Findings in [99mTc]MAA SPECT/CT in the diagnosis and follow-up of pulmonary embolism after infection by SARS-CoV-2 (COVID-19)

Hernández, Marylin Acuña; Avellaneda, Tatiana Morales; Gomez, Jorge Andres Narvaez; Orduz, Liset Sanchez

doi:10.5603/nmr.2021.0029

Cited by 4 publications

(4 citation statements)

References 3 publications

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“…One of the most important diagnostic procedures that nuclear medicine can perform is an imaging test that uses 99m Tc-MAA radiopharmaceutical. Findings of several studies supported the observation that the frequency of this usage increased during pandemic 20 , 21 .…”

Section: Discussionsupporting

confidence: 62%

The effect of COVID-19 on nuclear medicine and radiopharmacy activities: A global survey

Al-Saeedi

Rajendran

Tipre

et al. 2023

Sci Rep

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Globally, COVID-19 affected radiopharmaceutical laboratories. This study sought to determine the economic, service, and research impacts of COVID-19 on radiopharmacy. This online survey was conducted with the participation of employees from nuclear medicine and radiopharmaceutical companies. The socioeconomic status of the individuals was collected. The study was participated by 145 medical professionals from 25 different countries. From this work, it is evident that 2-deoxy-2-[18F]fluoro-D-glucose (2-[18F]FDG), and 99mTc-labeled macro aggregated albumin 99mTc-MAA were necessary radiopharmaceuticals used by 57% (83/145and 34% (49/145;) respondents, respectively for determining how COVID infections affect a patient’s body. The normal scheduling procedure for the radiopharmacy laboratory was reduced by more than half (65%; 94/145). In COVID-19, 70% (102/145) of respondents followed the regulations established by the local departments. Throughout the pandemic, there was a 97% (141/145) decrease in all staffing recruitment efforts. The field of nuclear medicine research, as well as the radiopharmaceutical industry, were both adversely affected by COVID-19.

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Section: Discussionsupporting

confidence: 62%

The effect of COVID-19 on nuclear medicine and radiopharmacy activities: A global survey

Al-Saeedi

Rajendran

Tipre

et al. 2023

Sci Rep

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“…Labelled albumin systems have great potential in the diagnosis of various diseases. Particles labelled with a γemitting radionuclide are used to evaluate perfusion in the diagnosis of pulmonary embolism [57][58][59] and β-emitting microspheres are used to evaluate lung shunt fraction in the treatment planning of liver tumours [60][61][62]. Developing a blood-pool agent is also possible to evaluate cardiac functions under psychological and pathological conditions [63].…”

Section: Introductionmentioning

confidence: 99%

Agglomerated serum albumin adsorbed protocatechuic acid coated superparamagnetic iron oxide nanoparticles as a theranostic agent

Bozoglu

Arvas

Varlı³

et al. 2023

Nanotechnology

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Iron oxide nanoparticles have been one of the most widely used nanomaterials in biomedical applications. However, the incomplete understanding of the toxicity mechanisms limits their use in diagnosis and treatment processes. Many parameters are associated with their toxicity such as size, surface modification, solubility, concentration and immunogenicity. Further research needs to be done to address toxicity-related concerns and to increase its effectiveness in various applications. Herein, colloidally stable nanoparticles were prepared by coating magnetic iron oxide nanoparticles (MIONPs) with protocatechuic acid (PCA) which served as a stabilizer and a linkage for a further functional layer. A new perfusion agent with magnetic imaging capability was produced by the adsorption of biocompatible passivating agent macro-aggregated albumin (MAA) on the PCA-coated MIONPs. PCA-coated MIONPs were investigated using infrared spectroscopy, thermogravimetric analysis and dynamic light scattering while adsorption of MAA was analysed by transmission electron microscopy (TEM), Fourier-transform infrared spectroscopy (FT-IR) and x-ray diffraction (XRD) methods. Magnetic measurements of samples indicated that all samples showed superparamagnetic behaviour. Cytotoxicity results revealed that the adsorption of MAA onto PCA-coated MIONPs provided an advantage by diminishing their toxicity against the L929 mouse fibroblast cell line compared to bare Fe3O4.

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“…One of the most important diagnostic procedures that nuclear medicine can perform is an imaging test that uses 99m Tc-MAA radiopharmaceutical. Many studies' ndings support the observation that the frequency of this usage increased during the pandemic [20,21].…”

Section: Discussionmentioning

confidence: 54%

The effect of COVID-19 on nuclear medicine: A global survey

Al-Saeedi

Rajendran

Tipre

et al. 2022

Preprint

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Background: Globally, COVID-19 affected radiopharmaceutical laboratories. This study sought to determine the economic, service, and research impacts of COVID-19 on radiopharmacy. Methods: This online survey was conducted with the participation of employees from nuclear medicine and radiopharmaceutical companies. Results: The socioeconomic status of the individuals was collected. The study was participated by 145 medical professionals from 25 different countries. From this work, it is evident that 18F-fluorodeoxyglucose ([¹⁸F]FDG), and Tc-99m macro aggregated albumin (99mTc-MAA) were necessary radiopharmaceuticals 57% and 34% respectively for determining how COVID infections affect a patient's body. The normal scheduling procedure for the radiopharmacy laboratory was reduced by more than half (65%). In COVID-19, 70% of respondents followed the regulations established by the local departments. Throughout the pandemic, there was a 97% decrease in all staffing recruitment efforts. Conclusions: The field of nuclear medicine research as well as the radiopharmaceutical industry were both adversely affected by COVID-19.

show abstract

Findings in [99mTc]MAA SPECT/CT in the diagnosis and follow-up of pulmonary embolism after infection by SARS-CoV-2 (COVID-19)

Cited by 4 publications

References 3 publications

The effect of COVID-19 on nuclear medicine and radiopharmacy activities: A global survey

The effect of COVID-19 on nuclear medicine and radiopharmacy activities: A global survey

Agglomerated serum albumin adsorbed protocatechuic acid coated superparamagnetic iron oxide nanoparticles as a theranostic agent

The effect of COVID-19 on nuclear medicine: A global survey

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