Finasteride induced depression: a prospective study

Rahimi-Ardabili, Babak; Pourandarjani, Ramin; Habibollahi, Peiman; Mualeki, Amir

doi:10.1186/1472-6904-6-7

Cited by 105 publications

(84 citation statements)

References 43 publications

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“…The results are similar to literature data and according to BDI are as follows: 12 points for psoriasis, 12.11 ±7.50 points for male pattern alopecia and 5.87 ±4.68 points in the course of hidradenitis suppurativa [23][24][25]. In our study, 42% of patients suffered from depression of different severity before the therapy, which dropped to 18% after the intervention.…”

Section: Discussionsupporting

confidence: 79%

Self-reported depression and sense of disease in cosmetic patients

Magdziarz-Orlitz¹,

Gerlicz-Kowalczuk²,

Dziankowska‐Bartkowiak³

2012

pdia

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A Ad dd dr re es ss s f fo or r c co or rr re es sp po on nd de en nc ce e: : Zofia A. Gerlicz-Kowalczuk MD, Department of Immunodermatology, Medical University of Lodz, 5 Krzemieniecka, Poland, Original paper A b s t r a c t I In nt tr ro od du uc ct ti io on n: : An increasing number of patients with various personality disorders, psychological problems and depression due to real or imaginary cosmetic defects visit a doctor. A Ai im m: : Evaluation of the relationship between cosmetic problems and self-reported depression in individuals electing to undergo cosmetic procedures, sense of disease in these individuals as well as the relationship between selfreported disease and depression. M Ma at te er ri ia al l a an nd d m me et th ho od ds s: : Investigations using Beck Depression Inventory (BDI) and Self-Esteem Scale (SES) were carried out on 167 patients, before and 4 weeks after the procedure. R Re es su ul lt ts s: : There is a statistically significant difference (p < 0.001) between mean values of measurements before (9.3 points) and after (6.12 points) surgical procedures. The percentage of patients with different severity of depression before the procedure decreased from 42% to 18%. Using SES, the problem was assessed in the following categories: Obstacle, Challenge, Threat, Injustice, Benefit and Importance. The difference between mean scores before and following the intervention was 6.52 points and was statistically significant (p < 0.05). C Co on nc cl lu us si io on ns s: : The results obtained confirm that depression has an impact on self-reported disease and in the case of the investigated group it may be assumed that the aesthetic defect is a disease.K Ke ey y w wo or rd ds s: : depression, sense of disease, cosmetic dermatology.

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Section: Discussionsupporting

confidence: 79%

Self-reported depression and sense of disease in cosmetic patients

Magdziarz-Orlitz¹,

Gerlicz-Kowalczuk²,

Dziankowska‐Bartkowiak³

2012

pdia

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“…As 5α-reductase represents the rate-limiting step enzyme in the synthesis of the GABAergic steroid allopregnanolone, it is assumed that downregulation of 5α-reductase mediates aggressive behavior, anxiety and cognitive dysfunction observed in socially isolated mice. Inhibition of 5α-reductase by finasteride, a compound used for the treatment of benign prostatic hyperplasia and androgenetic alopecia, induced depression-like states in a prospective study of 128 men [24]. Furthermore, mice treated with finasteride display depression-like behavior in the forced swim test [25].…”

Section: Discussionmentioning

confidence: 99%

Cortisol Metabolism in Depressed Patients and Healthy Controls

et al. 2009

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Background: Chronic stress as well as major depressive disorders are associated with hypercortisolemia and impaired hypothalamic-pituitary-adrenocortical axis functioning. The aim of this study was to determine whether in major depression changes in the activity patterns of local modulators of glucocorticoid action might contribute to an increase in cortisol bioavailability and if they change during antidepressant treatment and clinical response. Methods: Concentrations of urinary total cortisol (UFF), urinary total cortisone (UFE), tetrahydrocortisone (THE), tetrahydrocortisol (THF) and allo-THF (5α-THF) were measured in 10-hour nocturnal urine samples of 19 depressed patients and 15 healthy controls. The activity of 11β-hydroxysteroid dehydrogenases (11β-HSD) as well as 5α- and 5β-reductases was assessed by calculating the ratios of glucocorticoid metabolites. Patients were treated for 28 days with either mirtazapine or venlafaxine. Enzyme activity was observed during the course of treatment and compared to healthy controls. Responders to treatment were selected for this analysis. Results: Depressed patients showed reduced 5α-reductase activity manifested as a significantly lower amount of 5α-THF (102.8 ± 167.2 vs. 194.6 ± 165.8 μg, p = 0.019). The increase in the UFF/UFE ratio (0.73 ± 0.32 vs. 0.29 ± 0.13, p < 0.0001) indicates reduced activity of renal 11β-hydroxysteroid dehydrogenase type 2 (11β-HSD2). During pharmacological treatment, 5α-reductase activity in patients returned to the level of the control group, while the decrease in 11β-HSD2 activity persisted until day 28. Conclusions: Our results show changes in activity of intracellular modulators of steroid action in major depressive disorders, particularly a reduced activity of the intracellular cortisol-deactivating enzymes 5α-reductase and 11β-HSD2. These changes suggest an increase in cortisol bioavailability within tissues.

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“…Several research studies have investigated the adverse psychological effects of finasteride (Altomare & Capella, 2002;Ganzer, Jacobs, & Iqbal, 2014;Irwig, 2012;Melcangi et al, 2013;Rahimi-Ardabili, Pourandarjani, Habibollahi, & Mualeki, 2006;Traish, Hassani, Guay, Zitzmann, & Hansen, 2011). In 2002, researchers investigating depression as an adverse effect of finasteride, researchers reported that men (n = 17) who had taken 1 mg per day of finasteride for AGA developed moderate to severe depression during treatment and stated that further studies were needed (Altomare & Capella, 2002).…”

Section: Introductionmentioning

confidence: 99%

Emotional Consequences of Finasteride: Fool’s Gold

Ganzer

Jacobs

2016

Am J Mens Health

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Androgenetic alopecia, the gradual, progressive loss of hair frequently results in psychological despair, in part related to changes in self-image. Current androgenetic alopecia treatments are limited to hair transplantation and medications that inhibit dihydrotestosterone, a potent androgen associated with follicular micronization. Users of finasteride, which prevents dihydrotestosterone production, report serious physical and emotional adverse effects, collectively known as post-finasteride syndrome. Psychiatric illnesses and personality traits, specifically neuroticism influence emotional well-being. Limited research exists exploring the psychological corollaries of post-finasteride syndrome and preexisting Axis I and Axis II mental health conditions. The aim of this study was to explore how having a preexisting personal and/or familial history of a psychiatric diagnosis and certain personality traits may influence anxiety and depression among finasteride users. Participants in this online survey completed the Beck Depression Inventory, the Beck Anxiety Inventory, and Ten-Item Personality Inventory. An important finding in this study was that almost 57% ( n = 97) of men reported a psychiatric diagnosis and 28% ( n = 27) had a first-degree relative with a mental health disorder, of this group 17 only had a family history. Nearly 50% of the men surveyed reported clinically significant depression as evidenced by Beck Depression Inventory score and 34% experienced anxiety on the Beck Anxiety Inventory. There were no statistically significant trends in personality traits reported. Results provide evidence on the need to screen for psychiatric history and counseling patients about the potential psychological consequences of finasteride. Prescribing clinicians should carefully weigh the risk/benefit ratio with these patients.

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Finasteride induced depression: a prospective study

Cited by 105 publications

References 43 publications

Self-reported depression and sense of disease in cosmetic patients

Self-reported depression and sense of disease in cosmetic patients

Cortisol Metabolism in Depressed Patients and Healthy Controls

Emotional Consequences of Finasteride: Fool’s Gold

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