Fine-needle aspiration biopsy diagnosis of round cell malignant tumors of childhood. A combined light and electron microscopic approach

Akhtar, Mohammed; Ali, Muhammad; Sabbah, Rajeh; Bakry, Mohammed; Nash, Joan E.

doi:10.1002/1097-0142(19850415)55:8<1805::aid-cncr2820550828>3.0.co;2-6

Cited by 81 publications

(38 citation statements)

References 12 publications

(3 reference statements)

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“…9 The exact categorization is not possible at the light microscopic level in the case of poorly differentiated tumours which poses a considerable challenge to the diagnostic skill of the cytopathologist. 10,11 Primitive neuroectodermal tumour (PNET) is a malignant small round cell tumour arising from the soft tissue or bone, predominantly affecting the older children and adults. The term PNET includes malignant small round cell tumours of the thoracopulmonary region (Askin's tumour), Extra skeletal Ewing's sarcoma, peripheral neuroblastoma, and peripheral epithelioma.…”

Section: Discussionmentioning

confidence: 99%

Malignant Small Round Cell Tumour (Pnet) of Palate: A Rare Cytological Diagnosis

Nibhoria¹,

Tiwana²,

Nibhoria³

et al. 2013

jemds

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Section: Discussionmentioning

confidence: 99%

Malignant Small Round Cell Tumour (Pnet) of Palate: A Rare Cytological Diagnosis

Nibhoria¹,

Tiwana²,

Nibhoria³

et al. 2013

jemds

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“…These procedures, now well established in surgical pathology, may also be applied to aspiration biopsies. [8][9][10] We feel that application of these techniques will undoubtedly enhance the diagnostic efficiency and accuracy of FNAB.…”

Section: Discussionmentioning

confidence: 99%

Role of Cell Block in The Interpretation of Fine-Needle Aspiration Biopsies

1988

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This study is based on a retrospective analysis of 210 fine-needle aspiration biopsies in which both cytology smears and paraffin cell blocks were available. The histology slides from these cell blocks were reviewed, and the cases were subdivided into three categories. In category A, which included 118 (56%) cases, a definitive histologic diagnosis of the presence as well as type of the cancer could be made. In category B, including 56 (27%) of cases, only the presence of cancer could be ascertained, but the type could not be defined. In category C, which consisted of 36 (17%) cases, the tissue was insufficient for reliable diagnosis. Carcinomas were most likely to have cell blocks in category A (65%) as compared to sarcomas (28%) or lymphomas (9%). Comparison of the cytologic diagnosis based on aspiration smears with the cell block diagnosis revealed that in 6% of cases only cell block was positive, while in another 8% of cases the diagnosis from the cell block was more precise and specific. These results indicate that cell blocks can enhance the effectiveness of fine-needle aspiration biopsy in establishing a pathologic diagnosis of cancer. 1 This technique has the advantage over other forms of biopsies because it is reliable, rapid, inexpensive, and relatively painless. Although FNAB is now accepted universally as an important initial step for investigating a patient with a clinically suspicious mass, there are still significant difficulties in using this technique to establish a definitive pathologic diagnosis of cancer. Therefore, in many cases, FNAB is followed by a confirmatory histologic biopsy prior to instituting radical therapy. This raises serious doubts about the value of FNAB as a diagnostic technique. 2-5One way to obviate this difficulty may be to use FNAB as a combined cytologic and histologic technique. 6,7 This is accomplished by submitting part of the FNAB sample for a cell block examination. This study was undertaken to evaluate the feasibility of making a definitive histologic diagnosis based on the examination of cell blocks prepared from FNAB samples.

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“…Electron microscopy preparations also reveal cells that have a high nuclear cytoplasmic ratio and are arranged singly without any cell junctions ( Figure 1C). The cytoplasm contains only a few mitochondria, large numbers of free ribosomes, and scattered non-membrane-bound lipid vacuoles [6].…”

Section: Morphological Featuresmentioning

confidence: 99%