Fine Needle Aspiration Cytology in Follicular Dendritic Cell Sarcoma

Fan, Yuen Shan; Ng, Wai-Kuen; Chan, Alice; Chan, Gavin Shueng-wai; Tsang, Janice; Chim, Chor Sang; Ip, Philip

doi:10.1159/000325817

Cited by 29 publications

(22 citation statements)

References 19 publications

(11 reference statements)

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“…Cells were arranged as whorls, syncytia, fascicles, and singly scattered with variable nuclear pleomorphism and nucleoli. As in our case, various features, such as binucleated and multinucleated forms with nuclear grooves and inclusions, mitosis, and Reed-Sternberg-like cells, were also seen [7,11]. One of the case reports described a histiocyte-like appearance of tumor cells resembling granulomas, which were also observed in our case [7,11].…”

Section: Discussionsupporting

confidence: 80%

“…As in our case, various features, such as binucleated and multinucleated forms with nuclear grooves and inclusions, mitosis, and Reed-Sternberg-like cells, were also seen [7,11]. One of the case reports described a histiocyte-like appearance of tumor cells resembling granulomas, which were also observed in our case [7,11]. One report also mentioned Medusa head cells, starfish cells, and interconnecting long cytoplasmic processes as the diagnostic clue for FDCS [12].…”

Section: Discussionsupporting

confidence: 64%

“…Malignant lesions can be differentiated as they usually have hyperchromatic nuclei in contrast to pale nuclei of FDCS. Immunohistochemistry (IHC) may help in confirming this tumor and will show CD21, CD23, and CD35 positivity along with vimentin and SMA, and will be negative for cytokeratins and S-100 protein [11]. …”

Section: Discussionmentioning

confidence: 99%

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Cytomorphological Findings of Follicular Dendritic Cell Sarcoma on Fine-Needle Aspiration Cytology

Ojha¹,

Jain²,

Meenai³

et al. 2017

Acta Cytologica

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Background: Follicular dendritic cell sarcoma (FDCS) is a rare neoplasm arising from follicular dendritic cells of germinal centers. The most common site of origin is lymph nodes and it may mimic a variety of tumors at that location, including carcinomas and sarcomas. Diagnosis is frequently missed on cytology as there are very few case reports describing the cytological characteristics of the lesion. Even on histology, a high degree of suspicion is required for an appropriate diagnosis. Case: A 60-year-old male presented with a gradually increasing left submandibular mass that had been present for 3 months. Fine-needle aspiration cytology (FNAC) was performed, showing many clusters as well as scattered epithelioid cells with spindled to oval nuclei, nuclear pleomorphism, grooves, inclusions, and uniformly dispersed mature lymphocytes throughout the smears. The diagnosis of FDCS was suspected and was confirmed on histopathology and immunohistochemistry. Conclusion: FNAC can be a cheap, easy, and helpful tool in obtaining a diagnosis of FDCS as there are few characteristic cytological features that are better recognized than histology.

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Section: Discussionsupporting

confidence: 80%

Section: Discussionsupporting

confidence: 64%

See 1 more Smart Citation

Cytomorphological Findings of Follicular Dendritic Cell Sarcoma on Fine-Needle Aspiration Cytology

Ojha¹,

Jain²,

Meenai³

et al. 2017

Acta Cytologica

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“…Misdiagnosis occurs frequently due to the rarity of pharyngeal FDCS tumors and similar histopathological characteristics shared with other common pharyngeal tumors, including ectopic meningioma, undifferentiated carcinoma, nerve sheath tumor, inflammatory sarcoma, squamous cell carcinoma, lymphoma and fibrous histiocytoma (2,5,9,14,20,25–32). All three present cases were misdiagnosed.…”

Section: Discussionmentioning

confidence: 99%

Follicular dendritic cell sarcoma of the pharyngeal region

Wang

Chang

et al. 2013

Oncology Letters

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Follicular dendritic cell sarcoma (FDCS) is a rare neoplasm arising most commonly from follicular dendritic cells in the lymph nodes. It is exceedingly rare in extranodal sites, particularly in the pharyngeal region. The present study reports 3 cases occurring in the pharyngeal region. Case 1 had tonsil and cervical lymph node involvement, while case 3 also had tonsil involvement. Cases 1 and 3 relapsed locally at 3 and 17 months after surgery, respectively. Case 2 was diagnosed with a tumor in the parapharyngeal space and the patient succumbed to the disease 5 months after treatment with combined surgery and chemotherapy. All 3 cases were misdiagnosed initially. Pathological biopsy examination, including histopathology and immunohistochemistry, was essential for diagnosis. The data for 52 cases, including cases from the literature and the present cases, were analyzed. The results indicated that 57% (26/46) of the initial diagnoses were inaccurate, while the recurrence, metastasis and mortality rates were 40, 16 and 10%, respectively. The statistics supported the theory that FDCS of the pharyngeal region is a low-grade sarcoma. Involvement of the tonsils (52%, 27/52) and parapharyngeal space (19%, 10/52) were observed most commonly, while FDCS at various sites showed different prognoses. The various survival rates were calculated in the present study. The large tumors (≥4 cm) had a poorer prognosis than the small tumors (<4 cm; P<0.05). Among the 50 cases with available follow-up data, 46% (23/50) were treated with surgery alone, 52% (26/50) with combination therapy (surgery followed by chemotherapy and/or radiotherapy) and 2% (1/50) with surveillance. There was no statistically significant evidence (P>0.05) that combination therapy improves survival rates, compared with surgery alone.

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“…26.21A,B). 126 Occasional pseudonuclear cytoplasmic inclusions and folding of nuclear membrane are seen. In general, there is an intimate admixture with abundant lymphocytes.…”

Section: Follicular Dendritic Cell Sarcomamentioning

confidence: 99%