Fine Needle Aspiration Cytodiagnosis of Toxoplasmic Lymphadenitis

Gupta, Raj K.

doi:10.1159/000332784

Cited by 20 publications

(15 citation statements)

References 7 publications

(10 reference statements)

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“…17 The possibility of lymphoma was clinically considered in four and metastatic carcinoma in two of the six cases in a study reported by Gupta. 7 Infection was also one of the possibilities in three cases. In the cytologically diagnosed and reported TL cases, the lymphadenopathy was usually limited to the cervical/submandibular region 7,10,17 except for one case of axillary lymphadenopathy, seen by Gupta, 7 and involvement of an intramammary lymph node, reported by Shimizu et al 13 Our case presented with a suprascapular swelling without constitutional symptoms and was clinically diagnosed as lipoma.…”

Section: Discussionmentioning

confidence: 93%

“…Furthermore, a consideration of TL in the differential diagnosis permits further investigation with serologic confirmation, now that several specific assays are available. 7 Studies on FNA cytologic diagnosis of TL are very few and limited mostly to case reports or small case series. 1,3,7,9,10,13,14,17 Rarely has the demonstration/identification of the morphologic stages of the parasite been reported.…”

Section: Background: Fine Needle Aspiration (Fna) Cytologic Diagnosismentioning

confidence: 99%

“…7 Studies on FNA cytologic diagnosis of TL are very few and limited mostly to case reports or small case series. 1,3,7,9,10,13,14,17 Rarely has the demonstration/identification of the morphologic stages of the parasite been reported. 1,17 We report FNA diagnosis of a suprascapular swelling that was clinically diagnosed as a lipoma.…”

Section: Background: Fine Needle Aspiration (Fna) Cytologic Diagnosismentioning

confidence: 99%

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Fine Needle Aspiration Cytologic Diagnosis of Toxoplasma Lymphadenitis

Pathan¹,

Francis²,

Das³

et al. 2003

Acta Cytologica

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Section: Discussionmentioning

confidence: 93%

Section: Background: Fine Needle Aspiration (Fna) Cytologic Diagnosismentioning

confidence: 99%

Section: Background: Fine Needle Aspiration (Fna) Cytologic Diagnosismentioning

confidence: 99%

See 1 more Smart Citation

Fine Needle Aspiration Cytologic Diagnosis of Toxoplasma Lymphadenitis

Pathan¹,

Francis²,

Das³

et al. 2003

Acta Cytologica

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“…FNA from toxoplasma lymphadenitis samples usually reveals the presence of epithelioid cell granulomas in the background of a polymorphous lymphoid population and histiocytes, and absence of necrosis, suppurative changes and giant cells [15,16,17]. Cytologic smears from lymph node FNA in cat scratch disease generally reveal granulomas with peripherally palisading epithelioid histiocytes and centrally located neutrophils (suppurative granulomas) along with a polymorphous population of lymphoid cells [18,19].…”

Section: Discussionmentioning

confidence: 99%

Fine Needle Aspiration Cytology of Kikuchi-Fujimoto’s Disease: A Report of 2 Cases with Emphasis on Cytologic Features and Differential Diagnosis

Sivakumar¹,

Ramamoorthy

2012

Acta Cytologica

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Background: Kikuchi-Fujimoto’s disease (KFD) or histiocytic necrotizing lymphadenitis is an uncommon, benign, self-limited disease of unknown etiology, primarily affecting young women. Herein, we present the cytologic features of KFD of 2 cases that presented with different clinical pictures and discuss the cytologic differential diagnosis of this condition. Cases: Case 1 was a 17-year-old girl who presented with cervical lymphadenopathy since 6 weeks and case 2 was a 32-year-old female who had cough and axillary lymphadenopathy since 8 weeks. The fine needle aspiration (FNA) smears of both cases revealed a polymorphous lymphoid population intermingled with histiocytes, many of which showed a small size, eccentric location, crescent-shaped nuclei and abundant karyorrhectic debris in the background. A diagnosis of histiocytic necrotizing lymphadenitis was made on FNA cytology, which was confirmed by subsequent histologic examination of the lymph nodes. Conclusion: Precise diagnosis of KFD on cytologic smears is crucial as it can be mistaken for tuberculous lymphadenitis, systemic lupus erythematosus, malignant lymphoma or even metastatic carcinoma, and to avoid unnecessary investigations and potentially harmful treatment. With adequate, well-preserved samples and appropriate clinical setting, the presence of abundant karyorrhectic debris, crescentic macrophages, a polymorphous lymphoid population and absence of epithelioid cell granulomas, giant cells and neutrophils must alert the cytopathologist to arrive at a correct diagnosis.

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“…Most of these patients present with painless lymphadenopathy or asthenia [1]. Lymphadenitis with follicular hyperplasia and non-necrotising granulomatosis on cytology is suggestive of the disease, but correlation with serological titre levels is required for the diagnosis [10,11]. If fine needle aspirate cytology and serology suggest toxoplasmosis infection, no further invasive intervention is required for diagnosis [10,11].…”

Section: Discussionmentioning

confidence: 99%