Fine Needle Aspiration Biopsy of Metastatic Malignant Melanoma with “Rhabdoid” Features

Slagel, Daniel D.; Raab, Stephen S.; Silverman, Jan F.

doi:10.1159/000332854

Cited by 28 publications

(14 citation statements)

References 12 publications

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“…We procured the paraffin tissue blocks of this case and performed IHC with desmin, S100, and Melan-A, of which the latter two markers were strongly positive (figures 5&6), confirming our cytologic suspicion of melanoma (Siddaraju et al, 2007). Other unusual cytologic features described by the various authors are the papillary fragments with fibrovascular cores (Baloch et al, 1999), myxoid stroma (Elliot et al, 2001) ballon cells (Friedman et al, 1982), signet ring cells (Siddaraju et al, 2007) with pseudolipoblastic appearance (Holck et al, 2002), cells with rhabdoid features (Slagel et al, 1997) and cells arranged in alveolar pattern . Although rare, a divergent differentiation such as chondroid, neural, myofibroblastic, and osteocartilagenous differentiation is well known in melanomas; and the lack of awareness of this fact can create serious diagnostic problems to the evaluator.…”

Section: Microscopic Examination Of Cytologic Samplessupporting

confidence: 70%

Clinical Cytology in the Diagnosis and Management of Melanoma

Siddaraju¹

2011

Current Management of Malignant Melanoma

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Section: Microscopic Examination Of Cytologic Samplessupporting

confidence: 70%

Clinical Cytology in the Diagnosis and Management of Melanoma

Siddaraju¹

2011

Current Management of Malignant Melanoma

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“…In this regard, metastatic melanomas with predominant population of spindle cell, lipid-rich balloon cell, signet-ring cell, and rhabdoid cell have been reported. [23][24][25][26] Correlation of FNA cytologic findings with patient's known his- tory of melanoma and previous histologic findings (if available) plays a vital role in the diagnosis of metastatic melanoma. The diagnosis can be confirmed by positive immunostaining for S-100, MelanA, and/or HMB-45.…”

Section: Discussionmentioning

confidence: 99%

Fine‐needle aspiration cytology of metastatic eccrine porocarcinoma

Olsen

Lowe

et al. 2009

Diagnostic Cytopathology

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Eccrine porocarcinoma (EP), although rare, is widely recognized as the most common malignant sweat gland tumor. EP typically grows slowly and usually is cured by surgical excision with clear margins. An elevated mortality rate, however, is observed when regional lymph nodes are involved. We herein describe cytohistologic findings in a case of metastatic EP. An 86-year-old man with a history of EP of the left lateral ankle and squamous cell carcinoma in situ (Bowen's disease) of the penis presented with enlarged left inguinal lymph nodes. A superficial fine-needle aspiration (FNA) was performed and demonstrated a hypercellular sample with discohesive clusters and/or individual tumor cells. The tumor cells were round or oval with most of the cells showing dense, refractile cytoplasm. Intracytoplasmic vacuoles were readily appreciated in some of the cells. Nuclear enlargement, high N/C ratio, nuclear hyperchromasia, bi- and multinucleation, and prominent nucleoli were seen. A diagnosis of metastatic eccrine porocarcinoma was rendered. Enlarged retroperitoneal lymph nodes were detected and CT-guided left retroperitoneal core biopsy was performed 1 week later. The biopsy revealed features consistent with metastatic eccrine porocarcinoma.

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“…A correct cytologic diagnosis of proximal-type epithelioid sarcoma depends on immunochemical analysis 1,2,4 because rhabdoid cells also appear in other diseases, such as synovial sarcoma, extraskeletal myxoid chondrosarcoma, malignant mesothelioma, extrarenal rhabdoid tumor, malignant melanoma and metastatic carcinoma. 7,8 When rhabdoid cells are observed, determination of malignancy and poor prognosis is simple, but it is difficult to confirm a cytologic diagnosis of proximaltype epithelioid sarcoma solely on the basis of Papanicolaou staining. Clinical and immunochemical findings are important for a correct diagnosis.…”

Section: Discussionmentioning

confidence: 99%