Fine Needle Aspiration Biopsy in the Diagnosis of Intraocular Cancer

Augsburger, James J.; Shields, Jerry A.; Folberg, Robert; Lang, Warren R.; O’Hara, Brian J.; Claricci, Joseph D.

doi:10.1016/s0161-6420(85)34068-x

Cited by 139 publications

(76 citation statements)

References 12 publications

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“…Sampling from outside the lesion or from a non-representative portion of the neoplasm might explain some of the negative biopsies, especially when the specimens were harvested blindly through a scleral approach. Inadequate specimens for diagnosis were also reported by others, especially in small compact, solid tumours, but have also been reported from lesions more than 4.5mm thick (Augsburger et al 1985;Char & Miller 1995). Repeating the FNAB after irradiation in two of our cases yielded no further information, and therefore we now attempt to avoid dry taps by having a cytopathologist attending the operating team.…”

Section: Discussionsupporting

confidence: 54%

“…This is much higher than found by Shields et al (1993), who performed FNAB only in 2.5% of patients with suspected intraocular tumours. Many ophthalmologists accept a FNAB only in cases with a severe uncertainty of the diagnosis of intraocular lesions (Augsburger et al 1985). On the other hand, oncologists in general demand a tissue diagnosis prior to the initiation of treatment.…”

Section: Discussionmentioning

confidence: 99%

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Fine needle aspiration biopsy in selecting treatment for inconclusive intraocular disease

Eide

Syrdalen

Walaas

et al. 1999

Acta Ophthalmologica Scandinavica

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ABSTRACT.Purpose: To evaluate the fine needle aspiration biopsy (FNAB) as a diagnostic tool in cases where it was impossible to make a definitive diagnosis with noninvasive techniques. Method: 80 consecutive patients with inconclusive diagnoses were examined by FNAB prior to decision of treatment. Biopsies were performed through a transscleral route in 50 eyes, an anterior chamber route in 16 eyes and a transvitreal approach in 14 eyes. The consequences of FNAB were analysed retrospectively. Results: FNAB confirmed malignancy in 59 eyes. Inconclusive material was obtained from 5 eyes judged clinically to be malignant disorders. One melanoma was misinterpreted as being a metastasis. In 47.5% of our patients this procedure altered the therapeutic plan and 25 patients were spared enucleation. The biopsy material was correctly diagnosed as benign in 16 cases. Conclusion: In eyes where the diagnosis remained uncertain after non-invasive tests, FNAB gave important information which greatly influenced our choice of treatment. FNAB contained sufficient tissue elements for cytological diagnosis in 77 eyes. Cytopathological interpretation failed once in relation to tumour type. The procedure of FNAB can be recommended for use in ambiguous tumour cases of the eye. Probably it should only be used in tumour centres with adequate cytology service.

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Section: Discussionsupporting

confidence: 54%

Section: Discussionmentioning

confidence: 99%

Fine needle aspiration biopsy in selecting treatment for inconclusive intraocular disease

Eide

Syrdalen

Walaas

et al. 1999

Acta Ophthalmologica Scandinavica

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“…If the diagnosis cannot be established with non-invasive tests, fineneedle aspiration biopsy (FNAB) is the most useful diagnostic tool (Char 1989), and is regarded as safe and reliable (Augsburger et al 1985;Shields et al 1993). In certain cases of disseminated cancer diseases, locating the primary tumour site can have important therapeutical consequences.…”

Section: Iagnosis Of a Uveal Tumour Ismentioning

confidence: 99%

Fine‐needle aspiration biopsy diagnosis of a uveal metastasis from a follicular thyroid carcinoma

Ritland

Eide

Walaas

et al. 1999

Acta Ophthalmologica Scandinavica

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ABSTRACT.Purpose: To report a rare tumour of the eye, and to illustrate the importance of performing a fine-needle aspiration biopsy. Case report: An 80-year-old woman suffering from general malaise, dyspnea and abdominal pain was found to have multiple lung metastases, a large tumour in the upper part of the mediastinum, and a large orange-brown tumour (19¿15¿11 mm) situated nasally in the left eye. Fine-needle aspiration biopsy of the uveal tumour and of the goitre was performed. Cytological examination from the two sites disclosed cells compatible with a follicular thyroid carcinoma of oxyfil cell-type. Results: The patient underwent a total thyroidectomy and has so far had 2 series of 131 I therapy. Additionally, the eye tumour was treated locally with a 125 I plaque, and three months later the tumour thickness had decreased from 11.0 to 6.4 mm. Best-corrected visual acuity is still unchanged. The patient's general state improved as her dyspnea decreased significantly. Conclusion:The treatment has improved the patient's quality of life, and probably prolonged her life expectancy. Fine-needle aspiration biopsy was necessary to establish the diagnosis.

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“…O primeiro artigo sobre biópsia aspirativa em oftalmologia foi publicado por Veasey em 1951 e o tumor em questão era um sarcoma (3) . Vários outros artigos sobre biópsia em oftalmologia foram publicados desde então, entretanto nenhum deles apresentava casuística e tempo de seguimento suficientes para consagrar esta modalidade diagnóstica (4)(5)(6)(7)(8) .…”

Section: Introductionunclassified

“…Recentemente a biópsia aspirativa tem sido estudada com o objetivo de: 1 -elucidar casos suspeitos, onde todos os outros recursos se mostraram inconclusivos, 2 -correlacionar o tipo tumoral (celular) com outros focos tumorais (metastáticos), e 3 -confirmar o diagnóstico clínico quando há recusa ou dúvida quanto ao tratamento por parte do paciente (4)(5)(6) .…”

Section: Introductionunclassified

O uso da biópsia aspirativa com agulha fina (BAAF) no diagnóstico de lesão iriana suspeita: relato de caso

Corrêa¹,

Marcon²

2001

Arq. Bras. Oftalmol.

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Fine Needle Aspiration Biopsy in the Diagnosis of Intraocular Cancer

Cited by 139 publications

References 12 publications

Fine needle aspiration biopsy in selecting treatment for inconclusive intraocular disease

Fine needle aspiration biopsy in selecting treatment for inconclusive intraocular disease

Fine‐needle aspiration biopsy diagnosis of a uveal metastasis from a follicular thyroid carcinoma

O uso da biópsia aspirativa com agulha fina (BAAF) no diagnóstico de lesão iriana suspeita: relato de caso

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