Abstract:Among the several variants of the
highly useful and versatile Robinson
annulation, a particular variation that involves ketones reacting
with nonenolizable enones, while the α-carbons of the ketones
act as nucleophiles at both steps of this cascade process, remains
largely unexplored. Moreover, such a catalytic enantioselective reaction
is exceptionally rare. While pursuing catalysis of this transformation,
we developed two fluorogenic assays that, in combination with other
analytic techniques, enabled rapid s… Show more
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