Finding Cures for Alzheimer's Disease

Huang, Xianhai; Aslanian, Robert

doi:10.1002/9781119627784.ch4

Cited by 1 publication

(1 citation statement)

References 151 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The initial occurrence associated with AD is the accumulation of Aβ, which can lead to cerebral amyloid angiopathy . The buildup of Aβ surrounding blood vessels has the potential to cause pericyte death and altered astrocyte morphology, consequently compromising BBB integrity (Figure B) . Another major pathology hallmark in AD is the presence of tau deposits .…”

Section: Abnormal Bbb Structure In Cns Diseasesmentioning

confidence: 99%

Functionalized Nanomaterials Capable of Crossing the Blood–Brain Barrier

Zha,

Liu,

et al. 2024

ACS Nano

View full text Add to dashboard Cite

The blood−brain barrier (BBB) is a specialized semipermeable structure that highly regulates exchanges between the central nervous system parenchyma and blood vessels. Thus, the BBB also prevents the passage of various forms of therapeutic agents, nanocarriers, and their cargos. Recently, many multidisciplinary studies focus on developing cargo-loaded nanoparticles (NPs) to overcome these challenges, which are emerging as safe and effective vehicles in neurotheranostics. In this Review, first we introduce the anatomical structure and physiological functions of the BBB. Second, we present the endogenous and exogenous transport mechanisms by which NPs cross the BBB. We report various forms of nanomaterials, carriers, and their cargos, with their detailed BBB uptake and permeability characteristics. Third, we describe the effect of regulating the size, shape, charge, and surface ligands of NPs that affect their BBB permeability, which can be exploited to enhance and promote neurotheranostics. We classify typical functionalized nanomaterials developed for BBB crossing. Fourth, we provide a comprehensive review of the recent progress in developing functional polymeric nanomaterials for applications in multimodal bioimaging, therapeutics, and drug delivery. Finally, we conclude by discussing existing challenges, directions, and future perspectives in employing functionalized nanomaterials for BBB crossing.

show abstract