Fine‐needle aspiration biopsy of prostate synovial sarcoma: A case report and review of the literature

Maleki, Saeed; Cajigas, Antonio; Moss, Jason; Ramesh, Kundal; Khader, Samer

doi:10.1002/dc.23623

Cited by 15 publications

(19 citation statements)

References 14 publications

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“…[1][2][3][4] There are a few case reports of synovial sarcoma diagnosed based on FNA biopsy. [5][6][7][8][9][10][11][12][13][14][15][16] The cases described involved widespread locations such as heart, thyroid, kidney, prostate, large vessels, parapharyngeal space, axilla, and lower extremity.…”

Section: Discussionmentioning

confidence: 99%

Cytological findings of monophasic synovial sarcoma presenting as a lung mass: report of a case and review of the literature

Dermawan

Policarpio‐Nicolas

2019

Diagnostic Cytopathology

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Synovial sarcomas are rare malignant mesenchymal tumors that can arise from any anatomic site. Although they are often located at the paraarticular region of the extremities, the incidence of synovial sarcomas in the lungs is rare, with only a few cytology case reports to date. We report a case of synovial sarcoma presenting as a lung mass diagnosed on fine‐needle aspiration (FNA) cytology. The patient is a 38‐year‐old chronic smoker who presented with cough, worsening dyspnea, and weight loss. Computerized tomography of his chest revealed an 8‐cm left lower lobe pleural‐based mass. An FNA of the lung mass showed cellular smears composed of monotonous population of singly scattered to sheets of bland spindle cells with elongated nuclei, fine chromatin pattern, and scant to moderate amount of delicate cytoplasm. Immunohistochemical stains performed on the cell block showed that the tumor cells were positive for calretinin and focally positive for pancytokeratin, CAM5.2, and smooth muscle myosin heavy chain. The tumor cells were negative for S‐100, podoplanin, and CD34. Fluorescence in situ hybridization performed on the cell block demonstrated the presence of SYT (18q11) translocation, supporting the diagnosis of synovial sarcoma.

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Section: Discussionmentioning

confidence: 99%

Cytological findings of monophasic synovial sarcoma presenting as a lung mass: report of a case and review of the literature

Dermawan

Policarpio‐Nicolas

2019

Diagnostic Cytopathology

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“…Some researchers have reported that the SYT-SSX fusion transcripts are not only a definitive diagnostic marker of SS, but also yield important independent prognostic information (6). It was reported that a patient with a SS bearing the SYT-SSX2 translocation had a better prognosis compared with a patient bearing the SYT-SSX1 translocation (7,8). This conclusion was supported by a multi-institutional retrospective study of 243 SS patients by Ladanyi et al (9).…”

Section: Discussionmentioning

confidence: 91%

Poorly differentiated pulmonary synovial sarcoma with SYT gene amplification: A case report

Zheng

et al. 2018

mol clin onc

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Fluorescence in situ hybridization (FISH) and reverse-transcription polymerase chain reaction (RT-PCR) analysis may be used for the diagnosis of synovial sarcoma (SS), particularly of the poorly differentiated type. While the majority of the studies report that the SYT FISH probe is considered to be break-apart in SS, with two orange and two green signals, the SYT probe in the present case of a 52-year-old male patient with pulmonary SS displayed orange and green signal separation, along with SYT orange signal amplification. RT-PCR was used to verify that the SYT gene amplification was another form of expression of SYT-SSX gene fusion t(X; 18)(p11; q11). In this case, the tumour sample obtained by biopsy was small; therefore, the definitive diagnosis of poorly differentiated SS originating from the lung with SYT gene amplification was confirmed by FISH and RT-PCR. Therefore, these mature biomarkers, which are available as immunohistochemical stains in the molecular pathology laboratory, may help pathologists to diagnose intractable soft tissue tumours based only on small cytological specimens.

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“…Four of the five patients appear to have died of respiratory failure in the setting of pulmonary metastases. 7,13,14,16 On the basis of this very limited data set, the longest reported survival for patients with known metastatic prostatic synovial sarcoma is approximately 3 years after initial diagnosis. Clinical follow-up for our patient is still ongoing.…”

Section: Discussionmentioning

confidence: 99%

“…In the time since Iwasaki and colleagues described the first known case of primary prostatic synovial sarcoma in 1999, only 11 total cases have been reported in the English literature to date. [7][8][9][10][11][12][13][14][15][16] We herein present what we believe is the 12th reported case of primary prostate synovial sarcoma on the basis of the published literature, and to our knowledge is only the second reported case of primary synovial sarcoma of the prostate with pulmonary metastatic disease at presentation.…”

Section: Introductionmentioning

confidence: 97%

Primary Prostatic Synovial Sarcoma With Pulmonary Metastases Identified by Routine Next-Generation Sequencing

Reimers

Sehn

Tine

et al. 2021

JCO Precision Oncology

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Fine‐needle aspiration biopsy of prostate synovial sarcoma: A case report and review of the literature

Cited by 15 publications

References 14 publications

Cytological findings of monophasic synovial sarcoma presenting as a lung mass: report of a case and review of the literature

Cytological findings of monophasic synovial sarcoma presenting as a lung mass: report of a case and review of the literature

Poorly differentiated pulmonary synovial sarcoma with SYT gene amplification: A case report

Primary Prostatic Synovial Sarcoma With Pulmonary Metastases Identified by Routine Next-Generation Sequencing

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