Finding Genetic Risk Factors of Gestational Diabetes

Kwak, Soo Heon; Jang, Hak Chul; Park, Kyong Soo

doi:10.5808/gi.2012.10.4.239

Cited by 27 publications

(28 citation statements)

References 33 publications

(38 reference statements)

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“…The cause of this impaired expansion response is not known but is certainly associated with gene variants leading to an improper proliferation response to the pregnancy hormones. As gestational diabetes is associated with increased risk of developing type 2 diabetes later in life , this suggests that the adaptive mechanisms that lead to beta cell proliferation in response to the transient insulin resistance of pregnancy also play a role in the life‐long adaptation of beta cell mass and function. Identification of the genes conferring susceptibility to gestational diabetes mellitus would be of great interest.…”

Section: Adult Beta Cell Plasticitymentioning

confidence: 99%

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The required beta cell research for improving treatment of type 2 diabetes

Thorens

2013

J Intern Med

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In healthy individuals, insulin resistance is associated with physiological conditions such as pregnancy or body weight gain and triggers an increase in beta cell number and insulin secretion capacity to preserve normoglycaemia. Failure of this beta cell compensation capacity is a fundamental cause of diabetic hyperglycaemia. Incomplete understanding of the molecular mechanisms controlling the plasticity of adult beta cells mechanisms and how these cells fail during the pathogenesis of diabetes strongly limits the ability to develop new beta cell-specific therapies. Here, current knowledge of the signalling pathways controlling beta cell plasticity is reviewed, and possible directions for future research are discussed.

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Section: Adult Beta Cell Plasticitymentioning

confidence: 99%

“…Identification of the genes conferring susceptibility to gestational diabetes mellitus would be of great interest. Currently available evidence suggests the participation of the already identified type 2 diabetes genes CDKAL1 and MTNR1B .…”

Section: Adult Beta Cell Plasticitymentioning

confidence: 99%

The required beta cell research for improving treatment of type 2 diabetes

Thorens

2013

J Intern Med

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“…Until now, no studies have focused on the relationship between MTNR1A gene variants and GDM. Previous investigations have yielded controversial results on the impact of MTNR1B gene variations on the development of GDM [19,20,21]. In the current study, we examined the relationship between the rs2119882 SNP of MTNR1A and rs10830962 and rs10830963 of MTNR1B and the pathogenesis of GDM and further determined whether these genes contribute to endocrinologic and clinical traits of patients with GDM.…”

Section: Introductionmentioning

confidence: 99%

Association between Genetic Variations in MTNR1A and MTNR1B Genes and Gestational Diabetes Mellitus in Han Chinese Women

Li¹,

Qiao

Zhan³

et al. 2013

Gynecol Obstet Invest

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Background/Aims: The purpose of this study was to investigate the association between MTNR1A and MTNR1B gene polymorphisms and gestational diabetes mellitus (GDM) in Han Chinese women. Methods: Study participants included 350 patients with GDM and 480 control subjects. Three single-nucleotide polymorphisms (SNPs; rs2119882 in MTNR1A and rs10830963 and rs10830962 in MTNR1B) were genotyped using direct sequencing. Genotype and allele distributions of SNPs in cases of GDM and controls were analyzed. Association of the MTNR1A and MTNR1B gene variants with plasma glucose and insulin levels as well as blood lipid levels was further investigated. Results: The frequencies of genotypes and allele types of rs2119882 in MTNR1A and rs10830963 in MTNR1B were significantly different between women with GDM and controls (p < 0.05). Moreover, in the GDM group, these SNPs were associated with increased fasting plasma glucose concentrations (p < 0.001) and increased homeostasis model assessment of insulin resistance (p < 0.001). The rs10830962 polymorphism in MTNR1B was not associated with an increased risk of developing GDM or any of the clinical or metabolic characteristics in patients with GDM (p > 0.05). Conclusion: The genetic polymorphisms rs2119882 in MTNR1A and rs10830963 in MTNR1B are associated with an increased risk of developing GDM and insulin resistance in Han Chinese women.

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“…Melatonin receptor 1B (MTNR1B) is a novel candidate gene contributing to type 2 diabetes mellitus (T2DM) (Chambers et al, 2009). Currently, several large-scale genome-wide association analyses demonstrate that the common variants in or near the MTNR1B gene are robustly associated with T2DM (Kwak et al, 2012). Specifically, there are significant associations between increased risks of developing T2DM and GDM and single nucleotide polymorphism (SNP) rs10830963, a widely researched locus (Kim et al, 2011;Vlassi et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

Association between the rs4753426 polymorphism in MTNR1B with fasting plasma glucose level and pancreatic β-cell function in gestational diabetes mellitus

Zhan

Gao

et al. 2015

Genet. Mol. Res.

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ABSTRACT. We investigated the association between rs4753426 single nucleotide polymorphisms in the melatonin receptor 1B (MTNR1B) gene and the risk of developing gestational diabetes mellitus (GDM). A total of 516 gravidas (186 with GDM and 330 non-diabetic controls) were enrolled in the study. Genotype and allele frequencies of rs4753426 in the MTNR1B gene were detected by DNA sequencing. Fasting plasma glucose and fasting insulin levels were measured to calculate the homeostasis model assessment for insulin resistance (HOMA-IR) and for b-cell function. Three genotypes (CC, CT, and TT) were found in both groups. The frequencies of CC, CT, and TT genotypes for the GDM group were 70.97, 22.58, and 6.45% vs 53.03, 39.70, and 7.27% in the control group, respectively. Significant differences were observed in genotype frequencies between groups (P < 0.05). T and C allele frequencies in the GDM group were 17.74 and 82.26%, respectively, and in the control group were 27.12 and 72.88%, respectively. Significant differences in T and C allele frequencies were found between groups (P < 0.05). In the GDM group, the C allele was associated with increased fasting plasma glucose level and reduced pancreatic b-cell function (P < 0.05). There were no significant differences in total cholesterol, triglyceride, low-density lipoprotein, high-density lipoprotein concentration, or HOMA-IR between groups (P > 0.05). The single nucleotide polymorphism rs4753426 in MTNR1B may be a susceptibility gene locus for GDM, and the C allele may contribute to the increased fasting plasma glucose level and reduced pancreatic b-cell function.

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Finding Genetic Risk Factors of Gestational Diabetes

Cited by 27 publications

References 33 publications

The required beta cell research for improving treatment of type 2 diabetes

The required beta cell research for improving treatment of type 2 diabetes

Association between Genetic Variations in MTNR1A and MTNR1B Genes and Gestational Diabetes Mellitus in Han Chinese Women

Association between the rs4753426 polymorphism in MTNR1B with fasting plasma glucose level and pancreatic β-cell function in gestational diabetes mellitus

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