Fine-Needle Aspiration Cytologic Study of Myofibroblastoma of the Breast: <i>Immunohistochemical and Ultrastructural Findings</i>

Amin, Mahul B.; Gottlieb, Cary A.; Fitzmaurice, Maryann; Gaba, Arthur R.; Lee, Min Won; Zarbo, Richard J.

doi:10.1093/ajcp/99.5.593

Cited by 38 publications

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“…1,4,5 Intranu- clear cytoplasmic inclusions have not been documented before in BM. [1][2][3][4][5] In our experience, this feature was evident only in Diff-Quik-stained smears. The characteristics of the stroma, either collagenous or myxoid, is mentioned in two previous reports.…”

Section: Discussionmentioning

confidence: 86%

“…Table I summarizes their clinicopathologic findings. [1][2][3][4][5] There were seven men and one woman, ranging in age from 40 to 69 years (mean, 58.3). Size ranged from 1.5 to 3.8 cm (mean, 2.3) in greatest dimension.…”

Section: Discussionmentioning

confidence: 99%

“…[1][2][3][4][5] The cytologic diagnosis is detailed in only four of the cases, and in none of them was a diagnosis of malignancy rendered. [2][3][4] Grooved nuclei (best seen with Papanicolaou stain) were noted in only 50% of cases (not including ours). 1,4,5 Intranu- clear cytoplasmic inclusions have not been documented before in BM.…”

Section: Discussionmentioning

confidence: 99%

“…Outcome was not stated in two cases; the remaining six patients showed no recurrence on follow-up (range, 6-24 months; mean, 12). [1][2][3][4][5] The cytologic diagnosis is challenging, particularly when not all the typical features are present. Furthermore, cytopathologists should bear in mind the well-known heterogeneity of mesenchymal lesions.…”

Section: Discussionmentioning

confidence: 99%

“…[1][2][3][4][5] Tavassoli 6 mentioned a recurrent BM in a 72-year-old woman. Local excision is the treatment of choice.…”

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confidence: 99%

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Fine Needle Aspiration of Breast Myofibroblastoma

López‐Ríos

Burgos²,

Madero³

et al. 2001

Acta Cytologica

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Section: Discussionmentioning

confidence: 86%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

“…[1][2][3][4][5] Tavassoli 6 mentioned a recurrent BM in a 72-year-old woman. Local excision is the treatment of choice.…”

mentioning

confidence: 99%

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Fine Needle Aspiration of Breast Myofibroblastoma

López‐Ríos

Burgos²,

Madero³

et al. 2001

Acta Cytologica

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Imaging characteristics of giant myofibroblastoma of the breast diagnosed by ultrasound-guided core biopsy

Miller

Levine

Simmons

1997

J. Clin. Ultrasound

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Fine-needle aspiration cytology of spindle cell lesions of the breast

Chhieng

Cangiarella

Waisman

et al. 1999

Cancer

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BACKGROUND Fine‐needle aspiration biopsy (FNA) has been successful in diagnosing epithelial lesions of the breast. Its role in the evaluation of spindle cell and mesenchymal lesions of the breast, which include a variety of benign and malignant conditions, is less clear. This article discusses the cytologic features and differential diagnosis of these lesions, as well as the potential diagnostic pitfalls associated with them. METHODS FNAs of the breast, in which a spindle cell or mesenchymal component was a key or dominant feature, were retrieved. Fibroadenomas without cellular stroma and typical lipomas were excluded. RESULTS Forty‐six aspirates (0.87%) in a series of 5306 breast FNAs contained a significant spindle cell or mesenchymal component. The aspirates were classified into 4 categories: 1) reactive conditions, including 2 diabetic mastopathies, 3 granulation tissue specimens, and 7 granulomatous lesions; 2) benign neoplastic conditions, including 1 mammary hamartoma, 1 dermatofibroma, 1 fibromatosis, 2 granular cell tumors, 2 angiolipomas, and 7 cellular fibroadenomas; 3) low grade malignant neoplastic lesions, including 10 low grade phyllodes tumors; and 4) high grade malignant neoplastic lesions, including 1 metaplastic carcinoma with chondroid stroma, 1 pleomorphic liposarcoma, 2 malignant fibrous histiocytomas, 2 osteosarcomas, and 4 metastatic melanomas. A specific diagnosis was rendered in 38 cases (82.6%). The mammary hamartoma was diagnosed as fibrocystic changes; the dermatofibroma as benign spindle cell lesion, not otherwise specified (NOS); and the primary osteosarcoma as an atypical spindle cell proliferation, NOS. The reactive ductal epithelial cells in one of the granulomatous mastitis specimens, as well as the hyperplastic ductal epithelial cells in one of the phyllodes tumors, were interpreted as atypical ductal proliferation. The marked cytologic atypia displayed by one granular cell tumor was interpreted as low grade adenocarcinoma and the primary liposarcoma as poorly differentiated carcinoma. CONCLUSIONS Breast lesions with a significant spindle cell or mesenchymal component are rarely encountered in FNA and constitute a heterogeneous group that may pose a diagnostic dilemma. FNA should be the initial diagnostic procedure for investigating these lesions, as a specific diagnosis was rendered in the majority of cases. Cancer (Cancer Cytopathol) 1999;87:359–71. © 1999 American Cancer Society.

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Fine-Needle Aspiration Cytologic Study of Myofibroblastoma of the Breast: Immunohistochemical and Ultrastructural Findings

Cited by 38 publications

References 0 publications

Fine Needle Aspiration of Breast Myofibroblastoma

Fine Needle Aspiration of Breast Myofibroblastoma

Imaging characteristics of giant myofibroblastoma of the breast diagnosed by ultrasound-guided core biopsy

Fine-needle aspiration cytology of spindle cell lesions of the breast

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