Abstract:Coiled‐coil domain is a structural motif found in proteins crucial for achievement of central biological processes, such as cellular cohesion or neuro‐transmission. The coiled‐coil fold consists of alpha‐helices bundle that can be repeated to form larger filament. Hydrophobic residues, distributed following a regular seven‐residues’ pattern, named heptad pattern, are commonly admitted to be essential for the formation and the stability of canonical coiled‐coil repeats. Here we investigated the first three coil… Show more
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