Findings by an International Collaboration on SJS/TEN With Severe Ocular Complications

Ueta, Mayumi

doi:10.3389/fmed.2021.649661

Cited by 7 publications

(5 citation statements)

References 46 publications

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“…International Collaboration on SJS/TEN With Severe Ocular Complications indicated cold medicines, including NSAIDs, as the main group of drugs inducing studied pathology among Japanese patients. Both for Japanese and Korean patients HLA-A*02:06 was implicated, and in Japanese-, Indian-, and European ancestry Brazilian patients-HLA-B*44:03 [67]. Non-HLA factors also may contribute to SJS and TEN.…”

Section: Discussionmentioning

confidence: 99%

Stevens–Johnson Syndrome and Toxic Epidermal Necrolysis: Analysis of the Russian Database of Spontaneous Reports

Zyryanov,

Asetskaya,

Butranova

et al. 2024

Pharmaceuticals

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(1) Background: Stevens–Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are extremely severe cutaneous adverse drug reactions which are relatively rare in routine clinical practice. An analysis of a national pharmacovigilance database may be the most effective method of obtaining information on SJS and TEN. (2) Methods: Design—a retrospective descriptive pharmacoepidemiologic study of spontaneous reports (SRs) with data on SJS and TEN retrieved from the Russian National Pharmacovigilance database for the period from 1 April 2019 to 31 December 2023. Descriptive statistics was used to assess the demographic data of patients and the structure of suspected drugs. (3) Results: A total of 170 SRs on SJS and TEN were identified, of which 32.9% were SJS and 67.1%—TEN. In total, 30% were pediatric SRs, 21.2%—SRs of the elderly. There were 12 lethal cases, and all cases were TEN. The leading culprit drugs were anti-infectives for systemic use and nervous system agents. The top 10 involved drugs are as follows: lamotrigine (23.5%), ibuprofen (12.9%), ceftriaxone (8.8%), amoxicillin and amoxicillin with beta-lactam inhibitors (8.8%), paracetamol (7.6%), carbamazepine (5.9%), azithromycin (4.1%), valproic acid (4.1%), omeprazole (3.5%), and levetiracetam (3.5%). (4) Conclusions: Our study was the first study in Russia aimed at the assessment of the structure of the drugs involved in SJS and TEN on the national level.

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Section: Discussionmentioning

confidence: 99%

Stevens–Johnson Syndrome and Toxic Epidermal Necrolysis: Analysis of the Russian Database of Spontaneous Reports

Zyryanov,

Asetskaya,

Butranova

et al. 2024

Pharmaceuticals

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“…We have suspected that a common function of CMs such as acetaminophen and dipyrone is highly implicated in the onset of SJS/TEN with SOC ( Ueta et al, 2010a ; Ueta, 2016 ; Ueta, 2018 ; Ueta, 2020 ; Ueta, 2021a ; Ueta, 2021b ).…”

Section: Hla Association With Cm-related Sjs/ten With Socmentioning

confidence: 99%

“…The common function of CMs is the suppression of prostaglandin E 2 (PGE 2 ) production. We have suggested that the common function of CMs might be important for the onset of CM-related SJS/TEN with SOC ( Ueta et al, 2010a ; Ueta, 2016 ; Ueta, 2018 ; Ueta, 2020 ; Ueta, 2021a ; Ueta, 2021b ) because PGE 2 suppresses mucocutaneous inflammation ( Kunikata et al, 2005 ; Ueta et al, 2009a ; Honda et al, 2009 ); PGE 2 acts on EP3 (PGE 2 receptor 3) in the epidermis ( Honda et al, 2009 ) and the mucosal epithelium such as the conjunctival ( Ueta et al, 2009a ) and tracheal epithelium ( Kunikata et al, 2005 ), and it negatively regulates mucocutaneous inflammation ( Kunikata et al, 2005 ; Ueta et al, 2009a ; Honda et al, 2009 ). We have suspected that CMs including acetaminophen and NSAIDs could upregulate inflammatory responses by suppressing the production of PGE 2 which suppresses mucocutaneous inflammation, that they augment abnormal immune responses, and that they elicit the induction of SJS/TEN with SOC ( Ueta et al, 2010a ; Ueta, 2016 ; Ueta, 2018 ; Ueta, 2020 ; Ueta, 2021a ; Ueta, 2021b ).…”

Section: Susceptibility Genes For Cm-related Sjs/ten With Socmentioning

confidence: 99%

Susceptibility Genes and HLA for Cold Medicine-Related SJS/TEN with SOC

Ueta

2022

Front. Genet.

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We investigated the genetic predisposition for the pathogenesis of Stevens–Johnson syndrome/epidermal necrolysis with severe ocular complications (SJS/TEN with SOC). Cold medicines (CMs) including multi-ingredient cold-medications and non-steroidal anti-inflammatory drugs (NSAIDs) were implicated in the development of SJS/TEN with SOC. Studies on the association between HLA genotypes and CM-related SJS/TEN with SOC (CM-SJS/TEN with SOC) revealed an association with HLA-A*02:06 in the Japanese; it may be a marker in Koreans. HLA-B*44:03 was associated with the Japanese, Thais, and Indians; in Brazilians of European ancestry, it may be a positive marker. PTGER3 is a susceptibility gene; HLA-A*02:06 and PTGER3 polymorphisms exerted additive effects in Japanese and Korean patients. A genome-wide association study showed that IKZF1 was associated with the Japanese. A meta-analysis including Japanese, Koreans, Indians, and Brazilians also revealed an association between CM-SJS/TEN with SOC and IKZF1. The upregulation of hsa-miR-628-3p in the plasma of SJS/TEN with SOC patients may suppress the expression of TLR3 and innate immune-related genes. Not only CMs but also the interaction of TLR3, PTGER3, IKZF1, and HLA and maybe some microbial infections are necessary for the onset of SJS/TEN with SOC.

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“…Chest X ray revealed diffuse opacity, more intensive at the basis of the lungs, which correlated with bronchopneumonia. Granulysin and CCL-27 serum markers are elevated in patients with SJS/TEN and can be helpful markers to monitor disease severity, reported in recent studies [12,13,14]. Further research is required before these markers can be reliably used for diagnosis [15,16].…”

Section: Case Reportmentioning

confidence: 99%

“…Approximately 50% of SJS/TEN patients diagnosed by dermatologists and/or in burn units suffer from severe ocular complications (SOC) such as severe conjunctivitis with pseudomembrane and ocular surface epithelial defects in the acute stage. In the chronic this results in sequelae such as severe dry eye and visual disturbance [13].…”

Section: Case Reportmentioning

confidence: 99%

Case report of a patient with toxic epidermal necrolysis with complications and review of literature

Petrovic-Popovic

Petrovic-Elbaz

2022

Srp Arh Celok Lek

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Introduction. Toxic epidermal necrolysis (TEN), also known as Lyell?s syndrome, is rare exfoliative disorder with high mortality rate. This entity was first described by Lyell in 1956, who termed the condition ?toxic epidermal necrolysis', pointing out that drug sensitization was generally considered to be the mechanism leading to this syndrome. The drugs most frequently involved are nonsteroidal anti-inflammatory drugs (NSAID), chemotherapeutic agents, antibiotics, and anticonvulsants, although virus, bacterial, and fungal infections, as well as immunization, have been described. Case outline. We present a 72-year-old man with the following history. Five days before he was admitted patient have had high fiver and pain throat. He was treated with antibiotics and nonsteroidal anti-inflammatory drugs (NSAID) because had had bronchopneumonia and after that he developed itchy skin rash over all body following with sensation of slight sore throat with conjunctival hyperaemia and hard breathing and high fiver and because of this he was hospitalized in the local hospital. After worsening of symptomatology following with urticaria like plaques and then bullae with progress all over the body patient was moved to our Institution and positioned in intensive care unit, under suspicion of TEN. The aim of the paper presented here is to give a thorough summary of our literature review searching for the best therapy modalities for our patient with TEN. Conclusion. We decided to present this case because our patient had been affected with lesions of multiorgan system and with affecting 80% TBSA and SCROTEN score 4. With early diagnosed of TEN patient was successfully treated.

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Findings by an International Collaboration on SJS/TEN With Severe Ocular Complications

Cited by 7 publications

References 46 publications

Stevens–Johnson Syndrome and Toxic Epidermal Necrolysis: Analysis of the Russian Database of Spontaneous Reports

Stevens–Johnson Syndrome and Toxic Epidermal Necrolysis: Analysis of the Russian Database of Spontaneous Reports

Susceptibility Genes and HLA for Cold Medicine-Related SJS/TEN with SOC

Case report of a patient with toxic epidermal necrolysis with complications and review of literature

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