Finding new sources from “using different plants as the same herb”: A case study of Huang-lian in Northwest Yunnan, China

Zhang, Yu; Geng, Ying; Zhang, Lingling; Wang, Li; He, Li; Wang, Chen; Chai, Zhen-Zhen; Fan, Ruyan; Li, Shan; Wang, Yuhua

doi:10.1016/j.jep.2015.04.051

Cited by 5 publications

(6 citation statements)

References 28 publications

(27 reference statements)

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“…Coptis chinensis is a perennial herb that belongs to the family Ranunculaceae. Among 16 species distributed all over the world, 6 distribute in Sichuan, Guizhou, Yunnan, and Shanxi provinces of western China ( Zhang Y. et al, 2015 ; Xue et al, 2017 ). For centuries, its dried rhizomes have been widely used in traditional Chinese medicine (TCM) ( Kamath et al, 2009 ; Xiang et al, 2016 ) for heat clearing, dampness drying, fire draining, and detoxification ( Zhang et al, 2011 ; Yang et al, 2017 ).…”

Section: Introductionmentioning

confidence: 99%

“…are respectively called “Weilian,” “Yalian,” and “Yunlian” in the Chinese Pharmacopeia (version 2010) ( Yang et al, 2012 ; Li et al, 2013 ). Among these, C. chinensis is the most important raw material because it is widely distributed and has a high yield, whereas C. teeta is an endangered species ( Zhang Y. et al, 2015 ). Previously, people thought that the three species could be used interchangeably because of their similar phytochemical contents (mainly alkaloids) ( Lv et al, 2016 ).…”

Section: Introductionmentioning

confidence: 99%

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Identification and Characterization of Genes Involved in Benzylisoquinoline Alkaloid Biosynthesis in Coptis Species

Cong

et al. 2018

Front. Plant Sci.

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The dried rhizomes of Coptis chinensis have been extensively used in heat clearing, dampness drying, fire draining, and detoxification by virtue of their major bioactive components, benzylisoquinoline alkaloids (BIAs). However, C. teeta and C. chinensis are occasionally interchanged, and current understanding of the molecular basis of BIA biosynthesis in these two species is limited. Here, berberine, coptisine, jatrorrhizine, and palmatine were detected in two species, and showed the highest contents in the roots, while epiberberine were found only in C. chinensis. Comprehensive transcriptome analysis of the roots and leaves of C. teeta and C. chinensis, respectively, identified 53 and 52 unigenes encoding enzymes potentially involved in BIA biosynthesis. By integrating probable biosynthetic pathways for BIAs, the jatrorrhizine biosynthesis ill-informed previously was further characterized. Two genes encoding norcoclaurine/norlaudanosoline 6-O-methyltransferases (Cc6OMT1 and Cc6OMT2) and one gene encoding norcoclaurine-7OMT (Ct7OMT) catalyzed enzymatically O-methylate (S)-norcoclaurine at C6 that yield (S)-coclaurine, along with a smaller amount of O-methylation occurred at C7, thereby forming its isomer (isococlaurine). In addition, scoulerine 9-OMT (CtSOMT) was determined to show strict substrate specificity, targeting (S)-scoulerine to yield (S)-tetrahydrocolumbamine. Taken together, the integration of the transcriptome and enzyme activity assays further provides new insight into molecular mechanisms underlying BIA biosynthesis in plants and identifies candidate genes for the study of synthetic biology in microorganisms.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Identification and Characterization of Genes Involved in Benzylisoquinoline Alkaloid Biosynthesis in Coptis Species

Cong

et al. 2018

Front. Plant Sci.

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“… 12 Quality of traditional medicines, affected by many factors such as variety, cultivation, processing, transportation, and storage supervision, is the basis for ensuring the efficacy and safety of drugs in clinical use. 13 If the quality of the herbal medicine is not qualified, for example, the effective ingredient does not meet the standards or contain toxic components, it will affect the clinical therapeutic effect and the adverse reaction events caused by the natural drug. Authenticity, advantages and disadvantages play a vital role in clinical efficacy, and some even endanger the lives of people.…”

Section: Quality Of Traditional Medicines: the Core Of Drug Safety An...mentioning

confidence: 99%

Recent advances and effective strategies in the discovery and applications of natural products

et al. 2018

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Natural products are the most representative form of conventional therapy as compared to any other traditional or alternative medicine systems. They have numerous active components, either primary or secondary metabolites, which are associated with the diverse, intricate, and distinct characteristics of natural products and result in various pharmacological effects in clinic. However, some problems are associated with research on herb quality, which is the core of the drug industry, and restrict the development of this field to a certain extent. Quality-markers (Q-markers), a novel concept for quality assessment, open up a new avenue for promotion of healthy development of traditional medicine industry and improvement of the quality standard system to enhance traditional medicine or product quality standards. In this study, we first summarized the main factors affecting the quality of traditional medicines and natural products and importance for safety and then presented the concept of background and relevant factors of Q-markers. Moreover, the modern science technology and related methods used to identify the chemical composition have been discussed. Especially, based on the systematic analysis and discussion of the basic properties and clinical features of natural products, we have discussed new trends and effective strategies for identifying relevant Q-markers from herbs and probed the future research directions and challenges.

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“…Participating in markets is an important way for people to exchange goods, information and knowledge. As "showing stages" of local knowledge, local markets have been the focus of many researchers [26]. Local food markets are systems for food material and information exchange that deliver health, economic, environmental and social benefits to local communities [27].…”

Section: Introductionmentioning

confidence: 99%

The secret of health in daily cuisine: typical healthy vegetables in local markets in central Myanmar

Zhang

San

et al. 2020

J Ethnobiology Ethnomedicine

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Background Central Myanmar is located in the Indo-Burma biodiversity hotspot, and the Bamar people are the main ethnic group, which settled there over 1000 years ago. Despite being the core region of the country, central Myanmar has been ignored in previous ethnobotanical studies. Local healthy foods and knowledge are regarded as treasures for resource development and pharmaceutical drug discovery, and market surveys are a good strategy in ethnobotanical research. Thus, we collected and documented typical vegetables and local knowledge in local markets and then analysed the diversity and local knowledge of these vegetables. Materials and methods Observations and interviews were used in the field study, and 10 markets and fairs were selected in central Myanmar. A total of 277 vegetable stalls or shops were visited. We compared the local knowledge we collected with selected important and typical herbal books on traditional Myanmar medicine. Quantitative analysis, including frequency of citation (FC), relative frequency of citation (RFC) and use value (UV), was used to assess the diversity and local knowledge of these vegetables. Results A total of 132 plant taxa from 47 botanical families and 116 genera were collected. Most (106 taxa, 80.3%) of these vegetables were cited by the informants as functional foods that had health benefits, while others were regarded as merely “good for health”. The main health function of the vegetables was treating digestive problems. Sixty-four species were recorded in selected herbal books on traditional Myanmar medicine, and forty-seven taxa were not recorded in these books but were nonetheless used as healthy vegetables by local people. Twenty-eight species of vegetables were collected from wild places. Conclusion The diversity and local knowledge of healthy vegetables in central Myanmar were rich. Nevertheless, the diversity of wild vegetables was seemingly relatively low. The possible reason was that we counted only the vegetables that were from entirely wild sources as “wild vegetables”. The most frequently cited vegetables were commonly cultivated species, which reflects the fact that plants cultivated on a large scale comprise the major source of vegetables. Some lesser known vegetables could reflect the unique food culture of local people, but most of these were cited only a few times by the interviewees, which caused low UV and RFC rankings for them in the league table. In addition, future research should pay more attention to the food safety of these vegetables.

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Finding new sources from “using different plants as the same herb”: A case study of Huang-lian in Northwest Yunnan, China

Cited by 5 publications

References 28 publications

Identification and Characterization of Genes Involved in Benzylisoquinoline Alkaloid Biosynthesis in Coptis Species

Identification and Characterization of Genes Involved in Benzylisoquinoline Alkaloid Biosynthesis in Coptis Species

Recent advances and effective strategies in the discovery and applications of natural products

The secret of health in daily cuisine: typical healthy vegetables in local markets in central Myanmar

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