Fine needle aspiration cytology (FNAC) of salivary gland tumours: Repeat aspiration provides further information in cases with an unclear initial cytological diagnosis

Brennan, Peter A.; Davies, Ben; Poller, David; Mead, Zoe; Bayne, Duncan; Puxeddu, Roberto; Oeppen, R.S.

doi:10.1016/j.bjoms.2008.12.014

Cited by 74 publications

(56 citation statements)

References 22 publications

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“…This histopathological distribution was comparable with the present study. Though FNAC is a readily available, low morbid and cost effective method of diagnosis in major salivary malignancy; the histological diversity of these tumors makes role of FNA controversial (Spiro, 1986;Schlakman and Yousem, 1993;Garden et al, 1997;Brennan et al, 2010). In terms of imaging, MRI remains the radiological tool of choice for assessment of deep lobe parotid tumors, patterns of infiltration and imaging of para-pharyngeal spaces while computed tomography (CT) is most effective when bony erosion is suspected (Armstrong et al, 1992;Burke et al, 2011).…”

Section: Discussionmentioning

confidence: 99%

Ten Year Experience with Surgery and Radiation in the Management of Malignant Major Salivary Gland Tumors

Iqbal¹,

Bhatti²,

Hussain³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Background: Despite being rare in incidence, malignant tumors of major salivary glands show diverse histological variation. There are limited data on major salivary gland tumor management and outcome from Pakistan. The objective of this study was to share our experience with management of malignant tumors of major salivary glands. Materials and Methods: Patients who received treatment at Shaukat Khanum Cancer Hospital and Research Center from July 2002 to June 2011 with an underlying diagnosis of a major salivary gland malignancy were included. Patient characteristics and treatment modalities were assessed. Local, regional and distant failures were determined. Disease free survival (DFS) and overall survival (OS) were calculated using Kaplan Meier curves and the Log rank test was used to determine statistical significance. Univariate and multivariate analyses were performed using Cox proportional hazard regression. Results: The parotid gland was the primary site of origin in 104 (80%) patients. Mucoepidermoid carcinoma (43%) and adenoid cystic carcinoma (24%) were the most common histological types. Surgery followed by adjuvant radiation remained the mainstay treatment modality with 81 (62%) patients. Nineteen (15%) patients were treated with surgery alone and 30 (23%) patients with locally advanced surgically inoperable tumors received radiation only. Forty one (32%) patients failed the treatment (local 12, regional 11, locoregional 5, distant 13). The expected 5 year DFS and OS were 65% and 74% respectively. On multivariate analysis, grade was the only independent predictor of DFS and nodal involvement was the only independent predictor of overall survival. Conclusions: Employing existing standards of treatment, comparable survival can be achieved in Pakistani population with major salivary gland malignancies as elsehwere in the world.

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Section: Discussionmentioning

confidence: 99%

Ten Year Experience with Surgery and Radiation in the Management of Malignant Major Salivary Gland Tumors

Iqbal¹,

Bhatti²,

Hussain³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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“…It is possible to confuse malignant tumours such as mucoepidermoid and adenoid cystic carcinoma (ACC) with benign tumours such as pleomorphic adenoma and vice versa. Hence, it cannot always be relied upon in isolation, and should be used in conjunction with other investigations [4].…”

Section: Introductionmentioning

confidence: 99%

“…Errors may occur in sampling tumours such as carcinoma arising in a pleomorphic adenoma where FNAC can miss the malignant component [4].…”

Section: Introductionmentioning

confidence: 99%

Salivary Gland Tumors: A Diagnostic Dilemma!

Peravali

Bhat

Upadya

et al. 2014

J. Maxillofac. Oral Surg.

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Salivary gland tumors generate considerable interest because of their heterogeneous and variable histology, grade of malignancy, and clinical behavior. Fine needle aspiration cytology (FNAC) is considered the first diagnostic modality for salivary neoplasms due to its ready availability and ease of performance. However it cannot always be relied upon in isolation, and should be used in conjunction with other investigations like incisional biopsy. We present two cases, which highlight the drawbacks of relying on FNAC alone, which resulted in misdiagnosis of adenoid cystic carcinoma as pleomorphic adenoma.

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“…Brennan et al evaluated the utility of repeat fine-needle aspiration in cytological diagnosis of salivary gland lesions for unclear cases in order to improve the diagnosing accuracy. However, the authors have reported the sensitivity and specificity in differentiation malignant from benign lesions similar to the initial examination (70% and 95% before, respectively 84% and 93% after repeated aspiration) [9].…”

Section: Discussionmentioning

confidence: 98%

Efficacy of Fine Needle Aspiration Cytology in Diagnosis of Salivary Gland Tumors

Iacob

Sin

Mezei

et al. 2015

Acta Medica Marisiensis

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Introduction: Masses of the head and neck comprise a variety of benign and malignant tumors and tumor-like conditions, which may present diagnostic challenges to the surgeon and pathologist as well. Fine needle aspiration cytology is considered to be a valuable diagnostic tool used for preoperative evaluation of various masses in the head and neck region. However, its role is quite controversial for salivary gland tumour evaluation. This study was aimed to evaluate salivary gland fine-needle aspiration cytology for sensitivity, specificity and diagnostic accuracy in our medical center. Material and method: The present study included 58 patients with different salivary gland lesions who underwent preoperative fine-needle aspiration procedure followed by surgical procedure and histological examination. The cytological findings were compared with the final histological diagnosis and concordance assessed. Results: Of the 58 cases with salivary gland lesions, most of them involved parotid gland (72.41%), 91.38% were neoplasms and 8.62% were non-neoplastic lesions. Out of 53 neoplasms, 39 were benign and 14 were malignant salivary gland tumors. The sensitivity and a specificity of fine-needle aspiration cytology in differentiation malignancies from benign lesions was 100% and 97.73% respectively. In some situations cytological features could not provide correct tumor characterization. Conclusions: Fine-needle aspiration cytology is a simple and reliable technique for preoperative evaluation of salivary gland tumors with a high sensitivity diagnosis of malignant tumors, but a lower tumor type characterization. Due to the minimally invasive nature of the technique, fine-needle aspiration cytology offers valuable information for planning of subsequent therapeutic management.

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Fine needle aspiration cytology (FNAC) of salivary gland tumours: Repeat aspiration provides further information in cases with an unclear initial cytological diagnosis

Cited by 74 publications

References 22 publications

Ten Year Experience with Surgery and Radiation in the Management of Malignant Major Salivary Gland Tumors

Ten Year Experience with Surgery and Radiation in the Management of Malignant Major Salivary Gland Tumors

Salivary Gland Tumors: A Diagnostic Dilemma!

Efficacy of Fine Needle Aspiration Cytology in Diagnosis of Salivary Gland Tumors

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