Finding of Hyperostosis Frontalis Interna During the Autopsy Procedure: Forensic Issues

Bascou, Agathe; Savall, F.; Vergnault, Mathieu; Montoriol, Romain; Guilbeau‐Frugier, Céline; Maupoint, Estelle; Khal, Mohamed Chérif El; Telmon, Norbert

doi:10.1111/1556-4029.14100

Cited by 5 publications

(4 citation statements)

References 33 publications

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“…It has been observed that before the nineteenth and twentieth centuries, there was less prevalence of HFI which contributed to less life span during that time. Thus, human longevity in recent eras, the microevolution of human endocrine regulation by sex steroids, and lifestyle changes like obesity, Type 2 Diabetes Mellitus have also contributed to the increased prevalence of HFI [ 9 , 10 ].…”

Section: Discussionmentioning

confidence: 99%

Hyperostosis Frontalis Interna in a Dry Indian Human Skull: A Case Report

Banik¹,

Gaikwad²,

Deep³

2023

Cureus

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Hyperostosis Frontalis Interna (HFI), a condition that has been sparsely explained till now, is a benign, asymptomatic, and irregular thickening of the endocranium of the frontal bone. It is found to be predominantly present in post-menopausal women during incidental X-ray or CT/MRI of the skull. The prevalence of HFI is documented in different populations, but in the Indian population, it is comparatively rare. Thus, we discuss a serendipitous finding of HFI in an Indian skull. This rare variation was noted in dry Indian human skulls. Gross features of the skull were noted, and it was an adult female skull. The area was decalcified, paraffin-embedded, and stained with Haematoxylin and Eosin. The skull bone was also subjected to plain X-ray/CT investigation. The X-ray skull of 50+ year female type features in anteroposterior and lateral view showed widening of the diploic spaces 8-10 mm with ill-defined hyperdense areas in the frontal region. Changes in computed tomography were noted. HFI often has nonspecific and benign symptoms. However, in severe cases, widespread clinical implications starting from headache, motor aphasia, parkinsonism, and depression can occur, and thus we all should be aware of it.

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Section: Discussionmentioning

confidence: 99%

Hyperostosis Frontalis Interna in a Dry Indian Human Skull: A Case Report

Banik¹,

Gaikwad²,

Deep³

2023

Cureus

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“…5 Hiperostozis frontalis internanın ayırıcı tanıları arasında fokal kitleler, subdural ve dural kalsifikasyon gibi patolojiler yer almaktadır. 6 Olgumuzda kronik subdural hematom kalsifikasyonu ile karışmıştır. Bu durum, olgumuzla benzer şekilde en çok menopoz sonrası kadınlarda görülür.…”

Section: Discussionunclassified

Medicolegal Evaluation of the Effect of Radiological Examination Reports on Criminal Judgment Through a Case of Hyperostosis Frontalis Interna

BALTACI¹,

YILMAZ²,

Çakmak³

et al. 2022

Turkiye Klinikleri J Foren Sci Leg Med

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Hiperostozis frontalis interna, frontal kemiğin iç plakasının benign büyümesi ile karakterizedir. 1 Kronik subdural hematom, genellikle yaralanmadan sonra, 21 günden fazla, duranın altında kan göllenmesi olarak tanımlanmaktadır. Kronik kalsifiye subdural hematom insidansı, tüm kronik subdural hematomların %0,3-2,7'sidir. 2 Türk Ceza Kanunu'nun (TCK) 86, 87 ve 89. maddelerinde de belirtildiği gibi ceza kanunumuz yaralama suçlarında faile verilecek cezanın oranını be-

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“…The condition now known as HFI was first described by Morgagni based on his autopsy of an elderly woman showing obesity and hirsutism (Morgagni, 1719). While the changes to the internal table of the frontal bone are diagnostic of HFI, more than 300 years after its initial description, the exact etiology of the condition is still unresolved (Bascou et al, 2019; Raikos et al, 2011). Several endocrine, metabolic, and neuropsychiatric signs and symptoms are reported to frequently accompany HFI.…”

Section: Introductionmentioning

confidence: 99%

Pronounced hyperostosis frontalis interna and co‐occurring lesions in the skull base suggestive of a pituitary tumor in a woman from medieval Germany

Flohr,

Witzel,

Kierdorf

2023

Intl J of Osteoarchaeology

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Hyperostosis frontalis interna (HFI) is an osseous overgrowth characterized by symmetrical, irregular bone apposition on the internal table of the frontal bone, which preferentially occurs in females. In 1719, Morgagni described the condition as one sign of a triad comprising HFI, hirsutism, and obesity (Morgagni's syndrome). The etiopathogenesis of HFI is largely unresolved, but the condition is frequently associated with metabolic, endocrine, and neuropsychiatric disorders. In archaeological cases, which rely solely on dry bone diagnosis, the cause of HFI generally remains unknown, as is also the case regarding accompanying signs and symptoms. Here, we report a case of pronounced HFI in the skeleton of an old‐adult woman from medieval Hildesheim dating to the 8th to 11th century CE. In addition to HFI, the cranium exhibits resorptive lesions of the sella turcica with dehiscence of the roof of the sphenoid sinus. The co‐occurrence of these lesions suggests an underlying common cause for them. On the basis of differential diagnosis, we consider a functioning pituitary neuroendocrine tumor (PitNET) as the most likely common cause for the two conditions.

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Finding of Hyperostosis Frontalis Interna During the Autopsy Procedure: Forensic Issues

Cited by 5 publications

References 33 publications

Hyperostosis Frontalis Interna in a Dry Indian Human Skull: A Case Report

Hyperostosis Frontalis Interna in a Dry Indian Human Skull: A Case Report

Medicolegal Evaluation of the Effect of Radiological Examination Reports on Criminal Judgment Through a Case of Hyperostosis Frontalis Interna

Pronounced hyperostosis frontalis interna and co‐occurring lesions in the skull base suggestive of a pituitary tumor in a woman from medieval Germany

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