“Find Me” and “Eat Me” signals: tools to drive phagocytic processes for modulating antitumor immunity
Lingjun Xiao,
Louqian Zhang,
Ciliang Guo
et al.
Abstract:Phagocytosis, a vital defense mechanism, involves the recognition and elimination of foreign substances by cells. Phagocytes, such as neutrophils and macrophages, rapidly respond to invaders; macrophages are especially important in later stages of the immune response. They detect “find me” signals to locate apoptotic cells and migrate toward them. Apoptotic cells then send “eat me” signals that are recognized by phagocytes via specific receptors. “Find me” and “eat me” signals can be strategically harnessed to… Show more
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