Fine Needle Aspiration Biopsy of Monophasic Spindle Synovial Sarcoma of Lung with Fluorescence in Situ Hybridization Identification of t(x;18) Translocation

Collins, Brian T.; Janney, Christine G.; Ong, Menchu; Cortese, Cherise

doi:10.1159/000325094

Cited by 11 publications

(14 citation statements)

References 15 publications

(12 reference statements)

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“…[49] Review of the literature yields few reports of such tumors, with only isolated cases or small series that often include different types of tumors of this lineage. [710–14] Only 60 cases of synovial sarcoma at pleuropulmonary region were reported in English literature till 2005. [13] The largest reported series of primary pulmonary synovial sarcoma comprised 25 cases, where 7 had chest pain, 9 had hemoptysis, shortness of breath, cough, or fever, and 9 were asymptomatic.…”

Section: Discussionmentioning

confidence: 99%

“…[34] There are only few cytological studies available on synovial sarcoma of soft tissues. [5] Fine needle aspiration (FNA) diagnosis of synovial sarcoma lung is further rare to find in literature[67] and, to the best of authors’ knowledge, not reported from India. Brain metastasis in monophasic synovial sarcoma lung is a very rare and late manifestation.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Primary monophasic synovial sarcoma lung with brain metastasis diagnosed on transthoracic FNAC: Report of a case with literature review

et al. 2012

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Synovial sarcoma is highly malignant tumor of soft tissues, occurring chiefly in the extremities and limb girdle with a propensity for local recurrence and sometimes metastases to the lungs. Primary synovial sarcoma arising in the lungs is rare and brain metastasis as presentation is further uncommon. We report a case of primary monophasic synovial sarcoma lung presenting with brain metastasis in a 35-year-old male patient. The diagnosis was made on percutaneous transthoracic needle aspiration from left-sided pulmonary mass and later confirmed by immunohistochemistry. The utility of preoperative diagnosis by percutaneous aspiration cytology is also stressed.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Primary monophasic synovial sarcoma lung with brain metastasis diagnosed on transthoracic FNAC: Report of a case with literature review

et al. 2012

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“…Review of literature shows only few case reports and small case series that report tumours of similar lineage [1,[11][12][13]. The English literature documents barely 60 cases of synovial sarcoma at pleuropulmonary region till 2005 [14].…”

Section: Discussionmentioning

confidence: 99%

Primary Pleuropulmonary Synovial Sarcoma with Brain Metastases in a Paediatric Patient: An Unusual Presentation

Chirmade

Parikh

Anand

et al. 2017

Advances in Respiratory Medicine

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Primary lung neoplasms are rare in children. The most common primary lung malignancies in children are pleuropulmonary blastoma and carcinoid tumour. Synovial sarcoma (SS) accounts for approximately 1% of all childhood malignancies. In absolute terms, the SS of the lungs and pleura are extremely rare and pose a diagnostic difficulty. Soft tissue sarcomas usually have a high potential for metastases, however, metastasis to the brain is rare, even in widely disseminated disease, and it has been described only in 3 case reports previously. Primary pleuropulmonary SS with brain metastases is even rarer. Here we present a case of an 11-year-old boy who presented with respiratory complaints, viz. fever and cough for 20 days. Initial impression was lung abscess, however, on histopathological, immunohistochemical and molecular study, the disorder was diagnosed as synovial sarcoma. After a week from the first consult, the child developed neurological symptoms, viz., an episode of convulsion and gradually worsening power of the lower limb. Computed tomography scan and Magnetic Resonance Spectroscopy was suggestive of brain metastases. Given the rarity of primary lung neoplasms in children, clinical detection remains a challenge. Delayed diagnoses are common as respiratory symptoms may be attributed to inflammatory or infective processes. Primary pleuropulmonary synovial sarcoma is a rare tumour and it is not known to commonly metastasise to the brain. Though rare, primary pleuropulmonary SS should be considered an important differential among peadiatric primary lung neoplasms due to its potential for curability if detected early, and more aggressive metastatic pattern, e.g. brain metastases making early detection imperative.

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“…[1][2][3][4]11 These balanced chromosomal translocations have not been found in any other human neoplasms. 8,13 It was suggested that a patient with a tumor bearing the SYT-SSX1 translocation has a worse prognosis than a patient with a tumor bearing the SYT-SSX2 translocation. 8,13 It was suggested that a patient with a tumor bearing the SYT-SSX1 translocation has a worse prognosis than a patient with a tumor bearing the SYT-SSX2 translocation.…”

Section: Discussionmentioning

confidence: 99%

“…[1][2][3][4] While synovial sarcoma accounts for 5%-10% of all soft tissue sarcomas, it is exceedingly rare arising in the lung, with pulmonary sarcomas overall comprising less than 0.5% of primary lung malignancies. 7,8 In this report, we detail a case of synovial sarcoma presenting as a central lung mass and its cytologic workup, as well as review the differential diagnosis and steps to cytologic diagnosis of primary pulmonary synovial sarcoma. 5,6 Negative prognostic factors include tumors greater than 5 cm in diameter, age greater than 20 years, incomplete resection, high grade, greater than 10 mitotic figures per 10 high-powered fields, and the SYT-SSX1 variant.…”

Section: Introductionmentioning

confidence: 99%

Synovial sarcoma presenting as a lung mass and diagnosed by cytology

Pyden

Lin

2016

Diagnostic Cytopathology

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Synovial sarcoma is a common soft tissue sarcoma with variable fibrous and epithelial differentiation that rarely arises from other body sites, such as within the lung. A case of a 68-year-old male with an extensive smoking history who presented with chest pain and a primary, central, metabolically active lung mass was reported. The mass was biopsied by bronchial brushing, bronchoalveolar lavage (BAL), and transbronchial fine-needle aspiration (FNA). Cytologic analysis of bronchial brushing, BAL, and FNA revealed single and clusters of atypical spindle cells, oval, or spindle-shaped nuclei with smooth nuclear membranes, hyperchromatic and granular chromatin, scant to moderate and delicate cytoplasm, a high degree of mitotic figures, and a lack of necrosis. Immunohistochemical studies showed that the tumor cells were positive for CD99, BCL2, and CK7. A diagnosis of synovial sarcoma was rendered. The differential diagnosis of primary pulmonary synovial sarcoma is discussed, including neuroendocrine tumors, squamous cell carcinoma, and various sarcomatous tumors.

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Fine Needle Aspiration Biopsy of Monophasic Spindle Synovial Sarcoma of Lung with Fluorescence in Situ Hybridization Identification of t(x;18) Translocation

Cited by 11 publications

References 15 publications

Primary monophasic synovial sarcoma lung with brain metastasis diagnosed on transthoracic FNAC: Report of a case with literature review

Primary monophasic synovial sarcoma lung with brain metastasis diagnosed on transthoracic FNAC: Report of a case with literature review

Primary Pleuropulmonary Synovial Sarcoma with Brain Metastases in a Paediatric Patient: An Unusual Presentation

Synovial sarcoma presenting as a lung mass and diagnosed by cytology

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