Fine‐needle aspiration biopsy of lytic bone lesions: An institution's experience

Shergill, Uday; Vitkovski, Taisia; Stoffels, Guillaume; Klein, Melissa; Gimenez, Cecilia; Laser, Alice; Cocker, Rubina; Chau, Karen; Das, Kasturi

doi:10.1002/dc.23807

Cited by 12 publications

(10 citation statements)

References 14 publications

(20 reference statements)

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“…Among the site-wise distribution, most frequent site of metastases were the pelvic bones and the vertebral column, followed by long bones, bones of the shoulder girdle, and skull. [ 10 ]…”

Section: Discussionmentioning

confidence: 99%

Cytomorphological spectrum of metastatic bone tumors: Experience at a tertiary care center

et al. 2022

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Objectives: Bone is a frequent site of metastases and typically indicates a short-term prognosis in cancer patients. The majority of skeletal metastases are due to breast and prostate cancer. Bone metastasis is actually much more common than primary bone cancers, especially in adults. Fine-needle aspiration cytology (FNAC) provides reasonably accurate pre-operative diagnosis in vast majority of cases. This study aims to elicit the cytomorphological detail of various metastatic bone tumors. Material and Methods: A total of 109 cases of tumors metastatic to bone have been included in this study. The details of the cases were available from the archives of the department of cytology. May Grunwald Giemsa and hematoxylin and eosin stained smears were studied and examined for the cytomorphological spectrum. Cell block and immunohistochemistry tests were done, wherever feasible. Results: Among 109 patients, the mean age was 54.52 years. There was male preponderance with 90 males and 19 females. The most common site of metastases was in the vertebra (82 cases), and 76 cases were in the dorsolumbar region. The most common type of tumor metastasizing was adenocarcinoma. Conclusion: FNAC is a very useful, economical procedure. There are characteristic cytological features of the metastatic lesions and the basic diagnostic categorization of the malignant tumors is possible on FNAC. Regarding the primary source clinical history, radiological features of the primary tumor, if any, and immunocytochemistry may be needed.

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“…Among the site-wise distribution, most frequent site of metastases were the pelvic bones and the vertebral column, followed by long bones, bones of the shoulder girdle, and skull. [ 10 ]…”

Section: Discussionmentioning

confidence: 99%

Cytomorphological spectrum of metastatic bone tumors: Experience at a tertiary care center

et al. 2022

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“…Herein, we found 30 cases of reactive lymph nodes diagnosed by FNAC, which eliminated the hypothesis of lymphomas or metastasis. Regarding the use of FNAC for intra‐osseous lesions, the needle easily passes through the thinned bone cortices and can then contribute to the diagnosis of a variety of odontogenic and non‐odontogenic lesions 8,26 . In our cytological archive, several different intra‐osseous lesions were diagnosed by FNAC, including ameloblastoma, odontogenic keratocyst, periapical/inflammatory cyst, central giant cell lesion, simple bone cyst and Ewing sarcoma, among others.…”

Section: Discussionmentioning

confidence: 99%

An audit of cytopathology in the oral and maxillofacial region: 18 years of experience

et al. 2020

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Introduction: The aim of this study was to perform an audit of oral and maxillofacial specimens submitted for cytological diagnosis to verify the importance of this complementary examination. Methods: A retrospective analysis of our institutional cytopathology database was performed over an 18-year period. Clinical information and cytological data were collected. Associations between independent variables and outcomes were assessed using the Pearson χ 2 test or Fisher's test, with a 5% significance level. When available, the histological diagnosis was compared with cytological diagnosis to identify the percentage of agreement and the specificity, sensitivity and accuracy of cytology in identifying malignant neoplasms. Results: A total of 1082 cases were identified, which included 65 different cytological diagnoses. Exfoliative cytology (EC) was performed in 312 cases (29.1%) and fine needle aspiration cytology (FNAC) in 770 cases (70.9%). EC was mainly employed to diagnose oral infectious diseases (P < 0.001) and FNAC to diagnose neoplasms, cystic, reactive and miscellaneous lesions (P < 0.001). Cell-block was performed in 555 FNAC cases (51.3%). Panoptic, Papanicolaou and haematoxylin-eosin staining were performed in FNAC and periodic acid-Schiff in EC (P < 0.001). In 211 cases (19.5%), the histological diagnosis was available and the percentage agreement with the cytological diagnosis was 41.2%. Sensitivity, specificity, positive predictive value, negative predictive value and accuracy to identify malignant neoplasms were 84.6%, 100%, 100%, 77.8% and 90.0%, respectively. Conclusions: EC was mainly performed for diagnosis of infectious diseases and FNAC for diagnosis of salivary gland tumours, odontogenic lesions, reactive lesions and cervical metastasis. K E Y W O R D S cytopathology, exfoliative cytology, fine needle aspiration cytology, head and neck, oral cavity PÉREZ-DE-OLIVEIRA Et AL. 1 | INTRODUC TI ON Oral diseases can share many clinical aspects, and complementary tests may be needed to achieve a diagnosis. Cytology represents a diagnostic tool based on a microscopic evaluation of the cell samples collected from mucosal surface via exfoliative cytology (EC) or internal sites via fine needle aspiration cytology (FNAC). 1 This complementary examination is widely used in many clinical routines, such as investigation of masses in lymph nodes, liver, thyroid and breast, as well as screening of precursor lesions of cervical carcinoma and follow-up of patients with lung carcinoma. 2,3 In oral diagnosis, the use of cytology examination remains controversial. Previous reports demonstrated that cytopathology can be a useful tool in head and neck lesions. 3,4 Most reports have focused on the thyroid, 5 major salivary gland 6 and cervical lymph node masses, 7 in which, when well indicated, performed and interpreted, cytopathology can achieve a high accuracy to allow for correct therapeutic management. Single reports in the literature suggest that cytopathology applications can go beyond the above-mentioned scenario...

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“…For lytic neoplastic lesions, FNAB and CNB have comparable efficacy, with about 85% adequacy. 140 Fineneedle aspiration biopsy has the advantage of less trauma and the opportunity to assess adequacy during the procedure by the ROSE technique. Using FNAB to identify the lesion followed by CNB to obtain additional tissue is an alternate technique.…”

Section: Bonementioning

confidence: 99%

Needle Biopsy Adequacy in the Era of Precision Medicine and Value-Based Health Care

Pritzker

Nieminen

2019

Archives of Pathology &Amp; Laboratory Medicine

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Context.— Needle biopsy of diseased tissue is an essential diagnostic tool that is becoming even more important as precision medicine develops. However, the capability of this modality to efficiently provide samples adequate for diagnostic and prognostic analysis remains quite limited relative to current diagnostic needs. For physicians and patients, inadequate biopsy frequently leads to diagnostic delay, procedure duplication, or insufficient information about tumor biology leading to delay in treatment; for health systems, this results in substantial incremental costs and inefficient use of scarce specialized diagnostic resources. Objective.— To review current needle biopsy technology, devices, and practice with a perspective to identify current limitations and opportunities for improvement in the context of advancing precision medicine. Data Sources.— PubMed searches of fine-needle aspiration and core needle biopsy devices and similar technologies were made generally, by tissue site, and by adequacy as well as by health economics of these technologies. Conclusions.— Needle biopsy adequacy can be improved by recognizing the importance of this diagnostic tool by promoting common criteria for needle biopsy adequacy; by optimizing needle biopsy procedural technique, technologies, clinical practice, professional education, and quality assurance; and by bundling biopsy procedure costs with downstream diagnostic modalities to provide better accountability and incentives to improve the diagnostic process.

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Fine‐needle aspiration biopsy of lytic bone lesions: An institution's experience

Abstract: FNAB is a reliable tool for diagnosis of bone lesions with comparable diagnostic sensitivity to CNB.

Cited by 12 publications

References 14 publications

Cytomorphological spectrum of metastatic bone tumors: Experience at a tertiary care center

Cytomorphological spectrum of metastatic bone tumors: Experience at a tertiary care center

An audit of cytopathology in the oral and maxillofacial region: 18 years of experience

Needle Biopsy Adequacy in the Era of Precision Medicine and Value-Based Health Care

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