colombo, L

doi:10.1046/j.1365-2303.2001.00338.x

Cited by 110 publications

(80 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, the results of FNAC for the diagnosis of thyroid lymphoma are inconsistent, and its diagnostic accuracy varies widely [7][8][9][10][11]. Sangalli et al reported that FNAC was successful in detecting lymphoma in 76% of cases, and no false-positive cases were found [9].…”

Section: Clinical Characteristics and Treatment Modalities Of Patientmentioning

confidence: 99%

“…However, three of ten patients with MALT lymphoma (30%) were erroneously diagnosed as Hashimoto's thyroiditis, although the other seven patients were diagnosed as or suspected of lymphoma. Therefore, they concluded that the diagnosis of high-grade thyroid lymphoma was fairly easy based on cytomorphological features, and found that immunocytochemistry can be used to confirm suspicious cases [9]. Differentiation of primary thyroid lymphoma from Hashimoto's thyroiditis using FNAC may be difficult, especially when the thyroid lymphoma is of low-grade histology such as MALT lymphoma.…”

Section: Clinical Outcome and Comparison Of The Clinical Characteristmentioning

confidence: 99%

See 1 more Smart Citation

Clinical Characteristics of Primary Thyroid Lymphoma in Koreans

Hwang

Kim

et al. 2009

Endocr J

View full text Add to dashboard Cite

Abstract. Primary thyroid lymphoma is a very rare tumor and its prevalence is approximately 0.1% of all thyroid cancers in Korea. Its clinical experience is limited and not familiar to physicians. Therefore, we performed this study to investigate the clinical characteristics of primary thyroid lymphoma in Koreans. We retrospectively analyzed the medical records of the 44 patients with primary thyroid lymphoma from 1991 to 2006 at four major referral hospitals in Korea. Out of 44 patients, eight patients were male and 36 patients were female and their average age was 57 years. Fifty-six percent of patients had underlying Hashimoto's thyroiditis. All but two patients had non-Hodgkin's lymphoma with B cell origin, and eighty percent of patients presented with stage IE or IIE. Twenty-one of 44 patients (48%) had diffuse large B cell lymphoma (DLBCL) and 17 (39%) had MALT lymphoma. Malignancies originating from lymphoid cells were suspected in 10 of eighteen patients with DLBCL (56%) by using fine-needle aspiration cytology (FNAC), and no difference was noted compared with MALT lymphoma (64%). Compared with DLBCL, the patients with MALT lymphoma were more frequently presented with stage I disease (DLBCL vs. MALT lymphoma: 32% vs. 65%, P=0.04). Moreover, in contrast to DLBCL, most of the patients with MALT lymphoma achieved complete response with treatments (DLBCL vs. MALT lymphoma: 53% vs. 94%, P<0.01). Because of the low diagnostic accuracy of FNAC, thyroid biopsy should be considered for the diagnosis of thyroid lymphomas in suspicious cases. The patients with MALT lymphoma were more frequently presented with early stage diseases and this might lead to the favorable outcome to treatments than those with DLBCL.

show abstract

Section: Clinical Characteristics and Treatment Modalities Of Patientmentioning

confidence: 99%

Section: Clinical Outcome and Comparison Of The Clinical Characteristmentioning

confidence: 99%

Clinical Characteristics of Primary Thyroid Lymphoma in Koreans

Hwang

Kim

et al. 2009

Endocr J

View full text Add to dashboard Cite

show abstract

“…Primary thyroid lymphoma (PTL) is a rare cause of malignancy, accounting for <5%of thyroid malignancies [45] and < 2% of extra-nodal lymphomas [46,47], with an annual estimated incidence of 2 per 1 million [48]. Women are more commonly affected than men (2-8:1) [47,49,50].…”

Section: Hashimoto's Thyroiditis and Thyroid Lymphomamentioning

confidence: 99%

Hashimoto’s Thyroiditis And Cancer: A Review

Salti

2017

int arch med

View full text Add to dashboard Cite

Background: No consensus exists on the association betweenHashimoto's thyroiditis (HT) and cancer. To resolve this controversy, this review aimed to evaluate the relationship between the two conditions. Methods:Using pub-med database, we searched studies relevant to the topic focusing on the association between HT and papillary thyroid cancer (PTC), as well as the association between HT and primary thyroid lymphoma (PTL).Findings: Both HT and PTC are common worldwide, and the two conditions may be closely related. However, the relationship remains controversial. Some studies found that PTC coexisted with HT 2.8-fold more frequently, with variable prevalence ranging from 0.5 to 30%. In contrast to surgical and pathological series that suggested a positive correlation between the two diseases and even a cause-and-effect relationship, the other studies evaluating fine-needle aspirate specimens did not find a statistically significant correlation. On the other hand, the relationship between PTL and HT appears well established. Conclusion:The existing data provide inconsistent evidence favoring a causal relationship between HT and PTC. Prospective studies are needed to further elucidate the relationship. However patients with HT are at risk for PTL. Therefore careful observation and follow-up of HT patients is recommended.

show abstract

“…A fine-needle aspiration biopsy (FNAB) is recommended as the first -line diagnostic procedure, but owing to its low sensitivity and specificity, a core needle biopsy or open surgical biopsy is often necessary. 10 Since the histopathological diagnostic workup is time -consuming, some patients have to be treated before establishing a definite diagnosis. Tracheal compression may be relieved surgically or conservatively, usually with corticosteroids.…”

mentioning

confidence: 99%