Fine Needle Aspiration Biopsy of Idiopathic Retroperitoneal Fibrosis

Stein, Amy L.; Bardawil, Ronald G.; Silverman, Stuart G.; Cibas, Edmund S.

doi:10.1159/000332539

Cited by 20 publications

(13 citation statements)

References 9 publications

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“…Some authors suggest that cytopathological examination of fine‐needle aspiration (FNA) smears may contribute in establishing a diagnosis of RPF 20–22 . FNA results were found to be consistent with subsequent histopathological examination of tissue biopsy specimens of the same patients 20–22 . However, a non‐specific morphological FNA result is obtained.…”

Section: Discussionmentioning

confidence: 99%

Idiopathic retroperitoneal fibrosis mimicking malignant lymphoma

Bommel¹,

Mol²,

Langerak

et al. 2011

Pathology International

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We present a case of atypical idiopathic retroperitoneal fibrosis (iRPF) presenting as a large pelvic tumor, for which it proved difficult to exclude T-cell malignant lymphoma. Histopathological examination of biopsy material showed collagenous tissue and fat with an exuberant and predominant T-cell infiltrate, largely consisting of CD4(+) cells expressing the IL-2 receptor-α chain (CD25). Focal plasma cells were negative for the immunoglobulin G4 (IgG4) isotype. T-cell receptor gene rearrangement (TRGR) pattern showed a Gaussian distribution, in keeping with a polyclonal T-cell population. Awareness of the sometimes exuberant and predominant T-cell infiltrate in iRPF should lead to earlier consideration of this disorder. This is particularly the case where there is an atypically localized and/or extensive mass, for which early exclusion of monoclonality with TRGR may provide helpful. Immunohistochemical findings suggest that CD4(+) CD25(+) cells, which are part of a naturally occurring population of regulatory T-cells, may be involved in the pathogenesis of iRPF.

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Section: Discussionmentioning

confidence: 99%

Idiopathic retroperitoneal fibrosis mimicking malignant lymphoma

Bommel¹,

Mol²,

Langerak

et al. 2011

Pathology International

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“…18,19 Aggregated fibrous tissue mixed with inflammatory cells can be obtained by ultrasonographyguided accurate puncture of the lesion, and although these are nonspecific findings, they may suggest IRF and decrease suspicion of malignancy. We could not perform this technique in our patient because we thought the tumor originated from the right adrenal gland and there was a possibility of malignancy.…”

Section: Discussionmentioning

confidence: 99%

Tumor-Forming Idiopathic Retroperitoneal Fibrosis: Report of a Case

et al. 2004

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Idiopathic retroperitoneal fibrosis (IRF) is characterized by the progressive proliferation of connective tissue, but it rarely results in the formation of a mass. Herein, we report a rare case of tumor-forming IRF. A 76-year-old woman was referred to our hospital after a tumor in the right retroperitoneum was found by ultrasonography and computed tomography. Magnetic resonance imaging showed a 5 x 8 x 5-cm irregularly shaped tumor, lying adjacent to the right kidney, with a high-intensity T1-weighted image and a high-intensity T2-weighted image. Hormonal levels were within normal limits. Surgery was performed because of the possibility of an adrenal cancer. The tumor was firm, measured 7 x 8 x 4 cm, and weighed 115 g. The pathological diagnosis was retroperitoneal fibrosis. It is very difficult to distinguish tumor-forming IRF from malignancy. Several examinations, including needle aspiration cytology and biopsy, are necessary for the diagnosis and treatment of this disease.

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“…16.15). 165,166 The differential diagnosis includes any lesion with prominent fibrosis and inflammation. In exceptional cases, rare lipoblasts are present in otherwise nonlipogenic areas.…”

Section: Dedifferentiated Sarcomasmentioning

confidence: 99%

“…[164][165][166] nodular fasciitis Nodular fasciitis is a relatively common fibrous proliferation that typically occurs in subcutaneous tissue. Sclerosing mesenteritis usually involves the small bowel mesentery, with more prominent fat necrosis.…”

Section: Differential Diagnosis Of Idiopathic Retroperitoneal Fibrosismentioning

confidence: 99%

Soft Tissue

Qian¹

2009

Cytology

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Fine Needle Aspiration Biopsy of Idiopathic Retroperitoneal Fibrosis

Cited by 20 publications

References 9 publications

Idiopathic retroperitoneal fibrosis mimicking malignant lymphoma

Idiopathic retroperitoneal fibrosis mimicking malignant lymphoma

Tumor-Forming Idiopathic Retroperitoneal Fibrosis: Report of a Case

Soft Tissue

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