Fine Mapping of the Body Fat QTL on Human Chromosome 1q43

Aissani, Brahim; Wiener, Howard W.; Zhang, Kui

doi:10.1371/journal.pone.0153794

Cited by 4 publications

(3 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In several studies, the WDR64 gene has been associated with obesity 56 and hematological malignancies 57 . Some of the other WDR gene family members were found to be associated with neurodevelopment disorders and brain malformations 58,59 .…”

Section: Resultsmentioning

confidence: 99%

Discovery of host genetic factors through multi-locus GWAS against Toxoplasmosis in sheep: Addressing One Health perspectives

YAMAN,

BAY,

KİŞİ

2024

Preprint

View full text Add to dashboard Cite

T. gondii stands as one of the most successful pathogens, capable of infecting nearly all warm-blooded species. It is estimated that up to 50% of human populations could harbor Toxoplasmosis infections. Among the primary transmission routes is the consumption of tissue cysts from infected food-producing farm animals. Thus, controlling Toxoplasmosis in farm animals is of vital importance for public health and food safety. The implementation of selective breeding in farm animals, where available, could serve as an effective complementary strategy for eradicating Toxoplasmosis from herds. For this purpose, we conducted four multi-locus genome-wide association (GWA) approaches to uncover the underlying polygenic factors involved in innate resistance to Toxoplasmosis in naturally infected sheep. Our findings indicate that 16 SNPs significantly influence host immunity against T. gondii infection. This study marks the initial exploration of host genetic factors against Toxoplasmosis in livestock, utilizing the ovine paradigm as its foundation.

show abstract

Section: Resultsmentioning

confidence: 99%

Discovery of host genetic factors through multi-locus GWAS against Toxoplasmosis in sheep: Addressing One Health perspectives

YAMAN,

BAY,

KİŞİ

2024

Preprint

View full text Add to dashboard Cite

show abstract

“…The G allele at rs11014566, which predicts lower EE and higher FM and BMI, has a frequency of 0.60 in full-heritage Pima Indians, which is higher than the frequency for this allele observed among any of the 1000G populations. Notably, this allele is uncommon in Europeans (MAF < 0.01), and thus its assessment for association with BMI in the GIANT (Genetic Investigation of ANthropometric Traits) consortium ( 33 ) is not optimal. Therefore, we assessed association with BMI in data sets collected from Asians ( 34 ), Africans ( 35 ) and Hispanics ( 26 ).…”

Section: Discussionmentioning

confidence: 99%

“…GPR158 binds to the regulator of G-protein signaling 7 (RGS7) in the nervous system ( 42 , 43 ). RGS7-deficient mice are protected from obesity ( 44 ), and previous studies have provided evidence that RGS7 may constitute an obesity locus in humans ( 33 , 45 ). In addition to RGS7 , GPR158 also binds to an N-type voltage-gated calcium channel (CACNA1B) in the rat brain ( 34 ).…”

Section: Discussionmentioning

confidence: 99%

A Genome-Wide Association Study Using a Custom Genotyping Array Identifies Variants inGPR158Associated With Reduced Energy Expenditure in American Indians

et al. 2017

View full text Add to dashboard Cite

Pima Indians living in Arizona have a high prevalence of obesity, and we have previously shown that a relatively lower energy expenditure (EE) predicts weight and fat mass gain in this population. EE is a familial trait (heritability = 0.52); therefore, in the current study, we aimed to identify genetic variants that affect EE and thereby influence BMI and body fatness in Pima Indians. Genotypic data from 491,265 variants were analyzed for association with resting metabolic rate (RMR) and 24-h EE assessed in a whole-room calorimeter in 507 and 419 Pima Indians, respectively. Variants associated with both measures of EE were analyzed for association with maximum BMI and percent body fat (PFAT) in 5,870 and 912 Pima Indians, respectively. rs11014566 nominally associated with both measures of EE and both measures of adiposity in Pima Indians, where the G allele (frequency: Pima Indians = 0.60, Europeans <0.01) associated with lower 24-h EE (β = −33 kcal/day per copy), lower RMR (β = −31 kcal/day), higher BMI (β = +0.6 kg/m2), and higher PFAT (β = +0.9%). However, the association of rs11014566 with BMI did not directionally replicate when assessed in other ethnic groups. rs11014566 tags rs144895904, which affected promoter function in an in vitro luciferase assay. These variants map to GPR158, which is highly expressed in the brain and interacts with two other genes (RGS7 and CACNA1B) known to affect obesity in knockout mice. Our results suggest that common ethnic-specific variation in GPR158 may influence EE; however, its role in weight gain remains controversial, as it either had no association with BMI or associated with BMI but in the opposite direction in other ethnic groups.

show abstract

A longitudinal genome-wide association study of bone mineral density mean and variability in the UK Biobank

He¹,

Liu²,

Wei³

et al. 2023

Osteoporos Int

View full text Add to dashboard Cite

Fine Mapping of the Body Fat QTL on Human Chromosome 1q43

Cited by 4 publications

References 40 publications

Discovery of host genetic factors through multi-locus GWAS against Toxoplasmosis in sheep: Addressing One Health perspectives

Discovery of host genetic factors through multi-locus GWAS against Toxoplasmosis in sheep: Addressing One Health perspectives

A Genome-Wide Association Study Using a Custom Genotyping Array Identifies Variants inGPR158Associated With Reduced Energy Expenditure in American Indians

A longitudinal genome-wide association study of bone mineral density mean and variability in the UK Biobank

Contact Info

Product

Resources

About