Finding potential inhibitors against RNA-dependent RNA polymerase (RdRp) of bovine ephemeral fever virus (BEFV): an in-silico study

Abstract

RenalOCT2 substrate Yes No No AV4 AV5 AV6 Physicochemical Properties Formula C18H22N2O6 C9H14Cl2N2O2 C9H11NO3 Molecular weight 362.38 g/mol 253.13 g/mol 181.19 g/mol Molar Refractivity 95.05 63.84 47.19 TPSA 167.10 Ų 89.34 Ų 72.55 Ų Lipophilicity Log Po/w (iLOGP) 1.96 0 1.21 Log Po/w (XLOGP3) -4.02 -0.6 -1.73 Log Po/w (WLOGP) 0.69 1.84 0.46 Log Po/w (MLOGP) -3.99 -1.1 -1.7 Log Po/w (SILICOS-IT) 0.39 0.15 0.54 Consensus Log Po/w -0.99 0.06 -0.24 Water Solubility Log S (SILICOS-IT) -1.29 -1.5 -1.59 Solubility 1.86e+01 mg/ml 7.91e+00 mg/ml 4.68e+00 mg/ml Class Soluble Soluble Soluble Pharmacokinetics GI absorption

Türkiye’de Üç Gün Hastalığı ve Ekonomik Boyutu

“…Bovine Ephemeral Fever (BEF), which is an economically important viral disease, was first described in 1906 in South Africa (Öztürk 2012;Pyasi et al 2021). This is locally referred to as three-day disease since infected animals usually recover after three days (Kirkland 2002;Walker 2009).…”

“…BEF, apart from the Culicine and Anopheline mosquitoes, especially the stinging flies of the genus Anopheles bancroftii and Culicoides are considered as potential biological vectors of the disease, and the disease can also occur with the bites of these flies or the injection of the virus (Alkan et al 2017). Although the disease first appears sporadically, the morbidity rate reaches 100% at the end of the incubation period (Tonbak et al 2013a;Abdullah et al 2020;Pyasi et al 2021). Animals that survive a BEF outbreak become immune for life and are very rarely reinfected (Tonbak et al 2013b).…”